Yttrium Aluminum Garnet Fibers from Metalloorganic Precursors

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65151/1/j.1151-2916.1998.tb02383.x.pd

Development and Validation of Physics Based Models for Ice Shedding

Calculations for ice accretion and shedding are presented for a model scale rotor in hover. The aerodynamic characteristics of the rotor are first computed using a combined blade element-momentum theory. The effective angles of attack, and the local flow velocity are used within the NASA Glenn solver LEWICE to estimate the collection efficiency. The computed convection efficiency and the surface pressure distribution from a panel method within LEWICE are used to estimate the ice accretion over the rotor blades over an elapsed time interval. Finally, a force balance approach is used to establish shedding events where the centrifugal force over the ice mass exceeds the adhesive forces at the rotor surface and the cohesive forces between adjacent masses of ice. Preliminary comparisons with test data acquired at the Pennsylvania State Icing Research Tunnel are presented. Sensitivity of the ice shedding events to surface roughness, adhesive strength, cohesive strength, and ambient conditions is discussed

Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer

OBJECTIVE: Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes.DESIGN: RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers (n=71). Eight working groups (WG) were constituted: discovery science; risk; prevention; early diagnosis and screening; pathology; curative treatment; stage IV disease; and living with and beyond CRC. A series of discussions led to development of draft papers by each WG, which were evaluated by a 20-strong patient panel. A final list of RGs and research recommendations (RR) was endorsed by all participants.RESULTS: Fifteen critical RGs are summarised below: RG1: Lack of realistic models that recapitulate tumour/tumour micro/macroenvironment; RG2: Insufficient evidence on precise contributions of genetic/environmental/lifestyle factors to CRC risk; RG3: Pressing need for prevention trials; RG4: Lack of integration of different prevention approaches; RG5: Lack of optimal strategies for CRC screening; RG6: Lack of effective triage systems for invasive investigations; RG7: Imprecise pathological assessment of CRC; RG8: Lack of qualified personnel in genomics, data sciences and digital pathology; RG9: Inadequate assessment/communication of risk, benefit and uncertainty of treatment choices; RG10: Need for novel technologies/interventions to improve curative outcomes; RG11: Lack of approaches that recognise molecular interplay between metastasising tumours and their microenvironment; RG12: Lack of reliable biomarkers to guide stage IV treatment; RG13: Need to increase understanding of health related quality of life (HRQOL) and promote residual symptom resolution; RG14: Lack of coordination of CRC research/funding; RG15: Lack of effective communication between relevant stakeholders.CONCLUSION: Prioritising research activity and funding could have a significant impact on reducing CRC disease burden over the next 5 years.</p

Impact of general practice endorsement on the social gradient in uptake in bowel cancer screening

This is a summary of independent research funded by the National Institute for Health. Research (NIHR)’s Programme Grants for Applied Research Programme (RP-PG-0609–10106

Fabrication and experimental characterization of d31 telescopic piezoelectric actuators

A popular and useful piezoelectric actuator is the stack. Unfortunately with this type of actuation architecture the long lengths normally required to obtain necessary displacements can pose packaging and buckling problems. To overcome these limitations, a new architecture for piezoelectric actuators has been developed called telescopic. The basic design consists of concentric shells interconnected by end-caps which alternate in placement between the two axial ends of the shells. This leads to a linear displacement amplification at the cost of force; yet the force remains at the same magnitude as a stack and significantly higher than bender type architectures. This paper describes the fabrication and experimental characterization of three different telescopic prototypes. The actuator prototypes discussed in this paper mark a definitive step forward in fabrication techniques for complex piezoceramic structures. Materials Systems, Inc. has adapted injection molding for the fabrication of net shape piezoceramic actuators. Injection molding provides several advantages over conventional fabrication techniques, including: high production rate, uniform part dimensions, uniform piezoelectric properties, and reduced fabrication and assembly costs. Acrylate polymerization, developed at the University of Michigan, is similar to gelcasting, but uses a nonaqueous slurry which facilitates the production of large, tall, complex components such as the telescopic actuator, and is ideal for the rapid manufacture of unique or small batch structures. To demonstrate these fabrication processes a five tube telescopic actuator was injection molded along with a very tall three tube actuator that was cast using the acrylate polymerization method. As a benchmark, a third actuator was built from off-the-shelf tubes that were joined with aluminum end-caps. Each prototype's free deflection behavior was experimentally characterized and the results of the testing are presented within this paper.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44767/1/10853_2004_Article_382116.pd