Mutualisation logistique, approche par simulation

International audienceRESUME : La mutualisation logistique est considérée comme l'une des solutions innovantes pour relever efficacement les défis logistiques croissants et améliorer le développement durable. Elle a déjà montré sa performance dans la revue de littérature scientifique en terme économique par la diminution des coûts et en terme environnemental par la minimisation des émissions des gaz à effet de serre. Dans cette étude, nous allons proposer un modèle de simulation générique pour une chaîne logistique mutualisée. Puis, nous traiterons un exemple afin de démontrer la performance de ce type de collaboration en évaluant les indicateurs économiques (coût de transport, coût de chargement, coût de déchargement et taux de remplissage des véhicules) et les indicateurs environnementaux sous forme d'émissions de CO2. Finalement, nous présentons une comparaison des résultats avec la chaîne logistique traditionnelle. MOTS-CLES : Mutualisation logistique, développement durable, simulation

THE INFLUENCE OF INDIUM DOPING ON STRUCTURAL, OPTICAL AND ELECTRICAL PROPERTIES OF SnO2:IN THIN FILMS DEPOSITED BY SPRAY TECHNIQUE

In this present work, undoped and Indium doped tin dioxide were deposited on glass substrate by Ultrasonic spray method. We investigated the effect of deposition conditions to obtain In doped SnO2 thin films with various concentration (1 to 8 wt.%). XRD analysis confirmed that SnO2 thin films crystallize in the tetragonal structure of SnO2. The grain size average decreases with In content increase. We found that the maximum films transmittance varies from 65-93% in the visible range of the spectrum. The films optical gap varies between 3.48 and 3.80 eV. However, we have noticed that the sheet resistance increases up to 880*103 (Ω/sqr) with increasing the in doping concentration. Owing to their high optical gap and high sheet resistance; the prepared films can be employed in optoelectronic devices

Scalar models for the generalized Chaplygin gas and the structure formation constraints

The generalized Chaplygin gas model represents an attempt to unify dark matter and dark energy. It is characterized by a fluid with an equation of state $p = - A/\rho^\alpha$. It can be obtained from a generalization of the DBI action for a scalar, tachyonic field. At background level, this model gives very good results, but it suffers from many drawbacks at perturbative level. We show that, while for background analysis it is possible to consider any value for $\alpha$, the perturbative analysis must be restricted to positive values of $\alpha$. This restriction can be circumvented if the origin of the generalized Chaplygin gas is traced back to a self-interacting scalar field, instead of the DBI action. But, in doing so, the predictions coming from formation of large scale structures reduce the generalized Chaplygin gas model to a kind of quintessence model, and the unification scenario is lost, if the scalar field is the canonical one. However, if the unification condition is imposed from the beginning as a prior, the model may remain competitive. More interesting results, concerning the unification program, are obtained if a non-canonical self-interacting scalar field, inspired by Rastall's theory of gravity, is imposed. In this case, an agreement with the background tests is possible.Comment: Latex file, 25 pages, 33 figures in eps format. New section on scalar models. Accepted for publication in Gravitation&Cosmolog

MiRNA-Mediated Control of HLA-G Expression and Function

HLA-G is a non-classical HLA class-Ib molecule expressed mainly by the extravillous cytotrophoblasts (EVT) of the placenta. The expression of HLA-G on these fetal cells protects the EVT cells from immune rejection and is therefore important for a healthy pregnancy. The mechanisms controlling HLA-G expression are largely unknown. Here we demonstrate that miR-148a and miR-152 down-regulate HLA-G expression by binding its 3′UTR and that this down-regulation of HLA-G affects LILRB1 recognition and consequently, abolishes the LILRB1-mediated inhibition of NK cell killing. We further demonstrate that the C/G polymorphism at position +3142 of HLA-G 3′UTR has no effect on the miRNA targeting of HLA-G. We show that in the placenta both miR-148a and miR-152 miRNAs are expressed at relatively low levels, compared to other healthy tissues, and that the mRNA levels of HLA-G are particularly high and we therefore suggest that this might enable the tissue specific expression of HLA-G

Does Pilocarpine-Induced Epilepsy in Adult Rats Require Status epilepticus?

Pilocarpine-induced seizures in rats provide a widely animal model of temporal lobe epilepsy. Some evidences reported in the literature suggest that at least 1 h of status epilepticus (SE) is required to produce subsequent chronic phase, due to the SE-related acute neuronal damage. However, recent data seems to indicate that neuro-inflammation plays a crucial role in epileptogenesis, modulating secondarily a neuronal insult. For this reason, we decided to test the following hypotheses: a) whether pilocarpine-injected rats that did not develop SE can exhibit long-term chronic spontaneous recurrent seizures (SRS) and b) whether acute neurodegeneration is mandatory to obtain chronic epilepsy. Therefore, we compared animals injected with the same dose of pilocarpine that developed or did not SE, and saline treated rats. We used telemetric acquisition of EEG as long-term monitoring system to evaluate the occurrence of seizures in non-SE pilocarpineinjected animals. Furthermore, histology and MRI analysis were applied in order to detect neuronal injury and neuropathological signs. Our observations indicate that non-SE rats exhibit SRS almost 8 (+/22) months after pilocarpine-injection, independently to the absence of initial acute neuronal injury. This is the first time reported that pilocarpine injected rats without developing SE, can experience SRS after a long latency period resembling human pathology. Thus, we strongly emphasize the important meaning of including these animals to model human epileptogenesis in pilocarpine induced epilepsy

Basal ganglia dysfunction in OCD: subthalamic neuronal activity correlates with symptoms severity and predicts high-frequency stimulation efficacy

Functional and connectivity changes in corticostriatal systems have been reported in the brains of patients with obsessive–compulsive disorder (OCD); however, the relationship between basal ganglia activity and OCD severity has never been adequately established. We recently showed that deep brain stimulation of the subthalamic nucleus (STN), a central basal ganglia nucleus, improves OCD. Here, single-unit subthalamic neuronal activity was analysed in 12 OCD patients, in relation to the severity of obsessions and compulsions and response to STN stimulation, and compared with that obtained in 12 patients with Parkinson's disease (PD). STN neurons in OCD patients had lower discharge frequency than those in PD patients, with a similar proportion of burst-type activity (69 vs 67%). Oscillatory activity was present in 46 and 68% of neurons in OCD and PD patients, respectively, predominantly in the low-frequency band (1–8 Hz). In OCD patients, the bursty and oscillatory subthalamic neuronal activity was mainly located in the associative–limbic part. Both OCD severity and clinical improvement following STN stimulation were related to the STN neuronal activity. In patients with the most severe OCD, STN neurons exhibited bursts with shorter duration and interburst interval, but higher intraburst frequency, and more oscillations in the low-frequency bands. In patients with best clinical outcome with STN stimulation, STN neurons displayed higher mean discharge, burst and intraburst frequencies, and lower interburst interval. These findings are consistent with the hypothesis of a dysfunction in the associative–limbic subdivision of the basal ganglia circuitry in OCD's pathophysiology

Finding the engram.

Many attempts have been made to localize the physical trace of a memory, or engram, in the brain. However, until recently, engrams have remained largely elusive. In this Review, we develop four defining criteria that enable us to critically assess the recent progress that has been made towards finding the engram. Recent \u27capture\u27 studies use novel approaches to tag populations of neurons that are active during memory encoding, thereby allowing these engram-associated neurons to be manipulated at later times. We propose that findings from these capture studies represent considerable progress in allowing us to observe, erase and express the engram

Parkinson’s disease mouse models in translational research

Animal models with high predictive power are a prerequisite for translational research. The closer the similarity of a model to Parkinson’s disease (PD), the higher is the predictive value for clinical trials. An ideal PD model should present behavioral signs and pathology that resemble the human disease. The increasing understanding of PD stratification and etiology, however, complicates the choice of adequate animal models for preclinical studies. An ultimate mouse model, relevant to address all PD-related questions, is yet to be developed. However, many of the existing models are useful in answering specific questions. An appropriate model should be chosen after considering both the context of the research and the model properties. This review addresses the validity, strengths, and limitations of current PD mouse models for translational research

Competitive Tendering In The Netherlands: Central Planning Or Functional Specifications?

Institute of Transport and Logistics Studies. Faculty of Economics and Business. The University of Sydne