The risk of cancer in primary care patients with hypercalcaemia: a cohort study using electronic records.

PublishedJournal ArticleBACKGROUND: The risk of cancer with hypercalcaemia in primary care is unknown. METHODS: This was a cohort study using calcium results in patients aged ⩾40 years in a primary care electronic data set. Diagnoses of cancer in the following year were identified. RESULTS: Participants (54 267) had calcium results: 1674 (3%) were ⩾2.6 mmol l(-1). Hypercalcaemia was strongly associated with cancer, especially in males: OR 2.92, 95% CI 2.17-3.93, P=<0.001; positive predictive value (PPV) 11.5%; females: OR 1.86, 95% CI 1.39-2.50, P<0.001: PPV 4.1%. CONCLUSIONS: Hypercalcaemia is strongly associated with cancer in primary care, with men at most risk, despite hypercalcaemia being more common in women

Optimal Estimation of Several Linear Parameters in the Presence of Lorentzian Thermal Noise

In a previous article we developed an approach to the optimal (minimum variance, unbiased) statistical estimation technique for the equilibrium displacement of a damped, harmonic oscillator in the presence of thermal noise. Here, we expand that work to include the optimal estimation of several linear parameters from a continuous time series. We show that working in the basis of the thermal driving force both simplifies the calculations and provides additional insight to why various approximate (not optimal) estimation techniques perform as they do. To illustrate this point, we compare the variance in the optimal estimator that we derive for thermal noise with those of two approximate methods which, like the optimal estimator, suppress the contribution to the variance that would come from the irrelevant, resonant motion of the oscillator. We discuss how these methods fare when the dominant noise process is either white displacement noise or noise with power spectral density that is inversely proportional to the frequency ($1/f$ noise). We also construct, in the basis of the driving force, an estimator that performs well for a mixture of white noise and thermal noise. To find the optimal multi-parameter estimators for thermal noise, we derive and illustrate a generalization of traditional matrix methods for parameter estimation that can accommodate continuous data. We discuss how this approach may help refine the design of experiments as they allow an exact, quantitative comparison of the precision of estimated parameters under various data acquisition and data analysis strategies.Comment: 16 pages, 10 figures. Accepted for publication in Classical and Quantum Gravit

Noise data for a twin-engine commercial jet aircraft flying conventional, steep, and two-segment approaches

Center-line noise measurements of a twin-engine commercial jet aircraft were made during steep landing approach profiles, and during two-segment approach profiles for comparison with similar measurements made during conventional approaches. The steep and two-segment approaches showed significant noise reductions when compared with the -3 deg base line. The measured noise data were also used to develop a method for estimating the noise under the test aircraft at thrust and altitude conditions typical of current landing procedures and of landing procedures under development for the Advanced Air Traffic Control System

Local light-ray rotation

We present a sheet structure that rotates the local ray direction through an arbitrary angle around the sheet normal. The sheet structure consists of two parallel Dove-prism sheets, each of which flips one component of the local direction of transmitted light rays. Together, the two sheets rotate transmitted light rays around the sheet normal. We show that the direction under which a point light source is seen is given by a Mobius transform. We illustrate some of the properties with movies calculated by ray-tracing software.Comment: 9 pages, 6 figure

Earth - venus trajectories, 1968-69, volume 4, part b

Earth-venus trajectories 1968-196

Search for L5 Earth Trojans with DECam

Most of the major planets in the Solar system support populations of co-orbiting bodies, known as Trojans, at their L4 and L5 Lagrange points. In contrast, Earth has only one known co-orbiting companion. This paper presents the results from a search for Earth Trojans (ETs) using the DECam instrument on the Blanco Telescope at CTIO. This search found no additional Trojans in spite of greater coverage compared to previous surveys of the L5 point. Therefore, the main result of this work is to place the most stringent constraints to date on the population of ETs. These constraints depend on assumptions regarding the underlying population properties, especially the slope of the magnitude distribution (which in turn depends on the size and albedo distributions of the objects). For standard assumptions, we calculate upper limits to a 90 per cent confidence limit on the L5 population of N_(ET) < 1 for magnitude H < 15.5, N_(ET) = 60–85 for H < 19.7, and N_(ET) = 97 for H = 20.4. This latter magnitude limit corresponds to Trojans ∼300 m in size for albedo 0.15. At H = 19.7, these upper limits are consistent with previous L4 ET constraints and significantly improve L5 constraints

Trypanosomes are monophyletic: evidence from genes for glyceraldehyde phosphate dehydrogenase and small subunit ribosomal RNA.

The genomes of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major have been sequenced, but the phylogenetic relationships of these three protozoa remain uncertain. We have constructed trypanosomatid phylogenies based on genes for glycosomal glyceraldehyde phosphate dehydrogenase (gGAPDH) and small subunit ribosomal RNA (SSU rRNA). Trees based on gGAPDH nucleotide and amino acid sequences (51 taxa) robustly support monophyly of genus Trypanosoma, which is revealed to be a relatively late-evolving lineage of the family Trypanosomatidae. Other trypanosomatids, including genus Leishmania, branch paraphyletically at the base of the trypanosome clade. On the other hand, analysis of the SSU rRNA gene data produced equivocal results, as trees either robustly support or reject monophyly depending on the range of taxa included in the alignment. We conclude that the SSU rRNA gene is not a reliable marker for inferring deep level trypanosome phylogeny. The gGAPDH results support the hypothesis that trypanosomes evolved from an ancestral insect parasite, which adapted to a vertebrate/insect transmission cycle. This implies that the switch from terrestrial insect to aquatic leech vectors for fish and some amphibian trypanosomes was secondary. We conclude that the three sequenced pathogens, T. brucei, T. cruzi and L. major, are only distantly related and have distinct evolutionary histories

Gas Absorption in the KH 15D System: Further Evidence for Dust Settling in the Circumbinary Disk

Na I D lines in the spectrum of the young binary KH 15D have been analyzed in detail. We find an excess absorption component that may be attributed to foreground interstellar absorption, and to gas possibly associated with the solids in the circumbinary disk. The derived column density is log N_NaI = 12.5 cm^-2, centered on a radial velocity that is consistent with the systemic velocity. Subtracting the likely contribution of the ISM leaves log N_NaI ~ 12.3 cm^-2. There is no detectable change in the gas column density across the "knife edge" formed by the opaque grain disk, indicating that the gas and solids have very different scale heights, with the solids being highly settled. Our data support a picture of this circumbinary disk as being composed of a very thin particulate grain layer composed of millimeter-sized or larger objects that are settled within whatever remaining gas may be present. This phase of disk evolution has been hypothesized to exist as a prelude to the formation of planetesimals through gravitational fragmentation, and is expected to be short-lived if much gas were still present in such a disk. Our analysis also reveals the presence of excess Na I emission relative to the comparison spectrum at the radial velocity of the currently visible star that plausibly arises within the magnetosphere of this still-accreting young star.Comment: Accepted for publication in ApJ, 23 pages, 6 figure

Filler bar heating due to stepped tiles in the shuttle orbiter thermal protection system

An analytical study was performed to investigate the excessive heating in the tile to tile gaps of the Shuttle Orbiter Thermal Protection System due to stepped tiles. The excessive heating was evidence by visible discoloration and charring of the filler bar and strain isolation pad that is used in the attachment of tiles to the aluminum substrate. Two tile locations on the Shuttle orbiter were considered, one on the lower surface of the fuselage and one on the lower surface of the wing. The gap heating analysis involved the calculation of external and internal gas pressures and temperatures, internal mass flow rates, and the transient thermal response of the thermal protection system. The results of the analysis are presented for the fuselage and wing location for several step heights. The results of a study to determine the effectiveness of a half height ceramic fiber gap filler in preventing hot gas flow in the tile gaps are also presented

Community experiences of organised crime in Scotland

The research explored community experiences of serious organised crime in Scotland (SOC). The report provides information on the nature and extent of the impact of SOC on everyday life in the community, as well as offering suggestions for policy development. The study sought to answer the following questions: 1)What are the relationships that exist between SOC and communities in Scotland? 2)What are the experiences and perceptions of residents, stakeholders and organisations of the scope and nature of SOC within their local area? and 3)How does SOC impact on community wellbeing, and to what extent can the harms associated with SOC be mitigated