Market overreaction and investment strategies

We investigated the overreaction of the Korean market in response to shocks in the US stock market, and analysed the dynamic relationship between these two markets since 1996. We found that the KOSPI 200 index futures overreacted to the S&P 500 index returns during the period from 2000 to 2009 when the Korean market was in its growth stage. As the Korean market matured and the KOSPI 200 overnight futures were introduced in 2009, the overreaction disappeared. When investors employed the Kelly model or Value-at-Risk to exploit the overreaction, their trading strategies produced significant profits during the growth stage even after considering transaction costs and risk, but the profits attenuated once the overnight futures market was launched in 2009

Efficient isolation and elution of cellular proteins using aptamer-mediated protein precipitation assay

Protein precipitation is one of the most widely used methods for antigen detection and purification in biological research. We developed a reproducible aptamer-mediated magnetic protein precipitation method that is able to efficiently capture, purify and isolate the target proteins. We discovered DNA aptamers having individually high affinity and specificity against human epidermal growth factor receptor (EGFR) and human insulin receptor (INSR). Using aptamers and magnetic beads, we showed it is highly efficient technique to enrich endogenous proteins complex and is applicable to identify physiologically relevant protein-protein interactions with minimized nonspecific binding of proteins. The results presented here indicate that aptamers would be applicable as a useful and cost-effective tool to identify the presence of the particular target protein with their specific protein partners. (C) 2014 Elsevier Inc. All rights reserved.X1156Ysciescopu

Size-resolved source apportionment of ambient particles by positive matrix factorization at Gosan background site in East Asia

International audienceSize- and time-resolved aerosol samples were collected using an eight-stage Davis rotating unit for monitoring (DRUM) sampler from 29 March to 29 May in 2002 at Gosan, Jeju Island, Korea, which is one of the representative background sites in East Asia. These samples were analyzed using synchrotron X-ray fluorescence for 3-h average concentrations of 19 elements consisting of S, Si, Al, Fe, Ca, Cl, Cu, Zn, Ti, K, Mn, Pb, Ni, V, Se, As, Rb, Cr, Br. The size-resolved data sets were then analyzed using the positive matrix factorization (PMF) technique in order to identify possible sources and estimate their contribution to particulate matter mass. PMF analysis uses the uncertainty of the measured data to provide an optimal weighting. Fifteen sources were resolved in eight size ranges (0.07~12 ?m) and included continental soil, local soil, sea salt, biomass/biofuel burning, coal combustion, oil heating furnace, residual oil fired boiler, municipal incineration, nonferrous metal source, ferrous metal source, gasoline vehicle, diesel vehicle, copper smelter and volcanic emission. PMF analysis of size-resolved source contributions showed that natural sources represented by local soil, sea salt and continental soil contributed about 79% to the predicted primary particulate matter (PM) mass in the coarse size range (1.15~12 ?m). On the other hand, anthropogenic sources such as coal combustion and biomass/biofuel burning contributed about 60% in the fine size range (0.56~2.5 ?m). The diesel vehicle source contributed the most in the ultra-fine size range (0.07~0.56 ?m) and was responsible for about 52% of the primary PM mass

Size-resolved source apportionment of ambient particles by positive matrix factorization

International audienceSize- and time-resolved aerosol samples were collected using an eight-stage DRUM sampler from 29 March to 29 May in 2002 at Gosan, Jeju Island, Korea, which is one of the representative background sites in East Asia. These samples were analyzed using synchrotron X-ray fluorescence for 3-h average concentrations of 19 elements consisting of S, Si, Al, Fe, Ca, Cl, Cu, Zn, Ti, K, Mn, Pb, Ni, V, Se, As, Rb, Cr, Br. The size-resolved data sets were then analyzed using the positive matrix factorization (PMF) technique in order to identify possible sources and estimate their contribution to particulate matter mass. PMF analysis uses the uncertainty of the measured data to provide an optimal weighting. Fifteen sources were resolved in eight size ranges (0.07?12 µm) and included Chinese aerosol, soil dust, sea salt, biomass burning, coal combustion, oil heating furnace, residual oil-fired boiler, municipal incineration, nonferrous metal source, ferrous metal source, gasoline vehicle, diesel vehicle, copper smelter, and volcano emission. PMF analysis of size-resolved source contributions showed that natural sources represented by soil dust, sea salt and Chinese aerosol contributed about 79% to the predicted primary PM mass in the coarse size range (1.15?12 µm). On the other hand, anthropogenic sources such as coal combustion and biomass burning contributed about 60% in the fine size range (0.56?2.5 µm). The diesel vehicle source contributed the most in the ultra-fine size range (0.07?0.56 µm) and was responsible for about 52% of the primary PM mass

Culture, heritage looting, and tourism: A text mining review approach

ourism scholars have been devoted to exploring the significance of cultural heritage in generating economic, environmental, and social values. However, limited efforts were found to verify potential threats that demolish these values such as looting issue in the global heritage tourism industry. Therefore, this study has reviewed extant publications to demonstrate the potential emerged textual clusters discussed by previous studies. It also summarized the network distribution of articles journals and authors’ affiliations to capture the mobility and diversity with a focus on the business and tourism management field. Hence, the core clusters discovered were related to heritage destruction, public access, world heritage, human rights, cultural heritage preservation, and protection of cultural heritage in the event. The results have established theoretical insights and research agendas for future tourism studies, while it determined critical drawbacks in employing technology tools including virtual reality, augmented reality, and artificial intelligence for cultural heritage preservation/protection.info:eu-repo/semantics/publishedVersio

Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation

Due to their high affinity and specificity, aptamers have been widely used as effective inhibitors in clinical applications. However, the ability to activate protein function through aptamer-protein interaction has not been well-elucidated. To investigate their potential as target-specific agonists, we used SELEX to generate aptamers to the insulin receptor (IR) and identified an agonistic aptamer named IR-A48 that specifically binds to IR, but not to IGF-1 receptor. Despite its capacity to stimulate IR autophosphorylation, similar to insulin, we found that IR-A48 not only binds to an allosteric site distinct from the insulin binding site, but also preferentially induces Y1150 phosphorylation in the IR kinase domain. Moreover, Y1150-biased phosphorylation induced by IR-A48 selectively activates specific signaling pathways downstream of IR. In contrast to insulin-mediated activation of IR, IR-A48 binding has little effect on the MAPK pathway and proliferation of cancer cells. Instead, AKT S473 phosphorylation is highly stimulated by IR-A48, resulting in increased glucose uptake both in vitro and in vivo. Here, we present IR-A48 as a biased agonist able to selectively induce the metabolic activity of IR through allosteric binding. Furthermore, our study also suggests that aptamers can be a promising tool for developing artificial biased agonists to targeted receptors.111615Ysciescopu

KMT-2016-BLG-2052L: Microlensing Binary Composed of M Dwarfs Revealed from a Very Long Time-scale Event

We present the analysis of a binary microlensing event KMT-2016-BLG-2052, for which the lensing-induced brightening of the source star lasted for 2 seasons. We determine the lens mass from the combined measurements of the microlens parallax \pie and angular Einstein radius \thetae. The measured mass indicates that the lens is a binary composed of M dwarfs with masses of $M_1\sim 0.34~M_\odot$ and $M_2\sim 0.17~M_\odot$. The measured relative lens-source proper motion of $\mu\sim 3.9~{\rm mas}~{\rm yr}^{-1}$ is smaller than $\sim 5~{\rm mas}~{\rm yr}^{-1}$ of typical Galactic lensing events, while the estimated angular Einstein radius of \thetae\sim 1.2~{\rm mas} is substantially greater than the typical value of $\sim 0.5~{\rm mas}$. Therefore, it turns out that the long time scale of the event is caused by the combination of the slow $\mu$ and large \thetae rather than the heavy mass of the lens. From the simulation of Galactic lensing events with very long time scales ($t_{\rm E}\gtrsim 100$ days), we find that the probabilities that long time-scale events are produced by lenses with masses $\geq 1.0~M_\odot$ and $\geq 3.0~M_\odot$ are $\sim 19\%$ and 2.6\%, respectively, indicating that events produced by heavy lenses comprise a minor fraction of long time-scale events. The results indicate that it is essential to determine lens masses by measuring both \pie and \thetae in order to firmly identify heavy stellar remnants such as neutron stars and black holes.Comment: 9 pages, 11 figure

Ultrahigh Energy Nuclei in the Galactic Magnetic Field

Observations are consistent with a significant fraction of heavy nuclei in the cosmic ray flux above a few times 10^19 eV. Such nuclei can be deflected considerably in the Galactic magnetic field, with important implications for the search of their sources. We perform detailed simulations of heavy nuclei propagation within recent Galactic magnetic field models. While such models are not yet sufficiently constrained to predict deflection maps in detail, we find general features of the distribution of (de-) magnified flux from sources. Since in most theoretical models sources of heavy nuclei are located in the local large scale structure of galaxies, we show examples of images of several nearby galaxy clusters and of the supergalactic plane. Such general features may be useful to develop efficient methods for source reconstruction from observed ultrahigh energy cosmic ray arrival directions.Comment: 17 pages, 11 figures. Published in JCA