How core stiffness and Poisson ratio affect energy balance roll structure formulas

The stiffness of the core determines how much support it will offer for the initial wraps of web material, and whether this support will be maintained as internal pressures are developed. An expression is developed for calculating the effective modulus of the core for isotropic and anisotropic material. The linear solution is carried further to predict how this core modulus is reflected in local radial hardness of the roll when additional material is wound onto the core. The radial modulus parameters of a roll winding model based upon energy balance are adjusted to account for the stiffening or yielding effect of the core under given winding conditions. The effect of different Poisson ratios on core stiffness and roll formation is discussed

Structural evaluation of roll quality and in-roll stress analysis using a novel on-line measurement technique

In a previous paper (Jaafar et al., 1999) we reported on the rudimentary development of a new technique for the on-line measurement of a roll's coefficient of restitution (Cr) as it is being wound, and enunciated the theoretical underpinnings behind the development. In this paper, the Cr sensor has been used to evaluate the radial and tangential roll behavior as it is being built. Based on the experimental findings, numerical simulations are proposed for modeling, using energy-based formulations, radial modulus and tangential stress as a function of roll radius. The simulations take into account the additive effect of winding operations, and corrects for the use of such idealized set-ups as the stack experiment, first proposed by Pfeiffer (1966), by incorporating increasing number of layers.In addition to basic structural assessment of roll quality in real time, a set of experiments have been devised to garner a fundamental understanding of the in-roll stress variations, based on which new insight into the constitutive relations is presented

Air Bubble Size and Its Transition in a Horizontal Tube Produced by Venturi-Nozzle Bubble Generator

This paper investigates the air bubble size and its transition in a horizontal tube of 700 mm. The tube was assembled with a venturi-nozzle bubble generator. Air and water flow-rates vary in the present study. The data collection mainly used high-speed camera to capture the bubbles at different distances along the horizontal tube at water flow-rates (Qw) of 120-170 litre per min (LPM) and air flow-rates (Qa) of 2-10 LPM. MATLAB was used in image processing for evaluating the bubble size. The data interpretation used YW dimensionless parameter in representing the height of the bubbles’ vertical rise in the horizontal tube. The bubble size along the horizontal tube was characterized by the Weber number as well. The type of two-phase (water-air bubbles) flow along the horizontal tube from the venturi-nozzle bubble generator was determined using flow pattern map and Lockhart-Martinelli parameter. The bubble generator produced bubbles in the range of 0.8-3.1 mm at the inlet of horizontal tube. The bubble diameters increased as the bubbles moved horizontally from inlet to outlet of the horizontal tube and this finding was statistically significant. The vertical rise height of bubbles along the horizontal tube at different water and air flow-rates had been quantified and compared. The vertical rise height of bubbles increased axially from 41 % to 89 % from inlet to outlet of the horizontal tube. The bubbles’ vertical rise height increased when either the air flow-rate or water flow-rate is reduced. The mean Weber number increased along the horizontal tube due to an increase in bubble size. The decrease in water flow-rate caused a decrease in the mean Weber number. The Lockhart-Martinelli parameter of the water-air bubbles flow in the horizontal tube was within 0.58-2.94, indicating that it was a multiphase flow. The findings from this study give fundamental insight into bubble dynamics behaviour in its horizontal transition. This study focuses on the size and transition of air bubbles produced by venturi-nozzle bubble generator along a horizontal tube at different water and air flow-rates, unlike previous studies which only investigate the air bubbles inside or near bubble generator. These findings are very useful for practical industrial applications because the exact air bubble size before being used is known

Quasi-energy-independent solar neutrino transitions

Current solar, atmospheric, and reactor neutrino data still allow oscillation scenarios where the squared mass differences are all close to 10^-3 eV^2, rather than being hierarchically separated. For solar neutrinos, this situation (realized in the upper part of the so-called large-mixing angle solution) implies adiabatic transitions which depend weakly on the neutrino energy and on the matter density, as well as on the ``atmospheric'' squared mass difference. In such a regime of ``quasi-energy-independent'' (QEI) transitions, intermediate between the more familiar ``Mikheyev-Smirnov-Wolfenstein'' (MSW) and energy-independent (EI) regimes, we first perform analytical calculations of the solar nu_e survival probability at first order in the matter density, beyond the usual hierarchical approximations. We then provide accurate, generalized expressions for the solar neutrino mixing angles in matter, which reduce to those valid in the MSW, QEI and EI regimes in appropriate limits. Finally, a representative QEI scenario is discussed in some detail.Comment: Title changed; text and acronyms revised; results unchanged. To appear in PR

Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group.

Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse events (irAEs). Many of these are driven by the same immunologic mechanisms responsible for the drugs\u27 therapeutic effects, namely blockade of inhibitory mechanisms that suppress the immune system and protect body tissues from an unconstrained acute or chronic immune response. Skin, gut, endocrine, lung and musculoskeletal irAEs are relatively common, whereas cardiovascular, hematologic, renal, neurologic and ophthalmologic irAEs occur much less frequently. The majority of irAEs are mild to moderate in severity; however, serious and occasionally life-threatening irAEs are reported in the literature, and treatment-related deaths occur in up to 2% of patients, varying by ICI. Immunotherapy-related irAEs typically have a delayed onset and prolonged duration compared to adverse events from chemotherapy, and effective management depends on early recognition and prompt intervention with immune suppression and/or immunomodulatory strategies. There is an urgent need for multidisciplinary guidance reflecting broad-based perspectives on how to recognize, report and manage organ-specific toxicities until evidence-based data are available to inform clinical decision-making. The Society for Immunotherapy of Cancer (SITC) established a multidisciplinary Toxicity Management Working Group, which met for a full-day workshop to develop recommendations to standardize management of irAEs. Here we present their consensus recommendations on managing toxicities associated with immune checkpoint inhibitor therapy

Bulk properties of the system formed in Au+Au collisions at sNN =14.5 GeV at the BNL STAR detector

We report systematic measurements of bulk properties of the system created in Au+Au collisions at sNN=14.5 GeV recorded by the STAR detector at the Relativistic Heavy Ion Collider (RHIC). The transverse momentum spectra of π±, K±, and p(p) are studied at midrapidity (|y|<0.1) for nine centrality intervals. The centrality, transverse momentum (pT), and pseudorapidity (η) dependence of inclusive charged particle elliptic flow (v2), and rapidity-odd charged particles directed flow (v1) results near midrapidity are also presented. These measurements are compared with the published results from Au+Au collisions at other energies, and from Pb+Pb collisions at sNN=2.76 TeV. The results at sNN=14.5 GeV show similar behavior as established at other energies and fit well in the energy dependence trend. These results are important as the 14.5-GeV energy fills the gap in μB, which is of the order of 100 MeV, between sNN=11.5 and 19.6 GeV. Comparisons of the data with UrQMD and AMPT models show poor agreement in general

Azimuthal anisotropy in U+U and Au+Au collisions at RHIC

Collisions between prolate uranium nuclei are used to study how particle production and azimuthal anisotropies depend on initial geometry in heavy-ion collisions. We report the two- and four-particle cumulants, $v_2\{2\}$ and $v_2\{4\}$, for charged hadrons from U+U collisions at $\sqrt{s_{\rm NN}}$ = 193 GeV and Au+Au collisions at $\sqrt{s_{\rm NN}}$ = 200 GeV. Nearly fully overlapping collisions are selected based on the amount of energy deposited by spectators in the STAR Zero Degree Calorimeters (ZDCs). Within this sample, the observed dependence of $v_2\{2\}$ on multiplicity demonstrates that ZDC information combined with multiplicity can preferentially select different overlap configurations in U+U collisions. An initial-state model with gluon saturation describes the slope of $v_2\{2\}$ as a function of multiplicity in central collisions better than one based on Glauber with a two-component multiplicity model.Comment: Final paper version accepted for publication in Phys. Rev. Lett. New version includes comparisons to a constituent quark glauber mode

Observation of charge asymmetry dependence of pion elliptic flow and the possible chiral magnetic wave in heavy-ion collisions

We present measurements of $\pi^-$ and $\pi^+$ elliptic flow, $v_2$, at midrapidity in Au+Au collisions at $\sqrt{s_{_{\rm NN}}} =$ 200, 62.4, 39, 27, 19.6, 11.5 and 7.7 GeV, as a function of event-by-event charge asymmetry, $A_{ch}$, based on data from the STAR experiment at RHIC. We find that $\pi^-$ ($\pi^+$) elliptic flow linearly increases (decreases) with charge asymmetry for most centrality bins at $\sqrt{s_{_{\rm NN}}} = \text{27 GeV}$ and higher. At $\sqrt{s_{_{\rm NN}}} = \text{200 GeV}$, the slope of the difference of $v_2$ between $\pi^-$ and $\pi^+$ as a function of $A_{ch}$ exhibits a centrality dependence, which is qualitatively similar to calculations that incorporate a chiral magnetic wave effect. Similar centrality dependence is also observed at lower energies.Comment: 6 pages, 4 figure