902 research outputs found
A Nonparametric Method for the Derivation of α/β Ratios from the Effect of Fractionated Irradiations
Multifractionation isoeffect data are commonly analysed under the assumption that cell survival determines the observed tissue or tumour response, and that it follows a linear-quadratic dose dependence. The analysis is employed to derive the α/β ratios of the linear-quadratic dose dependence, and different methods have been developed for this purpose. A common method uses the so-called Fe plot. A more complex but also more rigorous method has been introduced by Lam et al. (1979). Their method, which is based on numerical optimization procedures, is generalized and somewhat simplified in the present study. Tumour-regrowth data are used to explain the nonparametric procedure which provides α/β ratios without the need to postulate analytical expressions for the relationship between cell survival and regrowth delay
Pair production of neutralinos via gluon-gluon collisions
The production of a neutralino pair via gluon-gluon fusion is studied in the
minimal supersymmetric model(MSSM) at proton-proton colliders. The numerical
analysis of their production rates are carried out in the mSUGRA scenario. The
results show that this cross section may reach about 80 femto barn for
pair production and 23 femto barn
for pair production with suitable
input parameters at the future LHC collider. It shows that this loop mediated
process can be competitive with the quark-antiquark annihilation process at the
LHC.Comment: LaTex file, l4 pages, 5 EPS figure
Pair Production of the Lightest Chargino via Gluon-Gluon Collisions
The production of the lightest chargino pair from gluon-gluon fusion is
studied in the minimal supersymmetric model(MSSM) at proton-proton colliders.
We find that with the chosen parameters, the production rate of the subprocess
can be over 2.7 femto barn when the chargino is higgsino-like, and the
corresponding total cross section in proton-proton collider can reach 56 femto
barn at the LHC in the CP-conserving MSSM. It shows that this loop mediated
subprocess can be competitive with the standard Drell-Yan subprocess in
proton-proton colliders, especially at the LHC. Furthermore, our calculation
shows it would be possible to extract information about some CP-violating phase
parameters, if we collected enough chargino pair events.Comment: 39 pages, LaTex, 8 figure
Family Unification on an Orbifold
We construct a family-unified model on a Z_2xZ_2 orbifold in five dimensions.
The model is based on a supersymmetric SU(7) gauge theory. The gauge group is
broken by orbifold boundary conditions to a product of grand unified SU(5) and
SU(2)xU(1) flavor symmetry. The structure of Yukawa matrices is generated by an
interplay between spontaneous breaking of flavor symmetry and geometric factors
arising due to field localization in the extra dimension.Comment: 13 page
Localized anomalies in orbifold gauge theories
We apply the path-integral formalism to compute the anomalies in general
orbifold gauge theories (including possible non-trivial Scherk-Schwarz boundary
conditions) where a gauge group G is broken down to subgroups H_f at the fixed
points y=y_f. Bulk and localized anomalies, proportional to \delta(y-y_f), do
generically appear from matter propagating in the bulk. The anomaly zero-mode
that survives in the four-dimensional effective theory should be canceled by
localized fermions (except possibly for mixed U(1) anomalies). We examine in
detail the possibility of canceling localized anomalies by the Green-Schwarz
mechanism involving two- and four-forms in the bulk. The four-form can only
cancel anomalies which do not survive in the 4D effective theory: they are
called globally vanishing anomalies. The two-form may cancel a specific class
of mixed U(1) anomalies. Only if these anomalies are present in the 4D theory
this mechanism spontaneously breaks the U(1) symmetry. The examples of five and
six-dimensional Z_N orbifolds are considered in great detail. In five
dimensions the Green-Schwarz four-form has no physical degrees of freedom and
is equivalent to canceling anomalies by a Chern-Simons term. In all other
cases, the Green-Schwarz forms have some physical degrees of freedom and leave
some non-renormalizable interactions in the low energy effective theory. In
general, localized anomaly cancellation imposes strong constraints on model
building.Comment: 30 pages, 4 figures. v2: reference adde
Upper montane grassland structure within six subranges of Serra do Mar, Southern Brazil
Small-molecule dual PLK1 and BRD4 inhibitors are active against preclinical models of pediatric solid tumors
Simultaneous inhibition of multiple molecular targets is an established strategy to improve the continuance of clinical response to therapy. Here, we screened 49 molecules with dual nanomolar inhibitory activity against BRD4 and PLK1, best classified as dual kinase-bromodomain inhibitors, in pediatric tumor cell lines for their antitumor activity. We identified two candidate dual kinase-bromodomain inhibitors with strong and tumor-specific activity against neuroblastoma, medulloblastoma, and rhabdomyosarcoma tumor cells. Dual PLK1 and BRD4 inhibitor treatment suppressed proliferation and induced apoptosis in pediatric tumor cell lines at low nanomolar concentrations. This was associated with reduced MYCN-driven gene expression as assessed by RNA sequencing. Treatment of patient-derived xenografts with dual inhibitor UMB103 led to significant tumor regression. We demonstrate that concurrent inhibition of two central regulators of MYC protein family of protooncogenes, BRD4, and PLK1, with single small molecules has strong and specific antitumor effects in preclinical pediatric cancer models
Measurement of the p-pbar -> Wgamma + X cross section at sqrt(s) = 1.96 TeV and WWgamma anomalous coupling limits
The WWgamma triple gauge boson coupling parameters are studied using p-pbar
-> l nu gamma + X (l = e,mu) events at sqrt(s) = 1.96 TeV. The data were
collected with the DO detector from an integrated luminosity of 162 pb^{-1}
delivered by the Fermilab Tevatron Collider. The cross section times branching
fraction for p-pbar -> W(gamma) + X -> l nu gamma + X with E_T^{gamma} > 8 GeV
and Delta R_{l gamma} > 0.7 is 14.8 +/- 1.6 (stat) +/- 1.0 (syst) +/- 1.0 (lum)
pb. The one-dimensional 95% confidence level limits on anomalous couplings are
-0.88 < Delta kappa_{gamma} < 0.96 and -0.20 < lambda_{gamma} < 0.20.Comment: Submitted to Phys. Rev. D Rapid Communication
Measurement of the ttbar Production Cross Section in ppbar Collisions at sqrt{s} = 1.96 TeV using Kinematic Characteristics of Lepton + Jets Events
We present a measurement of the top quark pair ttbar production cross section
in ppbar collisions at a center-of-mass energy of 1.96 TeV using 230 pb**{-1}
of data collected by the DO detector at the Fermilab Tevatron Collider. We
select events with one charged lepton (electron or muon), large missing
transverse energy, and at least four jets, and extract the ttbar content of the
sample based on the kinematic characteristics of the events. For a top quark
mass of 175 GeV, we measure sigma(ttbar) = 6.7 {+1.4-1.3} (stat) {+1.6- 1.1}
(syst) +/-0.4 (lumi) pb, in good agreement with the standard model prediction.Comment: submitted to Phys.Rev.Let
Measurement of the ttbar Production Cross Section in ppbar Collisions at sqrt(s)=1.96 TeV using Lepton + Jets Events with Lifetime b-tagging
We present a measurement of the top quark pair () production cross
section () in collisions at TeV
using 230 pb of data collected by the D0 experiment at the Fermilab
Tevatron Collider. We select events with one charged lepton (electron or muon),
missing transverse energy, and jets in the final state. We employ
lifetime-based b-jet identification techniques to further enhance the
purity of the selected sample. For a top quark mass of 175 GeV, we
measure pb, in
agreement with the standard model expectation.Comment: 7 pages, 2 figures, 3 tables Submitted to Phys.Rev.Let
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