The position of "Variation" clause in the legal order of construction contracts With emphasis on sample contracts of Iran, FIDIC and England

ABSTRACTThe variation clause is one of the common conditions in domestic and international construction contracts. Given the executive realities of construction and industrial projects, the application of this clause seems appropriate and sometimes necessary. The subject of this clause is change in the works. Changes depending on how the clause is written, including removal, increase or decrease, replacement, change of sequence and method of construction, and any changes to what the contractor has undertaken in the initial contract. Work is also a permanent and temporary work that is required to build and complete the project and is included in the contract documents such as Service description, employer requirements and technical specifications. Variation clause is the positive condition under which the contractor undertakes to execute a unilateral change order issued by the employer without the need for another agreement. It is very important to examine the variation clause in terms of limitations due to the subject and time domain as well as the legal effects of its implementation or violation. But before that, a detailed study of the legal meaning and nature of the mentioned clause and identification of its position in the legal order of constuction contract is necessary. The present article deals with the latter

The Prevalence of Musculoskeletal Disorders and its Relation with Fatigue and Occupational Burnout in the Staff of a Petrochemical Industry

Background: Occupational burnout is a sign of various fatigue states and can cause diseases like musculoskeletal disorders. The aim of this study was to determine the prevalence of musculoskeletal disorders and its relation with fatigue and occupational burnout in the staff of a petrochemical industry. Methods: The present study is a descriptive-analytical cross-sectional study conducted on 121 personnel working in a petrochemical industry in 2017. For data collection, the Multidimensional Fatigue Inventory (MFI) questionnaire, Nordic questionnaire, and Maslach Burnout questionnaire were used. Data were analyzed using SPSS 22 and the significance level was considered 0.05. Results: In general, 71.1% of the subjects suffered from at least one musculoskeletal disorder in their organs during the past year. There was no significant relation between musculoskeletal disorders and occupational burnout. Musculoskeletal disorders were significantly associated with decreased motivation (P=0.035), one of the fatigue domains. Musculoskeletal disorders were also significantly related with the type of occupation (P = 0.017). Conclusion: Musculoskeletal disorders are probably related with some fields of fatigue and burnout. Further studies should be done. Keywords: Musculoskeletal Disorders, Fatigue, Occupational Burnout, Petrochemical

The Effectiveness of Combining Reality Therapy and Logo Therapy Approaches on the Quality of life and Psychological Adjustment of Female Householders

The present study aimed to investigate the Effectiveness of Combining two reality therapy and logo therapy approaches on quality of life and Psychological Adjustment of Female Householders. This research is a semi-experimental with pre-test and post-test with unequal control group. The research community consisted of all women householders covered by the Relief Committee of Mashhad who have been referred to the advisory committee of the Relief Committee in 1395. The sampling method was convenient sampling and the sample size was 30, and data was collected using questionnaires including World Health Organization Quality of Life and Psychological Adjustment Assessment Questionnaire (Adult Form) and consequently data were analyzed by 18 spss software. Results showed that, the mean scores of quality of life and psychological adjustment in the post test of the experimental group were significantly higher than the mean scores of post-test in the control group, while the findings of the covariance test showed that the difference between the pre-test and the post-test was significant. Therefore, it can be concluded that the combination and integration of therapeutic approaches related to clients' problems increases the effectiveness of treatment. Also, it was shown that the combination of  logo therapy and reality therapy the quality the life and psychological adjustment in female householders

Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae

The goal of this research was to investigate the potential of newly synthesized gold complex trichloro(2,4,6-trimethylpyridine)Au(III) as an anticancer agent. The gold(III) complex was synthesized and grafted on nanoporous silica, MCM-41, to produce AuCl3@PF-MCM- 41 (AuCl3 grafted on pyridine-functionalized MCM-41). The toxicity of trichloro(2,4,6- trimethylpyridine)Au(III) and AuCl3@PF-MCM-41 in Saccharomyces cerevisiae (as a model system) was studied. The gold(III) complex showed a mid cytotoxic effect on yeast viability. Using the drug delivery system, nanoporous MCM-41, the gold(III) complex became a strong inhibitor for growth of yeast cells at a very low concentration. Furthermore, the animal tests revealed a high uptake of AuCl3@PF-MCM-41 in tumor cells. The stability of the compound was confirmed in human serum

Development of ListeriaBase and comparative analysis of Listeria monocytogenes

Background: Listeria consists of both pathogenic and non-pathogenic species. Reports of similarities between the genomic content between some pathogenic and non-pathogenic species necessitates the investigation of these species at the genomic level to understand the evolution of virulence-associated genes. With Listeria genome data growing exponentially, comparative genomic analysis may give better insights into evolution, genetics and phylogeny of Listeria spp., leading to better management of the diseases caused by them. Description: With this motivation, we have developed ListeriaBase, a web Listeria genomic resource and analysis platform to facilitate comparative analysis of Listeria spp. ListeriaBase currently houses 850,402 protein-coding genes, 18,113 RNAs and 15,576 tRNAs from 285 genome sequences of different Listeria strains. An AJAX-based real time search system implemented in ListeriaBase facilitates searching of this huge genomic data. Our in-house designed comparative analysis tools such as Pairwise Genome Comparison (PGC) tool allowing comparison between two genomes, Pathogenomics Profiling Tool (PathoProT) for comparing the virulence genes, and ListeriaTree for phylogenic classification, were customized and incorporated in ListeriaBase facilitating comparative genomic analysis of Listeria spp. Interestingly, we identified a unique genomic feature in the L. monocytogenes genomes in our analysis. The Auto protein sequences of the serotype 4 and the non-serotype 4 strains of L. monocytogenes possessed unique sequence signatures that can differentiate the two groups. We propose that the aut gene may be a potential gene marker for differentiating the serotype 4 strains from other serotypes of L. monocytogenes. Conclusions: ListeriaBase is a useful resource and analysis platform that can facilitate comparative analysis of Listeria for the scientific communities. We have successfully demonstrated some key utilities of ListeriaBase. The knowledge that we obtained in the analyses of L. monocytogenes may be important for functional works of this human pathogen in future. ListeriaBase is currently available at http://listeria.um.edu.my

Quantum Corrections for a Braneworld Black Hole

By using the quantum tunneling approach over semiclassical approximations, we study the quantum corrections to the Hawking temperature, entropy and Bekenstein-Hawking entropy-area relation for a black hole lying on a brane.Comment: 8 pages, accepted for publication in IJTP, references adde

Brane-world black hole entropy from modified dispersion relations

The entropy of the Reissner-N\"{o}rdstrom black hole is studied within the context of a brane-world scenario. Such a black hole is a solution of the Einstein field equations on the brane, possessing a tidal charge which is a reflection of the extra dimension. We use the modified dispersion relation to obtain the entropy of such brane-world black holes. The resulting entropy differs from that of the standard Bekenstein-Hawking's and contains information on the extra dimension.Comment: 9 pages, 4 figures, to appear in PL

Development of ListeriaBase and comparative analysis of \u3ci\u3eListeria monocytogenes\u3c/i\u3e

Background: Listeria consists of both pathogenic and non-pathogenic species. Reports of similarities between the genomic content between some pathogenic and non-pathogenic species necessitates the investigation of these species at the genomic level to understand the evolution of virulence-associated genes. With Listeria genome data growing exponentially, comparative genomic analysis may give better insights into evolution, genetics and phylogeny of Listeria spp., leading to better management of the diseases caused by them. Description: With this motivation, we have developed ListeriaBase, a web Listeria genomic resource and analysis platform to facilitate comparative analysis of Listeria spp. ListeriaBase currently houses 850,402 protein-coding genes, 18,113 RNAs and 15,576 tRNAs from 285 genome sequences of different Listeria strains. An AJAX-based real time search system implemented in ListeriaBase facilitates searching of this huge genomic data. Our in-house designed comparative analysis tools such as Pairwise Genome Comparison (PGC) tool allowing comparison between two genomes, Pathogenomics Profiling Tool (PathoProT) for comparing the virulence genes, and ListeriaTree for phylogenic classification, were customized and incorporated in ListeriaBase facilitating comparative genomic analysis of Listeria spp. Interestingly, we identified a unique genomic feature in the L. monocytogenes genomes in our analysis. The Auto protein sequences of the serotype 4 and the non-serotype 4 strains of L. monocytogenes possessed unique sequence signatures that can differentiate the two groups. We propose that the aut gene may be a potential gene marker for differentiating the serotype 4 strains from other serotypes of L. monocytogenes. Conclusions: ListeriaBase is a useful resource and analysis platform that can facilitate comparative analysis of Listeria for the scientific communities. We have successfully demonstrated some key utilities of ListeriaBase. The knowledge that we obtained in the analyses of L. monocytogenes may be important for functional works of this human pathogen in future. ListeriaBase is currently available at http://listeria.um.edu.my

Predicting survival of Iranian COVID-19 patients infected by various variants including omicron from CT Scan images and clinical data using deep neural networks

Purpose: The rapid spread of the COVID-19 omicron variant virus has resulted in an overload of hospitals around the globe. As a result, many patients are deprived of hospital facilities, increasing mortality rates. Therefore, mortality rates can be reduced by efficiently assigning facilities to higher-risk patients. Therefore, it is crucial to estimate patients' survival probability based on their conditions at the time of admission so that the minimum required facilities can be provided, allowing more opportunities to be available for those who need them. Although radiologic findings in chest computerized tomography scans show various patterns, considering the individual risk factors and other underlying diseases, it is difficult to predict patient prognosis through routine clinical or statistical analysis. Method: In this study, a deep neural network model is proposed for predicting survival based on simple clinical features, blood tests, axial computerized tomography scan images of lungs, and the patients' planned treatment. The model's architecture combines a Convolutional Neural Network and a Long Short Term Memory network. The model was trained using 390 survivors and 108 deceased patients from the Rasoul Akram Hospital and evaluated 109 surviving and 36 deceased patients infected by the omicron variant. Results: The proposed model reached an accuracy of 87.5% on the test data, indicating survival prediction possibility. The accuracy was significantly higher than the accuracy achieved by classical machine learning methods without considering computerized tomography scan images (p-value &lt;= 4E-5). The images were also replaced with hand-crafted features related to the ratio of infected lung lobes used in classical machine-learning models. The highest-performing model reached an accuracy of 84.5%, which was considerably higher than the models trained on mere clinical information (p-value &lt;= 0.006). However, the performance was still significantly less than the deep model (p-value &lt;= 0.016). Conclusion: The proposed deep model achieved a higher accuracy than classical machine learning methods trained on features other than computerized tomography scan images. This proves the images contain extra information. Meanwhile, Artificial Intelligence methods with multimodal inputs can be more reliable and accurate than computerized tomography severity scores.</p

Induced inflation from a 5D purely kinetic scalar field formalism on warped product spaces

Considering a separable and purely kinetic 5D scalar field on a warped product metric background we propose a new and more general approach for inducing 4D scalar potentials on a 4D constant foliation of the 5D space-time. We obtain an induced potential for a true 4D scalar field instead of a potential for an effective 4D scalar field. In this formalism we can recover the usual 4D inflationary formalism with a geometrically induced inflationary potential. In addition the quantum confinement of the inflaton modes is obtained naturally from the model for at least a class of warping factors. Besides the 4D inflationary physics that results of this formalism is independent of the 4D-hypersurface chosen.Comment: 8 pages Accepted for publication in European Physical Journal