160 research outputs found
Self-organizing & stochastic behaviors during the regeneration of hair stem cells
Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combining predictive mathematical modeling with in vivo studies in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integration of inputs from intrinsic follicular and extrinsic environmental signals based on universal patterning principles. Signaling from the WNT/bone morphogenetic protein activator/inhibitor pair is coopted to mediate interactions among follicles in the population. This regenerative strategy is robust and versatile because relative activator/inhibitor strengths can be modulated easily, adapting the organism to different physiological and evolutionary needs
Turing learning: : A metric-free approach to inferring behavior and its application to swarms
We propose Turing Learning, a novel system identification method for
inferring the behavior of natural or artificial systems. Turing Learning
simultaneously optimizes two populations of computer programs, one representing
models of the behavior of the system under investigation, and the other
representing classifiers. By observing the behavior of the system as well as
the behaviors produced by the models, two sets of data samples are obtained.
The classifiers are rewarded for discriminating between these two sets, that
is, for correctly categorizing data samples as either genuine or counterfeit.
Conversely, the models are rewarded for 'tricking' the classifiers into
categorizing their data samples as genuine. Unlike other methods for system
identification, Turing Learning does not require predefined metrics to quantify
the difference between the system and its models. We present two case studies
with swarms of simulated robots and prove that the underlying behaviors cannot
be inferred by a metric-based system identification method. By contrast, Turing
Learning infers the behaviors with high accuracy. It also produces a useful
by-product - the classifiers - that can be used to detect abnormal behavior in
the swarm. Moreover, we show that Turing Learning also successfully infers the
behavior of physical robot swarms. The results show that collective behaviors
can be directly inferred from motion trajectories of individuals in the swarm,
which may have significant implications for the study of animal collectives.
Furthermore, Turing Learning could prove useful whenever a behavior is not
easily characterizable using metrics, making it suitable for a wide range of
applications.Comment: camera-ready versio
Risk-Return Relationship in a Complex Adaptive System
For survival and development, autonomous agents in complex adaptive systems involving the human society must compete against or collaborate with others for sharing limited resources or wealth, by using different methods. One method is to invest, in order to obtain payoffs with risk. It is a common belief that investments with a positive risk-return relationship (namely, high risk high return and vice versa) are dominant over those with a negative risk-return relationship (i.e., high risk low return and vice versa) in the human society; the belief has a notable impact on daily investing activities of investors. Here we investigate the risk-return relationship in a model complex adaptive system, in order to study the effect of both market efficiency and closeness that exist in the human society and play an important role in helping to establish traditional finance/economics theories. We conduct a series of computer-aided human experiments, and also perform agent-based simulations and theoretical analysis to confirm the experimental observations and reveal the underlying mechanism. We report that investments with a negative risk-return relationship have dominance over those with a positive risk-return relationship instead in such a complex adaptive systems. We formulate the dynamical process for the system's evolution, which helps to discover the different role of identical and heterogeneous preferences. This work might be valuable not only to complexity science, but also to finance and economics, to management and social science, and to physics
Evolutionary optimisation of neural network models for fish collective behaviours in mixed groups of robots and zebrafish
Animal and robot social interactions are interesting both for ethological
studies and robotics. On the one hand, the robots can be tools and models to
analyse animal collective behaviours, on the other hand, the robots and their
artificial intelligence are directly confronted and compared to the natural
animal collective intelligence. The first step is to design robots and their
behavioural controllers that are capable of socially interact with animals.
Designing such behavioural bio-mimetic controllers remains an important
challenge as they have to reproduce the animal behaviours and have to be
calibrated on experimental data. Most animal collective behavioural models are
designed by modellers based on experimental data. This process is long and
costly because it is difficult to identify the relevant behavioural features
that are then used as a priori knowledge in model building. Here, we want to
model the fish individual and collective behaviours in order to develop robot
controllers. We explore the use of optimised black-box models based on
artificial neural networks (ANN) to model fish behaviours. While the ANN may
not be biomimetic but rather bio-inspired, they can be used to link perception
to motor responses. These models are designed to be implementable as robot
controllers to form mixed-groups of fish and robots, using few a priori
knowledge of the fish behaviours. We present a methodology with multilayer
perceptron or echo state networks that are optimised through evolutionary
algorithms to model accurately the fish individual and collective behaviours in
a bounded rectangular arena. We assess the biomimetism of the generated models
and compare them to the fish experimental behaviours.Comment: 10 pages, 4 figure
Predicting the Distribution of Spiral Waves from Cell Properties in a Developmental-Path Model of Dictyostelium Pattern Formation
The slime mold Dictyostelium discoideum is one of the model systems of biological pattern formation. One of the most successful answers to the challenge of establishing a spiral wave pattern in a colony of homogeneously distributed D. discoideum cells has been the suggestion of a developmental path the cells follow (Lauzeral and coworkers). This is a well-defined change in properties each cell undergoes on a longer time scale than the typical dynamics of the cell. Here we show that this concept leads to an inhomogeneous and systematic spatial distribution of spiral waves, which can be predicted from the distribution of cells on the developmental path. We propose specific experiments for checking whether such systematics are also found in data and thus, indirectly, provide evidence of a developmental path
How to Blend a Robot within a Group of Zebrafish: Achieving Social Acceptance through Real-time Calibration of a Multi-level Behavioural Model
We have previously shown how to socially integrate a fish robot into a group
of zebrafish thanks to biomimetic behavioural models. The models have to be
calibrated on experimental data to present correct behavioural features. This
calibration is essential to enhance the social integration of the robot into
the group. When calibrated, the behavioural model of fish behaviour is
implemented to drive a robot with closed-loop control of social interactions
into a group of zebrafish. This approach can be useful to form mixed-groups,
and study animal individual and collective behaviour by using biomimetic
autonomous robots capable of responding to the animals in long-standing
experiments. Here, we show a methodology for continuous real-time calibration
and refinement of multi-level behavioural model. The real-time calibration, by
an evolutionary algorithm, is based on simulation of the model to correspond to
the observed fish behaviour in real-time. The calibrated model is updated on
the robot and tested during the experiments. This method allows to cope with
changes of dynamics in fish behaviour. Moreover, each fish presents individual
behavioural differences. Thus, each trial is done with naive fish groups that
display behavioural variability. This real-time calibration methodology can
optimise the robot behaviours during the experiments. Our implementation of
this methodology runs on three different computers that perform individual
tracking, data-analysis, multi-objective evolutionary algorithms, simulation of
the fish robot and adaptation of the robot behavioural models, all in
real-time.Comment: 9 pages, 3 figure
Group Living Enhances Individual Resources Discrimination: The Use of Public Information by Cockroaches to Assess Shelter Quality
In group-living organisms, consensual decision of site selection results from the interplay between individual responses to site characteristics and to group-members. Individuals independently gather personal information by exploring their environment. Through social interaction, the presence of others provides public information that could be used by individuals and modulates the individual probability of joining/leaving a site. The way that individual's information processing and the network of interactions influence the dynamics of public information (depending on population size) that in turn affect discrimination in site quality is a central question. Using binary choice between sheltering sites of different quality, we demonstrate that cockroaches in group dramatically outperform the problem-solving ability of single individual. Such use of public information allows animals to discriminate between alternatives whereas isolated individuals are ineffective (i.e. the personal discrimination efficiency is weak). Our theoretical results, obtained from a mathematical model based on behavioral rules derived from experiments, highlight that the collective discrimination emerges from competing amplification processes relying on the modulation of the individual sheltering time without shelters comparison and communication modulation. Finally, we well demonstrated here the adaptive value of such decision algorithm. Without any behavioral change, the system is able to shift to a more effective strategy when alternatives are present: the modification of the spatio-temporal distributions of individuals leading to the collective selection of the best resource. This collective discrimination implying such parsimonious and widespread mechanism must be shared by many group living-species
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