81 research outputs found
Towards single-molecule nanomechanical mass spectrometry
Mass spectrometry provides rapid and quantitative identification of protein species with relatively low sample consumption. The trend towards biological analysis at increasingly smaller scales, ultimately down to the volume of an individual cell, continues, and mass spectrometry with a sensitivity of a few to single molecules will be necessary. Nanoelectromechanical systems provide unparalleled mass sensitivity, which is now sufficient for the detection of individual molecular species in real time. Here, we report the first demonstration of mass spectrometry based on single biological molecule detection with a nanoelectromechanical system. In our nanoelectromechanical–mass spectrometry system, nanoparticles and protein species are introduced by electrospray injection from the fluid phase in ambient conditions into vacuum, and are subsequently delivered to the nanoelectromechanical system detector by hexapole ion optics. Precipitous frequency shifts, proportional to the mass, are recorded in real time as analytes adsorb, one by one, onto a phase-locked, ultrahigh-frequency nanoelectromechanical resonator. These first nanoelectromechanical system–mass spectrometry spectra, obtained with modest mass sensitivity from only several hundred mass adsorption events, presage the future capabilities of this approach. We also outline the substantial improvements that are feasible in the near term, some of which are unique to nanoelectromechanical system based-mass spectrometry
Quantum driven Bounce of the future Universe
It is demonstrated that due to back-reaction of quantum effects, expansion of
the universe stops at its maximum and takes a turnaround. Later on, it
contracts to a very small size in finite future time. This phenomenon is
followed by a " bounce" with re-birth of an exponentially expanding
non-singular universe
Curvature Inspired Cosmological Scenario
Using modified gravity with non-linear terms of curvature, and (with being the positive real number and being the scalar
curvature), cosmological scenario,beginning at the Planck scale, is obtained.
Here, a unified picture of cosmology is obtained from gravity. In this
scenario, universe begins with power-law inflation, followed by deceleration
and acceleration in the late universe as well as possible collapse of the
universe in future. It is different from dark energy models with
non-linear curvature terms assumed as dark energy. Here, dark energy terms are
induced by linear as well as non-linear terms of curvature in Friedmann
equation being derived from modified gravity.It is also interesting to see
that, in this model, dark radiation and dark matter terms emerge spontaneously
from the gravitational sector. It is found that dark energy, obtained here,
behaves as quintessence in the early universe and phantom in the late universe.
Moreover, analogous to brane-tension in brane-gravity inspired Friedmann
equation, a tension term arises here being called as cosmic tension.
It is found that, in the late universe, Friedmann equation (obtained here)
contains a term ( being the phantom energy density)
analogous to a similar term in Friedmann equation with loop quantum effects, if
and brane-gravity correction when Comment: 19 Pages. To appear in Int. J. Thro. Phy
Single-protein nanomechanical mass spectrometry in real time
Nanoelectromechanical systems (NEMS) resonators can detect mass with exceptional sensitivity. Previously, mass spectra from several hundred adsorption events were assembled in NEMS-based mass spectrometry using statistical analysis. Here, we report the first realization of single-molecule NEMS-based mass spectrometry in real time. As each molecule in the sample adsorbs on the resonator, its mass and position of adsorption are determined by continuously tracking two driven vibrational modes of the device. We demonstrate the potential of multimode NEMS-based mass spectrometry by analysing IgM antibody complexes in real time. NEMS-based mass spectrometry is a unique and promising new form of mass spectrometry: it can resolve neutral species, provide a resolving power that increases markedly for very large masses, and allow the acquisition of spectra, molecule-by-molecule, in real time
Quantum nondemolition measurement of mechanical motion quanta
The fields of opto- and electromechanics have facilitated numerous advances
in the areas of precision measurement and sensing, ultimately driving the
studies of mechanical systems into the quantum regime. To date, however, the
quantization of the mechanical motion and the associated quantum jumps between
phonon states remains elusive. For optomechanical systems, the coupling to the
environment was shown to preclude the detection of the mechanical mode
occupation, unless strong single photon optomechanical coupling is achieved.
Here, we propose and analyse an electromechanical setup, which allows to
overcome this limitation and resolve the energy levels of a mechanical
oscillator. We find that the heating of the membrane, caused by the interaction
with the environment and unwanted couplings, can be suppressed for carefully
designed electromechanical systems. The results suggest that phonon number
measurement is within reach for modern electromechanical setups.Comment: 8 pages, 5 figures plus 24 pages, 11 figures supplemental materia
Universal Vectorial and Ultrasensitive Nanomechanical Force Field Sensor
Miniaturization of force probes into nanomechanical oscillators enables
ultrasensitive investigations of forces on dimensions smaller than their
characteristic length scale. Meanwhile it also unravels the force field
vectorial character and how its topology impacts the measurement. Here we
expose an ultrasensitive method to image 2D vectorial force fields by
optomechanically following the bidimensional Brownian motion of a singly
clamped nanowire. This novel approach relies on angular and spectral tomography
of its quasi frequency-degenerated transverse mechanical polarizations:
immersing the nanoresonator in a vectorial force field does not only shift its
eigenfrequencies but also rotate eigenmodes orientation as a nano-compass. This
universal method is employed to map a tunable electrostatic force field whose
spatial gradients can even take precedence over the intrinsic nanowire
properties. Enabling vectorial force fields imaging with demonstrated
sensitivities of attonewton variations over the nanoprobe Brownian trajectory
will have strong impact on scientific exploration at the nanoscale
Remediation of salt-affected soil by the addition of organic matter: an investigation into improving glutinous rice productivity
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