620 research outputs found
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Machine learning analysis for quantitative discrimination of dried blood droplets
One of the most interesting and everyday natural phenomenon is the formation of different patterns after the evaporation of liquid droplets on a solid surface. The analysis of dried patterns from blood droplets has recently gained a lot of attention, experimentally and theoretically, due to its potential application in diagnostic medicine and forensic science. This paper presents evidence that images of dried blood droplets have a signature revealing the exhaustion level of the person, and discloses an entirely novel approach to studying human dried blood droplet patterns. We took blood samples from 30 healthy young male volunteers before and after exhaustive exercise, which is well known to cause large changes to blood chemistry. We objectively and quantitatively analysed 1800 images of dried blood droplets, developing sophisticated image processing analysis routines and optimising a multivariate statistical machine learning algorithm. We looked for statistically relevant correlations between the patterns in the dried blood droplets and exercise-induced changes in blood chemistry. An analysis of the various measured physiological parameters was also investigated. We found that when our machine learning algorithm, which optimises a statistical model combining Principal Component Analysis (PCA) as an unsupervised learning method and Linear Discriminant Analysis (LDA) as a supervised learning method, is applied on the logarithmic power spectrum of the images, it can provide up to 95% prediction accuracy, in discriminating the physiological conditions, i.e., before or after physical exercise. This correlation is strongest when all ten images taken per volunteer per condition are averaged, rather than treated individually. Having demonstrated proof-of-principle, this method can be applied to identify diseases
Electronic control of the spin-wave damping in a magnetic insulator
It is demonstrated that the decay time of spin-wave modes existing in a
magnetic insulator can be reduced or enhanced by injecting an in-plane dc
current, , in an adjacent normal metal with strong spin-orbit
interaction. The demonstration rests upon the measurement of the ferromagnetic
resonance linewidth as a function of in a 5~m diameter
YIG(20nm){\textbar}Pt(7nm) disk using a magnetic resonance force microscope
(MRFM). Complete compensation of the damping of the fundamental mode is
obtained for a current density of , in
agreement with theoretical predictions. At this critical threshold the MRFM
detects a small change of static magnetization, a behavior consistent with the
onset of an auto-oscillation regime.Comment: 6 pages 4 figure
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Enhancing the sustainability and energy conservation in heritage buildings: the case of Nottingham Playhouse
Today, there is a growing interest in developing energy efficient buildings since it is estimated that buildings account for about 40% of the total primary energy consumption in the world. In relation to existing buildings, energy efficiency retrofits have become an important opportunity to upgrade the energy performance of commercial, public and residential buildings that may reduce the energy consumption, demand and cost. In this paper we cover the energy efficiency deep retrofit process that has been carried out for Nottingham Playhouse theatre building for the aim of enhancing its environmental performance and analysing the energy efficiency gained after implementing certain proposed modifications. It is a nationally protected historic building, listed as Grade II* on The National Heritage List for England (NHLE). The building has had insulation enhancement, doors modifications, solar energy installations, energy-saving lights, in addition to improved heating and air conditioning system. The paper presents a novel methodology; and its results indicate significant improvements in the building's energy performance which is demonstrated using infrared thermographic images and data logger sensors where significant energy savings to the building's thermal performance are obtained. The energy saving measures have been completed while maintaining the heritage building's general appearance and architectural features, which have received a Commendation Certificate from The Nottingham Civic Society for this achievement
A Novel Statistical Algorithm for Gene Expression Analysis Helps Differentiate Pregnane X Receptor-Dependent and Independent Mechanisms of Toxicity
Genome-wide gene expression profiling has become standard for assessing potential liabilities as well as for elucidating mechanisms of toxicity of drug candidates under development. Analysis of microarray data is often challenging due to the lack of a statistical model that is amenable to biological variation in a small number of samples. Here we present a novel non-parametric algorithm that requires minimal assumptions about the data distribution. Our method for determining differential expression consists of two steps: 1) We apply a nominal threshold on fold change and platform p-value to designate whether a gene is differentially expressed in each treated and control sample relative to the averaged control pool, and 2) We compared the number of samples satisfying criteria in step 1 between the treated and control groups to estimate the statistical significance based on a null distribution established by sample permutations. The method captures group effect without being too sensitive to anomalies as it allows tolerance for potential non-responders in the treatment group and outliers in the control group. Performance and results of this method were compared with the Significant Analysis of Microarrays (SAM) method. These two methods were applied to investigate hepatic transcriptional responses of wild-type (PXR+/+) and pregnane X receptor-knockout (PXRβ/β) mice after 96 h exposure to CMP013, an inhibitor of Ξ²-secretase (Ξ²-site of amyloid precursor protein cleaving enzyme 1 or BACE1). Our results showed that CMP013 led to transcriptional changes in hallmark PXR-regulated genes and induced a cascade of gene expression changes that explained the hepatomegaly observed only in PXR+/+ animals. Comparison of concordant expression changes between PXR+/+ and PXRβ/β mice also suggested a PXR-independent association between CMP013 and perturbations to cellular stress, lipid metabolism, and biliary transport
Feedback control architecture and the bacterial chemotaxis network.
PMCID: PMC3088647This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Bacteria move towards favourable and away from toxic environments by changing their swimming pattern. This response is regulated by the chemotaxis signalling pathway, which has an important feature: it uses feedback to 'reset' (adapt) the bacterial sensing ability, which allows the bacteria to sense a range of background environmental changes. The role of this feedback has been studied extensively in the simple chemotaxis pathway of Escherichia coli. However it has been recently found that the majority of bacteria have multiple chemotaxis homologues of the E. coli proteins, resulting in more complex pathways. In this paper we investigate the configuration and role of feedback in Rhodobacter sphaeroides, a bacterium containing multiple homologues of the chemotaxis proteins found in E. coli. Multiple proteins could produce different possible feedback configurations, each having different chemotactic performance qualities and levels of robustness to variations and uncertainties in biological parameters and to intracellular noise. We develop four models corresponding to different feedback configurations. Using a series of carefully designed experiments we discriminate between these models and invalidate three of them. When these models are examined in terms of robustness to noise and parametric uncertainties, we find that the non-invalidated model is superior to the others. Moreover, it has a 'cascade control' feedback architecture which is used extensively in engineering to improve system performance, including robustness. Given that the majority of bacteria are known to have multiple chemotaxis pathways, in this paper we show that some feedback architectures allow them to have better performance than others. In particular, cascade control may be an important feature in achieving robust functionality in more complex signalling pathways and in improving their performance
ΠΠΌΠΌΠΎΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΈΡ Π ΠΠ Π² ΠΏΠ΅ΡΠΎΠ²ΡΠΊΠΈΡΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΡΡ ΠΌΠ°ΡΡΠΈΡΡ
ΠΡΠΏΡΡΠΊΠ½Π°Ρ ΠΊΠ²Π°Π»ΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ°Π±ΠΎΡΠ° Ρ., ΡΠΈΡ., ΡΠ°Π±Π»., ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ², ΠΏΡΠΈΠ».
ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: ΠΏΠ΅ΡΠΎΠ²ΡΠΊΠΈΡ, ΠΈΠΌΠΌΠΎΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΈΡ ΡΠ°Π΄ΠΈΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΡ
ΠΎΡΡ
ΠΎΠ΄ΠΎΠ², ΡΠ°ΠΌΠΎΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½ΡΡΡΠΈΠΉΡΡ Π²ΡΡΠΎΠΊΠΎΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ½ΡΠΉ ΡΠΈΠ½ΡΠ΅Π·, ΠΌΠ°ΡΡΠΈΡΠ½ΡΠ΅ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ
ΠΠ±ΡΠ΅ΠΊΡΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΠΌΠΌΠΎΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΈΡ ΡΠ°Π΄ΠΈΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΡ
ΠΎΡΡ
ΠΎΠ΄ΠΎΠ² Π² ΠΌΠ°ΡΡΠΈΡΠ½ΡΠΉ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π‘ΠΠ‘ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΠ΅ΡΠΎΠ²ΡΠΊΠΈΡΠ°.
Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΠΉ ΠΌΠ°ΡΡΠΈΡΡ Π΄Π»Ρ ΠΈΠΌΠΌΠΎΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΈΠΈ Π°ΠΊΡΠΈΠ½ΠΎΠΈΠ΄Π½ΠΎΠΉ ΡΡΠ°ΠΊΡΠΈΠΈ ΡΠ°Π΄ΠΈΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΡ
ΠΎΡΡ
ΠΎΠ΄ΠΎΠ² ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π‘ΠΠ‘
Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΠΌΠ°Π³ΠΈΡΡΠ΅ΡΡΠΊΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΠΈ ΠΎΡΡΠ°Π±ΠΎΡΠ°Π½Π° ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΌΠ°ΡΡΠΈΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π‘ΠΠ‘. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ»ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠΈ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΡΠ°Π· ΡΠΎΡΡΠ°Π²Π° ΠΌΠ°ΡΡΠΈΡ.
Π‘ΡΠ΅ΠΏΠ΅Π½Ρ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΡ: ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΈΠΌΠΌΠΎΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΈΠΈ Π°ΠΊΡΠΈΠ½ΠΎΠΈΠ΄Π½ΠΎΠΉ ΡΡΠ°ΠΊΡΠΈΠΈ ΡΠ°Π΄ΠΈΠΎΠ°ΠΊΡΠΈΠ²Π½ΡΡ
ΠΎΡΡ
ΠΎΠ΄ΠΎΠ² ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π‘ΠΠ‘
ΠΠ±Π»Π°ΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ: Π°ΡFinal qualifying work with., Fig., Tab., Sources, adj.
Keywords: perovskite, radioactive waste immobilization, self-propagating high-temperature synthesis, matrix materials
The object of research is the immobilization of radioactive waste in the matrix material by the SHS-based perovskite.
The purpose of work - to obtain a chemically stable matrix for the immobilization of actinide fraction of radioactive waste by SHS
In carrying out the master's thesis the technology of producing the matrix material by SHS. The study of the formation of the composition of the matrix phase have been identified.
Degree of implementation: the organization of the process of immobilization actinide fraction of radioactive waste by SHS
Scope: the nuclear industry
Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapyβAn observational Ponte di Legno Toxicity Working Group Study
\ua9 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.Steroids are a mainstay in the treatment of acute lymphoblastic leukaemia (ALL) in children and adolescents; however, their use can cause clinically significant steroid-related neuropsychiatric symptoms (SRNS). As current knowledge on SRNS during ALL treatment is limited, we mapped the phenotypes, occurrence and treatment strategies using a database created by the international Ponte di Legno Neurotoxicity Working Group including data on toxicity in the central nervous system (CNS) in patients treated with frontline ALL protocols between 2000 and 2017. Ninety-four of 1813 patients in the CNS toxicity database (5.2%) experienced clinically significant SRNS with two peaks: one during induction and one during intensification phase. Dexamethasone was implicated in 86% of SRNS episodes. The most common symptoms were psychosis (52%), agitation (44%) and aggression (31%). Pharmacological treatment, mainly antipsychotics and benzodiazepines, was given to 87% of patients while 38% were hospitalised due to their symptoms. Recurrence of symptoms was reported in 29% of patients and two previously healthy patients required ongoing pharmacological treatment at the last follow up. Awareness of SRNS during ALL treatment and recommendation on treatment strategies merit further studies and consensus
Outcomes of patients with childhood B-cell precursor acute lymphoblastic leukaemia with late bone marrow relapses: long-term follow-up of the ALLR3 open-label randomised trial
Background: The ALLR3 trial investigated outcomes of children with B-cell precursor acute lymphoblastic leukaemia who had late bone marrow relapses. We analysed long-term follow-up outcomes of these patients. Methods: ALLR3 was an open-label randomised clinical trial that recruited children aged 1-18 years with B-cell precursor acute lymphoblastic leukaemia who had late bone marrow relapses. Eligible patients were recruited from centres in Australia, Ireland, the Netherlands, New Zealand, and the UK. Patients were randomly assigned from Jan 31, 2003, to Dec 31, 2007, and the trial closed to recruitment on Oct 31, 2013. Randomly assigned patients were allocated to receive either idarubicin or mitoxantrone in induction by stratified concealed randomisation; after randomisation stopped in Dec 31, 2007, all patients were allocated to receive mitoxantrone. After three blocks of therapy, patients with high minimal residual disease (β₯10-4 cells) at the end of induction were allocated to undergo allogeneic stem-cell transplantation and those with low minimal residual disease (<10-4 cells) at the end of induction were allocated to receive chemotherapy. Minimal residual disease level was measured by real-time quantitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements. The primary endpoint of the original ALLR3 clinical trial was progression-free survival of randomly assigned patients. The primary endpoint of this long-term follow-up analysis was progression-free survival of patients with late bone marrow relapses stratified by minimal residual disease level. Outcomes were correlated with age, site, time to recurrence, and genetic subtypes, and analysed by both intention to treat and actual treatment received. This trial is registered on the ISRCTN registry, number ISRCTN45724312, and on ClinicalTrials.gov, number NCT00967057. Findings: Between Feb 2, 2003, and Oct 28, 2013, 228 patients with B-cell precursor acute lymphoblastic leukaemia and late bone marrow relapses were treated. After a median follow-up of 84 months (IQR 48-109), progression-free survival of all randomly assigned patients was 60% (95% CI 54-70). 220 patients achieved second complete remission, and minimal residual disease was evaluable in 192 (87%). 110 patients with late bone marrow relapses and high minimal residual disease at the end of induction were allocated to undergo stem-cell transplantation, and 82 patients with low minimal residual disease at the end of induction were allocated to receive chemotherapy. In the patients allocated to undergo stem-cell transplantation, four relapses and three deaths were reported before the procedure, and 11 patients were not transplanted. Of the 92 patients transplanted, 58 (63%) remained in second complete remission, 13 (14%) died of complications, and 21 (23%) relapsed after stem-cell transplantation. In patients allocated to receive chemotherapy, one early treatment-related death was reported and 11 patients were transplanted. Of the 70 patients who continued on chemotherapy, 49 (70%) remained in second complete remission, two (3%) died of complications, and 19 (27%) relapsed. Progression-free survival at 5 years was 56% (95% CI 46-65) in those with high minimal residual disease and 72% (60-81) in patients with low minimal residual disease (p=0Β·0078). Treatment-related serious adverse events were not analysed in the long-term follow-up. Iinterpretation: Patients with B-cell precursor acute lymphoblastic leukaemia with late bone marrow relapses and low minimal residual disease at end of induction had favourable outcomes with chemotherapy without undergoing stem-cell transplantation. Patients with high minimal residual disease benefited from stem-cell transplantation, and targeted therapies might offer further improvements in outcomes for these patients.Catriona Parker, Shekhar Krishnan, Lina Hamadeh, Julie AE Irving, Roland P Kuiper, Tamas RΓ©vΓ©sz, Peter Hoogerbrugge, Jeremy Hancock, Rosemary Sutton, Anthony V Moorman, Vaskar Sah
Π Π°Π·ΡΠ°Π±ΠΎΡΠΊΠ° Π½ΠΎΠ²ΡΡ Π²ΠΈΠ΄ΠΎΠ² ΡΠΎΡΠ±ΡΠΈΠΎΠ½Π½ΡΡ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² Π½Π° ΠΌΠΈΠ½Π΅ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΎΡΠ½ΠΎΠ²Π΅ Π΄Π»Ρ ΠΈΠ·Π²Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΡΠΆΠ΅Π»ΡΡ ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ² ΠΈΠ· Π²ΠΎΠ΄Π½ΡΡ ΡΡΠ΅Π΄
Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΎΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ½ΡΡ
ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ².Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ Π±ΡΠ» ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ Π½ΠΎΠ²ΡΠΉ ΡΠΎΡΠ±ΡΠΈΠΎΠ½Π½ΡΠΉ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π» Π½Π° ΠΌΠΈΠ½Π΅ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΎΡΠ½ΠΎΠ²Π΅ Π΄Π»Ρ ΠΈΠ·Π²Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΠΈΠΎΠ½ΠΎΠ² ΠΊΠ°Π΄ΠΌΠΈΡ ΠΈ ΡΠ²ΠΈΠ½ΡΠ° ΠΈΠ· Π²ΠΎΠ΄Π½ΡΡ
ΡΠ°ΡΡΠ²ΠΎΡΠΎΠ².In the process of investigation the study of literary sources.In the result there was developed a new sorption material on a mineral basis for izvlecheniya thions of cadmium and lead from aqueous plaster
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