Lightning-jumps in convective cells tracked by radar as a nowcasting tool in complex orography

Presentación realizada en la 3rd European Nowcasting Conference, celebrada en la sede central de AEMET en Madrid del 24 al 26 de abril de 2019

Immune modulation and prevention of autoimmune disease by repeated sequences from parasites linked to self antigens

Parasite proteins containing repeats are essential invasion ligands, important for their ability to evade the host immune system and to induce immunosuppression. Here, the intrinsic suppressive potential of repetitive structures within parasite proteins was exploited to induce immunomodulation in order to establish self-tolerance in an animal model of autoimmune neurological disease. We tested the tolerogenic potential of fusion proteins containing repeat sequences of parasites linked to self-antigens. The fusion constructs consist of a recombinant protein containing repeat sequences derived from the S-antigen protein (SAg) of Plasmodium falciparum linked to a CD4 T cell epitope of myelin. They were tested for their efficacy to control the development of experimental autoimmune encephalomyelitis (EAE), In addition, we used the DO11.10 transgenic mouse model to study the immune mechanisms involved in tolerance induced by SAg fusion proteins. We found that repeated sequences of P. falciparum SAg protein linked to self-epitopes markedly protected mice from EAE. These fusion constructs were powerful tolerizing agents not only in a preventive setting but also in the treatment of ongoing disease. The tolerogenic effect was shown to be antigen-specific and strongly dependent on the physical linkage of the T cell epitope to the parasite structure and on the action of anti-inflammatory cytokines like IL-10 and TGF-{beta}. Other mechanisms include down-regulation of TNF-{alpha} accompanied by increased numbers of FoxP3(+) cells. This study describes the use of repetitive structures from parasites linked to defined T cell epitopes as an effective method to induce antigen-specific tolerance with potential applicability for the treatment and prevention of autoimmune diseases

Evidence for a Kondo destroying quantum critical point in YbRh2Si2

The heavy-fermion metal YbRh$_{2}$Si$_{2}$ is a weak antiferromagnet below $T_{N} = 0.07$ K. Application of a low magnetic field $B_{c} = 0.06$ T ($\perp c$) is sufficient to continuously suppress the antiferromagnetic (AF) order. Below $T \approx 10$ K, the Sommerfeld coefficient of the electronic specific heat $\gamma(T)$ exhibits a logarithmic divergence. At $T < 0.3$ K, $\gamma(T) \sim T^{-\epsilon}$ ($\epsilon: 0.3 - 0.4$), while the electrical resistivity $\rho(T) = \rho_{0} + aT$ ($\rho_{0}$: residual resistivity). Upon extrapolating finite-$T$ data of transport and thermodynamic quantities to $T = 0$, one observes (i) a vanishing of the "Fermi surface crossover" scale $T^{*}(B)$, (ii) an abrupt jump of the initial Hall coefficient $R_{H}(B)$ and (iii) a violation of the Wiedemann Franz law at $B = B_{c}$, the field-induced quantum critical point (QCP). These observations are interpreted as evidence of a critical destruction of the heavy quasiparticles, i.e., propagating Kondo singlets, at the QCP of this material.Comment: 20 pages, 8 figures, SCES 201

Constraining Light Gravitino Mass from Cosmic Microwave Background

We investigate the possibilities of constraining the light gravitino mass m_{3/2} from future cosmic microwave background (CMB) surveys. A model with light gravitino with the mass m_{3/2}<O(10) eV is of great interest since it is free from the cosmological gravitino problem and, in addition, can be compatible with many baryogenesis/leptogenesis scenarios such as the thermal leptogenesis. We show that the lensing of CMB anisotropies can be a good probe for m_{3/2} and obtain an expected constraint on m_{3/2} from precise measurements of lensing potential in the future CMB surveys, such as the PolarBeaR and CMBpol experiments. If the gravitino mass is m_{3/2}=1 eV, we will obtain the constraint for the gravitino mass as m_{3/2} < 3.2 eV (95% C.L.) for the case with Planck+PolarBeaR combined and m_{3/2}=1.04^{+0.22}_{-0.26} eV (68% C.L.) for CMBpol. The issue of Bayesian model selection is also discussed.Comment: 22 pages, 6 figures, 7 tables, references are added, accepted for publication in JCA

Effects of the stellar wind on X-ray spectra of Cygnus X-3

We study X-ray spectra of Cyg X-3 from BeppoSAX, taking into account absorption and emission in the strong stellar wind of its companion. We find the intrinsic X-ray spectra are well modelled by disc blackbody emission, its upscattering by hot electrons with a hybrid distribution, and by Compton reflection. These spectra are strongly modified by absorption and reprocessing in the stellar wind, which we model using the photoionization code cloudy. The form of the observed spectra implies the wind is composed of two phases. A hot tenuous plasma containing most of the wind mass is required to account for the observed features of very strongly ionized Fe. Small dense cool clumps filling <0.01 of the volume are required to absorb the soft X-ray excess, which is emitted by the hot phase but not present in the data. The total mass-loss rate is found to be (0.6--1.6) x 10^-5 solar masses per year. We also discuss the feasibility of the continuum model dominated by Compton reflection, which we find to best describe our data. The intrinsic luminosities of our models suggest that the compact object is a black hole.Comment: MNRAS, in pres

The Cosmic Neutrino Background and the Age of the Universe

We discuss the cosmological degeneracy between the age of the Universe, the Hubble parameter and the effective number of relativistic particles N_eff. We show that independent determinations of the Hubble parameter H(z) as those recently provided by Simon,Verde, Jimenez (2006), combined with other cosmological data sets can provide the most stringent constraint on N_eff, yielding N_eff=3.7 (-1.2) (+1.1) at 95% confidence level. A neutrino background is detected with high significance: N_eff >1.8 at better than 99% confidence level. Constraints on the age of the universe in the framework of an extra background of relativistic particles are improved by a factor 3.Comment: JCAP, in pres

Far-UV Spectroscopic Analyses of Four Central Stars of Planetary Nebulae

We analyze the Far-UV/UV spectra of four central stars of planetary nebulae with strong wind features -- NGC 2371, Abell 78, IC 4776 and NGC 1535, and derive their photospheric and wind parameters by modeling high-resolution FUSE (Far-Ultraviolet Spectroscopic Explorer) data in the Far-UV and HST-STIS and IUE data in the UV with spherical non-LTE line-blanketed model atmospheres. Abell 78 is a hydrogen-deficient transitional [WR]-PG 1159 object, and we find NGC 2371 to be in the same stage, both migrating from the constant-luminosity phase to the white dwarf cooling sequence with Teff ~= 120 kK, Mdot ~= 5x10^-8 Msun/yr. NGC 1535 is a ``hydrogen-rich'' O(H) CSPN, and the exact nature of IC 4776 is ambiguous, although it appears to be helium burning. Both objects lie on the constant-luminosity branch of post-AGB evolution and have Teff ~= 65 kK, Mdot ~= 1x10^-8 Msun/yr. Thus, both the H-rich and H-deficient channels of PN evolution are represented in our sample. We also investigate the effects of including higher ionization stages of iron (up to FeX) in the model atmosphere calculations of these hot objects (usually neglected in previous analyses), and find iron to be a useful diagnostic of the stellar parameters in some cases. The Far-UV spectra of all four objects show evidence of hot (T ~ 300 K) molecular hydrogen in their circumstellar environments.Comment: 38 pages, 8 figures (6 color). Accepted for publication in Ap

Central Stars of Planetary Nebulae in the Large Magellanic Cloud: A Far-UV Spectroscopic Analysis

We observed seven central stars of planetary nebulae (CSPN) in the Large Magellanic Cloud (LMC) with the Far Ultraviolet Spectroscopic Explorer (FUSE), and performed a model-based analysis of these spectra in conjunction with Hubble Space Telescope (HST) spectra in the UV and optical range to determine the stellar and nebular parameters. Most of the objects show wind features, and they have effective temperatures ranging from 38 to 60 kK with mass-loss rates of ~= 5x10^-8 Msun/yr. Five of the objects have typical LMC abundances. One object (SMP LMC 61) is a [WC4] star, and we fit its spectra with He/C/O-rich abundances typical of the [WC] class, and find its atmosphere to be iron-deficient. Most objects have very hot (T ~> 2000 K) molecular hydrogen in their nebulae, which may indicate a shocked environment. One of these (SMP LMC 62) also displays OVI 1032-38 nebular emission lines, rarely observed in PN.Comment: 53 pages, 15 figures (11 color). Accepted for publication in Ap

Nowcasting of thunderstorm severity with Machine Learning in the Alpine Region

Presentación realizada en la 3rd European Nowcasting Conference, celebrada en la sede central de AEMET en Madrid del 24 al 26 de abril de 2019