Authorship and Text-making in Early China

Der vorliegende Band berichtet über die bisherigen Aktivitäten des Instituts, seine Historie und Perspektiven und erlaubt darüber hinaus auch einen Blick hinter die Kulissen des Aufbaus eines Instituts in Afrika und auf die Lebensumstände und Eindrücke der Mitarbeiter

Authorship and Text-making in Early China

Der vorliegende Band berichtet über die bisherigen Aktivitäten des Instituts, seine Historie und Perspektiven und erlaubt darüber hinaus auch einen Blick hinter die Kulissen des Aufbaus eines Instituts in Afrika und auf die Lebensumstände und Eindrücke der Mitarbeiter

Thinking transformation:architectural design process of Nest

Abstract. This diploma thesis Thinking Transformation — Architectural Design Process of Nest aims to look at how abstract or immaterial ideas could be developed to concrete architectural results by revealing the whole design process. The analysis of the design process will also disclose one way of designing. My thesis consists of two parts: the actual design work and its process and the visualization and analysis of the design process. The design goal is to point out important issues of resting through enlightening of the personal experiences and references of the good resting place design for the public. The visualization and analysis part is focusing on revealing the design process and its level of complexity regardless of the fairly small size of the architectural project. The methodological approach in my diploma thesis has its origin in the idea of reflective practitioner and research-by-design. My thesis also aims to be one of the references of reflective study which makes readers reflect on their design process

Seeing is believing, but is it monitoring?

Prior studies conceptualize institutional monitoring by the terms “concentration of institutional investors” and “heterogeneity in institutional investors”. This paper focuses on the frequency of institutional investors’ corporate site visits (CSV) in relation to firms’ performance. In the context of acquisition, I hypothesize that bidding firms with more institutional investors’ CSV will have higher abnormal announcement-period return. However, the results indicate that more institutional investors’ CSV cannot predict better acquisition decisions, unless they meet firms’ CEO or high-level managements during site visits. The reason could be that internal communication in companies is not efficient due to the hierarchy of the organization. These findings survive a number of robustness tests, including tests after winsorizing data, alternative measures for corporate site visit, and alternative samples. Moreover, further analysis shows that institutional investor’ CSV and institutional ownership are complements of each other in terms of enhancing corporate governance

Synthetic Studies of Meloscine and Related Alkaloids

The first section of this dissertation describes the discovery and studies of new radical desulfonylation reactions. These reactions allow convenient access to structurally diverse imines under mild conditions. We have examined several related desulfonylation reactions, and the results of this investigation support the general mechanism that we initially proposed. The second section details the synthesis of (±)-epimeloscine, (±)-meloscine, and analogs. The invention of a novel, cascade radical annulation of divinylcyclopropanes enables expedient synthesis of (±)-epimeloscine and (±)-meloscine, and analogs. Preliminary studies on a chirality transfer approach towards (+)-meloscine are discussed. This approach delivered only moderate chirality transfer, however, a new cascade cope/ene reaction was discovered along the way

Preparation of Macrocyclic

The first examples of catalyst-controlled stereoselective macrocyclic ring-closing metathesis reactions that generate Z-enoates as well as (E,Z)- or (Z,E)-dienoates are disclosed. Reactions promoted by 3.0–10 mol % of a Mo-based monoaryloxide pyrrolide complex proceed to completion within 2–6 h at room temperature. The desired macrocycles are formed in 79:21 to >98:2 Z/E selectivity; stereoisomerically pure products can be obtained in 43–75% yield after chromatography. Utility is demonstrated by application to a concise formal synthesis of the natural product (+)-aspicilin.United States. National Institutes of Health (GM-59426

Direct synthesis of Z-alkenyl halides through catalytic cross-metathesis

Olefin metathesis has had a large impact on modern organic chemistry, but important shortcomings remain: for example, the lack of efficient processes that can be used to generate acyclic alkenyl halides. Halo-substituted ruthenium carbene complexes decompose rapidly or deliver low activity and/or minimal stereoselectivity, and our understanding of the corresponding high-oxidation-state systems is limited. Here we show that previously unknown halo-substituted molybdenum alkylidene species are exceptionally reactive and are able to participate in high-yielding olefin metathesis reactions that afford acyclic 1,2-disubstituted Z-alkenyl halides. Transformations are promoted by small amounts of a catalyst that is generated in situ and used with unpurified, commercially available and easy-to-handle liquid 1,2-dihaloethene reagents, and proceed to high conversion at ambient temperature within four hours. We obtain many alkenyl chlorides, bromides and fluorides in up to 91 per cent yield and complete Z selectivity. This method can be used to synthesize biologically active compounds readily and to perform site- and stereoselective fluorination of complex organic molecules.National Institute of General Medical Sciences (U.S.) (GM-59426 and GM-57212

Towards Better Dermoscopic Image Feature Representation Learning for Melanoma Classification

Deep learning-based melanoma classification with dermoscopic images has recently shown great potential in automatic early-stage melanoma diagnosis. However, limited by the significant data imbalance and obvious extraneous artifacts, i.e., the hair and ruler markings, discriminative feature extraction from dermoscopic images is very challenging. In this study, we seek to resolve these problems respectively towards better representation learning for lesion features. Specifically, a GAN-based data augmentation (GDA) strategy is adapted to generate synthetic melanoma-positive images, in conjunction with the proposed implicit hair denoising (IHD) strategy. Wherein the hair-related representations are implicitly disentangled via an auxiliary classifier network and reversely sent to the melanoma-feature extraction backbone for better melanoma-specific representation learning. Furthermore, to train the IHD module, the hair noises are additionally labeled on the ISIC2020 dataset, making it the first large-scale dermoscopic dataset with annotation of hair-like artifacts. Extensive experiments demonstrate the superiority of the proposed framework as well as the effectiveness of each component. The improved dataset publicly avaliable at https://github.com/kirtsy/DermoscopicDataset.Comment: ICONIP 2021 conferenc