Les compromis à court et à long terme associés à la reproduction chez les ongulés femelles : l'exemple de la chèvre de montagne

Les espèces longévives ont développé une stratégie de reproduction conservatrice où les individus produisent peu de jeunes annuellement et déploient leur effort reproducteur sur plusieurs années. Ainsi, plusieurs facteurs propres à l'individu, tout comme de nombreuses variables environnementales, peuvent grandement affecter la reproduction annuelle, entraînant des effets directs sur l'aptitude phénotypique individuelle et des effets indirects sur la dynamique des populations. En utilisant des données longitudinales sur des populations sauvages d'individus marqués, particulièrement la chèvre de montagne (Oreanmos americanus), ma thèse vise à évaluer les compromis à court et à long terme associés à la reproduction chez les ongulés femelles, tout en considérant les variations individuelles et les effets environnementaux. A court terme, mes résultats montrent que les femelles modifient leur comportement d'approvisionnement lorsqu'elles ont un jeune afin d'augmenter leur prise alimentaire et de compenser pour les coûts énergétiques de la lactation. Néanmoins, les jeunes femelles font face à un compromis important entre la croissance et la lactation. A plus long terme, les femelles qui produisent un jeune ont une plus faible probabilité de produire un jeune à nouveau, et que ce jeune survive jusqu'à 1 an, que les femelles qui ne se sont pas reproduites. Ces coûts de la reproduction sont plus élevés pour les femelles de plus faible qualité et plus jeunes que pour les femelles de plus haute qualité et plus vieilles. Les coûts s'intensifient également avec l'augmentation de la densité de population et la détérioration des conditions environnementales. A plus grande échelle, mes résultats montrent que les variations individuelles de la survie et de la reproduction influencent le rendement des populations, et que ce sont les femelles âgées qui ont le plus grand impact sur la productivité des populations. Ainsi, ma thèse permet d'illustrer les compromis réalisés par les femelles au cours de la reproduction, et ce à court et à long terme. Puisque ces compromis entraînent des coûts sur l'aptitude phénotypique et que ces coûts varient selon la qualité des individus, ces connaissances sont essentielles pour comprendre les variables sur lesquelles agissent les pressions de sélection et pour expliquer les variations dans le rendement des populations

Maternal defensive behavior of mountain goats against predation by golden eagles

Maternal defensive behavior against predators may appear risky but is common in many species. Herein we describe maternal defensive behavior of mountain goats (Oreamnos americanus) against Golden Eagle (Aquila chrysaetos) predatory attempts. We found that Golden Eagles attacked goats in 1.9% of sightings (n = 311 sightings of active Golden Eagles over 12 years) but were never successful. Mothers always defended their young against Golden Eagle attacks. Predation by Golden Eagles on young-of-the-year appears low for most ungulate species, including mountain goats. The benefits of defending offspring against eagles are likely high in ungulates, and we would therefore expect selection to favor maternal defensive behavior

Challenges and opportunities when implementing strategic foresight: lessons learned when engaging stakeholders in climate-ecological research

Ecosystems are currently experiencing rapid changes. Decision-makers need to anticipate future changes or challenges that will emerge in order to implement both short-term actions and long-term strategies for reducing undesirable impacts. Strategic foresight has been proposed to help resolve these challenges for better planning and decision-making in an uncertain future. This structured process scrutinizes the options in an uncertain future. By exploring multiple possible futures, this process can offer insights into the nature of potential changes, and thereby to better anticipate future changes and their impacts. This process is performed in close partnership with multiple actors in order to collect broader perspectives about potential futures. Through a large research initiative, we applied the strategic foresight protocol to a set of different case studies, allowing us as academic ecologists to reflect on the circumstances that may be influential for the success of this approach. Here, we present what worked and what did not, along with our perception of the underlying reasons. We highlight that the success of such an endeavour depends on the willingness of the people involved, and that building social capital among all participants involved directly from the start is essential for building the trust needed to ensure an effective functioning among social groups with different interests and values

An undecidable extension of Morley's theorem on the number of countable models

We show that Morley's theorem on the number of countable models of a countable first-order theory becomes an undecidable statement when extended to second-order logic. More generally, we calculate the number of equivalence classes of $\sigma$-projective equivalence relations in several models of set theory. Our methods include random and Cohen forcing, Woodin cardinals and Inner Model Theory.Comment: 31 page

Individual quality, early-life conditions, and reproductive success in contrasted populations of large herbivores

Variations among individuals in phenotypic quality and fitness often confound analyses of life-history strategies assessed at the population level. We used detailed long-term data from three populations of large herbivores with generation times ranging from four to nine years to quantify heterogeneity in individual quality among females, and to assess its influence on mean annual reproductive success over the lifetime (MRS). We also determined how environmental conditions in early life shaped individual quality and tested A. Lomnicki's hypothesis that variance in individual quality should increase when environmental conditions deteriorate. Using multivariate analyses (PCA), we identified one (in sheep and deer) or two (in goats) covariations among life-history traits (longevity, success in the last breeding opportunity, adult mass, and social rank) as indexes of individual quality that positively influenced MRS of females. Individual quality was reduced by unfavorable weather, low resource availability, and high population density in the year of birth. Early-life conditions accounted for 35–55% of variation in individual quality. In roe deer, we found greater variance in individual quality for cohorts born under unfavorable conditions as opposed to favorable ones, but the opposite was found in bighorn sheep and mountain goats. Our results demonstrate that heterogeneity in female quality can originate from environmental conditions in early life and can markedly influence the fitness of females in species located at different positions along the slow–fast continuum of life-history strategies

Individual quality, early-life conditions, and reproductive success in contrasted populations of large herbivores

Variations among individuals in phenotypic quality and fitness often confound analyses of life-history strategies assessed at the population level. We used detailed long-term data from three populations of large herbivores with generation times ranging from four to nine years to quantify heterogeneity in individual quality among females, and to assess its influence on mean annual reproductive success over the lifetime (MRS). We also determined how environmental conditions in early life shaped individual quality and tested A. Lomnicki's hypothesis that variance in individual quality should increase when environmental conditions deteriorate. Using multivariate analyses (PCA), we identified one (in sheep and deer) or two (in goats) covariations among life-history traits (longevity, success in the last breeding opportunity, adult mass, and social rank) as indexes of individual quality that positively influenced MRS of females. Individual quality was reduced by unfavorable weather, low resource availability, and high population density in the year of birth. Early-life conditions accounted for 35–55% of variation in individual quality. In roe deer, we found greater variance in individual quality for cohorts born under unfavorable conditions as opposed to favorable ones, but the opposite was found in bighorn sheep and mountain goats. Our results demonstrate that heterogeneity in female quality can originate from environmental conditions in early life and can markedly influence the fitness of females in species located at different positions along the slow–fast continuum of life-history strategies

Effect of scavenging on predation in a food web

The fasting endurance hypothesis (FEH) predicts strong selection for large body size in mammals living in environments where food supply is interrupted over prolonged periods of time. The Arctic is a highly seasonal and food-restricted environment, but contrary to predictions from the FEH, empirical evidence shows that Arctic mammals are often smaller than their temperate conspecifics. Intraspecific studies integrating physiology and behaviour of different-sized individuals may shed light on this paradox. We tested the FEH in free-living Svalbard reindeer Rangifer tarandus platyrhynchus. We measured daily energy expenditure (DEE), subcutaneous body temperature (Tsc) and activity levels during the late winter in 14 adult females with body masses ranging from 46.3 to 57.8 kg. Winter energy expenditure (WEE) and fasting endurance (FE) were modelled dynamically by combining these data with body composition measurements of culled individuals at the onset of winter (14 years, n = 140) and variation in activity level throughout winter (10 years, n = 70). Mean DEE was 6.3 ± 0.7 MJ/day. Lean mass, Tsc and activity had significantly positive effects on DEE. Across all 140 individuals, mean FE was 85 ± 17 days (range 48–137 days). In contrast to the predictions of the FEH, the dominant factor affecting FE was initial fat mass, while body mass and FE were not correlated. Furthermore, lean mass and fat mass were not correlated. FE was on average 80% (45 days) longer in fat than lean individuals of the same size. Reducing activity levels by ~16% or Tsc by ~5% increased FE by 7% and 4% respectively. Our results fail to support the FEH. Rather, we demonstrate that (a) the size of fat reserves can be independent of lean mass and body size within a species, (b) ecological and environmental variation influence FE via their effects on body composition and (c) physiological and behavioural adjustments can improve FE within individuals. Altogether, our results suggest that there is a selection in Svalbard reindeer to accumulate body fat, rather than to grow structurally large. </ol

Food web approach for managing Arctic wildlife populations in an era of rapid environmental change

Scientists and wildlife managers implementing adaptive monitoring and management schemes, are tasked with providing predictions of population responses to harvest and environmental changes. Such predictions are useful not only to forecast direct effects of climate, productivity, land use, or habitat degradation, but also changes in the food web, such as expanding/increasing species that are predators, prey, and competitors of populations of concern. Explicit consideration of food webs and their dynamics in more complex models could provide better predictions of future changes, and allow us to better assess the influence of management actions. Here, we present our perspective on what we have learned from conducting a number of case studies using such a food web approach with a focus on climate and harvest impacts and their implications for management. We found empirical support for many of our hypothesized food web effects, and were able in some cases to obtain short-term forecasts with slightly lower prediction error using models that account for food web dynamics compared with simpler models. Predictions are the foundation of adaptive management because they allow quantitative assessment of the effects of management actions; however, evaluating predictions requires adequate and high-quality monitoring data. Results from our case studies show that a combination of long-term monitoring and different types of study designs coupled with models of adequate complexity are likely required to better understand populations’ responses to environmental changes and harvest, as well as the consequences for food webs

Pharmacokinetic Properties of Single- and Repeated-dose Sufentanil Sublingual Tablets in Healthy Volunteers

AbstractPurposeSufentanil is a μ-opioid agonist with a high therapeutic index in preclinical studies and no active metabolites, and it is highly lipophilic, thereby enabling a transmucosal route of administration. Rapid distribution from the plasma after IV sufentanil administration results in a short duration of action requiring excessive repeated dosing if used for postoperative analgesia. The sufentanil sublingual tablet system (SSTS) is a handheld, preprogrammed, patient-controlled analgesia system designed to allow patients to self-administer sufentanil 15-μg tablets under their tongue with a 20-minute lockout. The pharmacokinetic (PK) characteristics of sufentanil, administered by different routes of delivery and after single and repeated sublingual (SL) administration, were examined in 2 studies.MethodsA randomized, open-label, crossover study in healthy subjects evaluated the PK profile of sufentanil 15 μg administered by different routes: IV, SL, buccal (BU), and PO. A second open-label, crossover study in healthy subjects evaluated the PK parameters after single and repeated doses (full SSTS drug cartridge of 40 consecutive SL doses administered every 20 minutes) of a sufentanil 15-μg SL tablet. Doses were self-administered using the SSTS.FindingsIn the route of administration study (n = 25), mean Cmax values were highest with IV administration, and bioavailability values were: SL, 59%; BU, 78%; and PO, 9%. The absorption across the oral mucosa was associated with a median plasma half-time (time from Cmax to 50% of Cmax) that was 25-fold longer (2.5 hours) with SL versus IV administration (0.1 hours). In the single- and repeated-dose study (n = 38), mean AUC0–∞ was 125.5 h · pg/mL, and Cmax was 35.0 pg/mL, with a median Tmax of 0.8 hours after the administration of a single sufentanil SL tablet. With 40 consecutive doses, Cmax was 8-fold higher compared with that of a single dose, and steady state was achieved after the 13th dose. Median plasma half-time after the 40th dose was not statistically longer than that after a single dose (2.7 vs 2.2 hours, respectively), and the median Tmax was 0.3 hours after the last repeated dose.ImplicationsThese study results support the viability of the SSTS for use in patient-controlled analgesia. The wide range of mean drug concentrations achieved after repeated dosing at 20-minute intervals compared with those with a single dose suggests the flexibility of patient-controlled dosing to meet individual analgesic requirements. The prolonged plasma half-time with SL administration is expected to provide a more appropriate duration of analgesia compared with that of IV administration, and the PK properties of repeated-dose administration support a 20-minute lockout interval

General conclusion to the special issue Moving forward on individual heterogeneity

International audienc