Quantized gravitational waves in the Milne universe

The quantization of gravitational waves in the Milne universe is discussed. The relation between positive frequency functions of the gravitational waves in the Milne universe and those in the Minkowski universe is clarified. Implications to the one-bubble open inflation scenario are also discussed.Comment: 26 pages, 1 figure, revtex. submitted to Phys. Rev. D1

Long-term efficacy and safety of migalastat treatment in Fabry disease: 30-month results from the open-label extension of the randomized, phase 3 ATTRACT study

Results from the 18-month randomized treatment period of the phase 3 ATTRACT study demonstrated the efficacy and safety of oral migalastat compared with enzyme replacement therapy (ERT) in patients with Fabry disease who previously received ERT. Here, we report data from the subsequent 12-month, migalastat-only, open-label extension (OLE) period. ATTRACT (Study AT1001–012; NCT01218659) was a randomized, open-label, active-controlled study in patients aged 16–74 years with Fabry disease, an amenable GLA variant, and an estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m2. During the OLE, patients who received migalastat 150 mg every other day (QOD) during the randomized period continued receiving migalastat (Group 1 [MM]); patients who received ERT every other week discontinued ERT and started migalastat treatment (Group 2 [EM]). Outcome measures included eGFR, left ventricular mass index (LVMi), composite clinical outcome (renal, cardiac or cerebrovascular events), and safety. Forty-six patients who completed the randomized treatment period continued into the OLE (Group 1 [MM], n = 31; Group 2 [EM], n = 15). eGFR remained stable in both treatment groups. LVMi decreased from baseline at month 30 in Group 1 (MM) in patients with left ventricular hypertrophy at baseline. Only 10% of patients experienced a new composite clinical event with migalastat treatment during the OLE. No new safety concerns were reported. In conclusion, in patients with Fabry disease and amenable GLA variants, migalastat 150 mg QOD was well tolerated and demonstrated durable, long-term stability of renal function and reduction in LVMi

Self Excitation of the Tunneling Scalar Field in False Vacuum Decay

A method to determine the quantum state of a scalar field after $O(4)$-symmetric bubble nucleation has been developed recently. The method has an advantage that it concisely gives us a clear picture of the resultant quantum state. In particular, one may interpret the excitations as a particle creation phenomenon just as in the case of particle creation in curved spacetime. As an application, we investigate in detail the spectrum of quantum excitations of the tunneling field when it undergoes false vacuum decay. We consider a tunneling potential which is piece-wise quadratic, hence is simple enough to allow us an analytical treatment. We find a strong dependence of the excitation spectrum upon the shape of the potential on the true vacuum side. We then discuss features of the excitation spectrum common to general tunneling potentials not restricted to our simple model.Comment: 24 pages, uuencoded compressed postscript fil

Evolution of Second-Order Cosmological Perturbations and Non-Gaussianity

We present a second-order gauge-invariant formalism to study the evolution of curvature perturbations in a Friedmann-Robertson-Walker universe filled by multiple interacting fluids. We apply such a general formalism to describe the evolution of the second-order curvature perturbations in the standard one-single field inflation, in the curvaton and in the inhomogeneous reheating scenarios for the generation of the cosmological perturbations. Moreover, we provide the exact expression for the second-order temperature anisotropies on large scales, including second-order gravitational effects and extend the well-known formula for the Sachs-Wolfe effect at linear order. Our findings clarify what is the exact non-linearity parameter f_NL entering in the determination of higher-order statistics such as the bispectrum of Cosmic Microwave Background temperature anisotropies. Finally, we compute the level of non-Gaussianity in each scenario for the creation of cosmological perturbations.Comment: 14 pages, LaTeX file. Further comments adde

Quantum fluctuations and CMB anisotropies in one-bubble open inflation models

We first develop a method to calculate a complete set of mode functions which describe the quantum fluctuations generated in one-bubble open inflation models. We consider two classes of models. One is a single scalar field model proposed by Bucher, Goldhaber and Turok and by us as an example of the open inflation scinario, and the other is a two-field model such as the ``supernatural'' inflation proposed by Linde and Mezhlumian. In both cases we assume the difference in the vacuum energy density between inside and outside the bubble is negligible. There are two kinds of mode functions. One kind has usual continuous spectrum and the other has discrete spectrum with characteristic wavelengths exceeding the spatial curvature scale. The latter can be further devided into two classes in terms of its origin. One is called the de Sitter super-curvature mode, which arises due to the global spacetime structure of de Sitter space, and the other is due to fluctuations of the bubble wall. We calculate the spectrum of quantum fluctuations in these models and evaluate the resulting large angular scale CMB anisotropies. We find there are ranges of model parameters that are consistent with observed CMB anisotropies.Comment: 22 pages revtex file, 12 postscript figures, tarred, gzippe

Cosmological Perturbations with Multiple Fluids and Fields

We consider the evolution of perturbed cosmological spacetime with multiple fluids and fields in Einstein gravity. Equations are presented in gauge-ready forms, and are presented in various forms using the curvature (\Phi or \phi_\chi) and isocurvature (S_{(ij)} or \delta \phi_{(ij)}) perturbation variables in the general background with K and \Lambda. We clarify the conditions for conserved curvature and isocurvature perturbations in the large-scale limit. Evolutions of curvature perturbations in many different gauge conditions are analysed extensively. In the multi-field system we present a general solution to the linear order in slow-roll parameters.Comment: 19 pages, 6 figures, revised thoroughly; published version in Class. Quant. Gra

Primordial Gravitational Waves From Open Inflation

We calculate the spectrum of gravitational waves generated during inflation in open $(\Omega _0<1)$ inflationary models. In such models an initial epoch of old inflation solves the horizon and flatness problems, and during this first epoch of inflation the quantum state of the graviton field rapidly approaches the Bunch-Davies vacuum. Then old inflation ends by the nucleation of a single bubble, inside of which there is a shortened epoch of slow-roll inflation giving $\Omega _0<1$ today. In this paper we re-express the Bunch-Davies vacuum for the graviton field in terms of the hyperbolic modes inside the bubble and propagate these modes forward in time into the present era. We derive the expression for the contribution from these gravity waves to the cosmic microwave background anisotropy including the effect of a finite energy difference across the bubble wall.Comment: 40 pages, TEX with phyzzx macro, 5 figure

Cosmological perturbations from varying masses and couplings

We study the evolution of perturbations during the domination and decay of a massive particle species whose mass and decay rate are allowed to depend on the expectation value of a light scalar field. We specialize in the case where the light field is slow-rolling, showing that during a phase of inhomogeneous mass-domination and decay the isocurvature perturbation of the light field is converted into a curvature perturbation with an efficiency which is nine times larger than when the mass is fixed. We derive a condition on the annihilation cross section and on the decay rate for the domination of the massive particles and we show that standard model particles cannot dominate the universe before nucleosynthesis. We also compare this mechanism with the curvaton model. Finally, observational signatures are discussed. A cold dark matter isocurvature mode can be generated if the dark matter is produced out of equilibrium by both the inflaton and the massive particle species decay. Non-Gaussianities are present: they are chi-square deviations. However, they might be too small to be observable.Comment: 21 pages, 4 figures, published versio

Exact Tunneling Solutions in Minkowski Spacetime and a Candidate for Dark Energy

We study exact tunneling solutions in scalar field theory for potential barriers composed of linear or quadratic patches. We analytically continue our solutions to imaginary Euclidean radius in order to study the profile of the scalar field inside the growing bubble. We find that generally there is a non-trivial profile of the scalar field, generating a stress-energy tensor, that depending on the form of the potential, can be a candidate for dark energy.Comment: 39 pages, 12 figure

Complete power spectrum for an induced gravity open inflation model

We study the phenomenological constraints on a recently proposed model of open inflation in the context of induced gravity. The main interest of this model is the relatively small number of parameters, which may be constrained by many different types of observation. We evaluate the complete spectrum of density perturbations, which contains continuum sub-curvature modes, a discrete super curvature mode, and a mode associated with fluctuations in the bubble wall. From these, we compute the angular power spectrum of temperature fluctuations in the microwave background, and derive bounds on the parameters of the model so that the predicted spectrum is compatible with the observed anisotropy of the microwave background and with large-scale structure observations. We analyze the matter era and the approach of the model to general relativity. The model passes all existing constraints.Comment: 12 pages RevTeX file with four figures incorporated (uses RevTeX and epsf). Also available by e-mailing ARL, or by WWW at http://star-www.maps.susx.ac.uk/papers/early_papers.html Only change is additional reference