Imaging with parallel ray-rotation sheets

A ray-rotation sheet consists of miniaturized optical components that function - ray optically - as a homogeneous medium that rotates the local direction of transmitted light rays around the sheet normal by an arbitrary angle [A. C. Hamilton et al., arXiv:0809.2646 (2008)]. Here we show that two or more parallel ray-rotation sheets perform imaging between two planes. The image is unscaled and un-rotated. No other planes are imaged. When seen through parallel ray-rotation sheets, planes that are not imaged appear rotated, whereby the rotation angle changes with the ratio between the observer's and the object plane's distance from the sheets.Comment: 8 pages, 6 figure

Metarefraction

Imagine a thin sheet that performs optical illusions on the scene behind it. For example, a window that appears to reverse depth and to image objects in front of the sheet, or alternatively swimming goggles that cancel the refraction of surrounding water. This thesis will explore how such sheets may be realized. With the refinement of optical fabrication technologies, it is now possible to mass-produce miniaturized optical components. Repeating them over the surface of a sheet, their combined effect may realize optical effects from the structure, rather than the substance, of the sheet. Specifically, such components may realize arbitrary ray-direction mappings at each point on the sheet. Here such mappings, metarefractions, are explored from a range of perspectives. This thesis will explore the inception, theoretical development and ultimately the experimental realization of metarefraction. At its core, this work is primarily mathematical in nature but draws upon both experimental and computational techniques in order to test and visualize the concepts that will be discussed. Examples of such ray-direction mappings will be explored as will their ray- and wave-optical implications. This thesis is structured as follows: Initially, the definition of metarefraction, along with some existing examples, is presented. Then, ray mappings are related to negative refraction, a subject that metarefraction has a surprising number of parallels to. New forms of metarefraction are then introduced, before being incorporated into imaging systems. Later, ray-optical transformations, such as metarefraction, are shown to be limited by implicit wave-optical restrictions. In some cases, these vastly reduce the number of light fields that may be exactly transformed. After this, the most general possible metarefraction is sought, and a simple case is realized experimentally. Further restrictions are then determined, before finishing with a discussion and summary, and by considering possible directions that future work could develop in

Fermat's principle with complex refractive indices and local light-ray rotation

We describe local light-ray rotation in terms of complex refractive indices. We show that Fermat's principle holds, and we derive an extended Snell's law. The change in the angle of a light ray with respect to the normal to a refractive-index interface is described by the modulus of the refractive-index ratio, the rotation around the interface normal is described by the argument of the refractive-index ratio.Comment: 3 pages, 2 figure

Metamaterials for light rays: ray optics without wave-optical analog in the ray-optics limit

Volumes of sub-wavelength electromagnetic elements can act like homogeneous materials: metamaterials. In analogy, sheets of optical elements such as prisms can act ray-optically like homogeneous sheet materials. In this sense, such sheets can be considered to be metamaterials for light rays (METATOYs). METATOYs realize new and unusual transformations of the directions of transmitted light rays. We study here, in the ray-optics and scalar-wave limits, the wave-optical analog of such transformations, and we show that such an analog does not always exist. Perhaps, this is the reason why many of the ray-optical possibilities offered by METATOYs have never before been considered.Comment: 10 pages, 3 figures, references update

Local light-ray rotation

We present a sheet structure that rotates the local ray direction through an arbitrary angle around the sheet normal. The sheet structure consists of two parallel Dove-prism sheets, each of which flips one component of the local direction of transmitted light rays. Together, the two sheets rotate transmitted light rays around the sheet normal. We show that the direction under which a point light source is seen is given by a Mobius transform. We illustrate some of the properties with movies calculated by ray-tracing software.Comment: 9 pages, 6 figure

Community Impact of Public Processions

Research into the impact of public processions on community life in Scoltand.  The research paid particular attention to the impact of problematic processions, and how these processions could be better policed and managed

Relationship Between Venules and Perivascular Spaces in Sporadic Small Vessel Diseases

Background and Purpose— Perivascular spaces (PVS) around venules may help drain interstitial fluid from the brain. We examined relationships between suspected venules and PVS visible on brain magnetic resonance imaging. Methods— We developed a visual venular quantification method to examine the spatial relationship between venules and PVS. We recruited patients with lacunar stroke or minor nondisabling ischemic stroke and performed brain magnetic resonance imaging and retinal imaging. We quantified venules on gradient echo or susceptibility-weighted imaging and PVS on T2-weighted magnetic resonance imaging in the centrum semiovale and then determined overlap between venules and PVS. We assessed associations between venular count and patient demographic characteristics, vascular risk factors, small vessel disease features, retinal vessels, and venous sinus pulsatility. Results— Among 67 patients (69% men, 69.0±9.8 years), only 4.6% (range, 0%–18%) of venules overlapped with PVS. Total venular count increased with total centrum semiovale PVS count in 55 patients after accounting for venule-PVS overlap (β=0.468 [95% CI, 0.187–0.750]) and transverse sinus pulsatility (β=0.547 [95% CI, 0.309–0.786]) and adjusting for age, sex, and systolic blood pressure. Conclusions— Despite increases in both visible PVS and suspected venules, we found minimal spatial overlap between them in patients with sporadic small vessel disease, suggesting that most magnetic resonance imaging-visible centrum semiovale PVS are periarteriolar rather than perivenular

Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3

Background: Cerebral small vessel disease is a major cause of dementia and stroke, visible on brain magnetic resonance imaging. Recent data suggest that small vessel disease lesions may be dynamic, damage extends into normal-appearing brain and microvascular dysfunctions include abnormal blood–brain barrier leakage, vasoreactivity and pulsatility, but much remains unknown regarding underlying pathophysiology, symptoms, clinical features and risk factors of small vessel disease. Patients and Methods: The Mild Stroke Study 3 is a prospective observational cohort study to identify risk factors for and clinical implications of small vessel disease progression and regression among up to 300 adults with non-disabling stroke. We perform detailed serial clinical, cognitive, lifestyle, physiological, retinal and brain magnetic resonance imaging assessments over one year; we assess cerebrovascular reactivity, blood flow, pulsatility and blood–brain barrier leakage on magnetic resonance imaging at baseline; we follow up to four years by post and phone. The study is registered ISRCTN 12113543. Summary: Factors which influence direction and rate of change of small vessel disease lesions are poorly understood. We investigate the role of small vessel dysfunction using advanced serial neuroimaging in a deeply phenotyped cohort to increase understanding of the natural history of small vessel disease, identify those at highest risk of early disease progression or regression and uncover novel targets for small vessel disease prevention and therapy

Characterisation of proteins in excretory/secretory products collected from salmon lice, Lepeophtheirus salmonis

Background  The salmon louse, Lepeophtheirus salmonis, is an ectoparasitic copepod which feeds on the mucus, skin and blood of salmonid fish species. The parasite can persist on the surface of the fish without any effective control being exerted by the host immune system. Other ectoparasitic invertebrates produce compounds in their saliva, excretions and/or secretions which modulate the host immune responses allowing them to remain on or in the host during development. Similarly, compounds are produced in secretions of L. salmonis which are thought to be responsible for immunomodulation of the host responses as well as other aspects of crucial host-parasite interactions.  Methods  In this study we have identified and characterised the proteins in the excretory/secretory (E/S) products of L. salmonis using LC-ESI-MS/MS.  Results  In total 187 individual proteins were identified in the E/S collected from adult lice and pre-adult sea lice. Fifty-three proteins, including 13 serine-type endopeptidases, 1 peroxidase and 5 vitellogenin-like proteins were common to both adult and pre-adult E/S products. One hundred and seven proteins were identified in the adult E/S but not in the pre-adult E/S and these included serine and cysteine-type endopeptidases, vitellogenins, sphingomyelinase and calreticulin. A total of 27 proteins were identified in pre-adult E/S products but not in adult E/S.  Conclusions  The assigned functions of these E/S products and the potential roles they play in host-parasite interaction is discussed