Local linear spatial quantile regression

Copyright @ 2009 International Statistical Institute / Bernoulli Society for Mathematical Statistics and Probability.Let {(Yi,Xi), i ∈ ZN} be a stationary real-valued (d + 1)-dimensional spatial processes. Denote by x → qp(x), p ∈ (0, 1), x ∈ Rd , the spatial quantile regression function of order p, characterized by P{Yi ≤ qp(x)|Xi = x} = p. Assume that the process has been observed over an N-dimensional rectangular domain of the form In := {i = (i1, . . . , iN) ∈ ZN|1 ≤ ik ≤ nk, k = 1, . . . , N}, with n = (n1, . . . , nN) ∈ ZN. We propose a local linear estimator of qp. That estimator extends to random fields with unspecified and possibly highly complex spatial dependence structure, the quantile regression methods considered in the context of independent samples or time series. Under mild regularity assumptions, we obtain a Bahadur representation for the estimators of qp and its first-order derivatives, from which we establish consistency and asymptotic normality. The spatial process is assumed to satisfy general mixing conditions, generalizing classical time series mixing concepts. The size of the rectangular domain In is allowed to tend to infinity at different rates depending on the direction in ZN (non-isotropic asymptotics). The method provides muchAustralian Research Counci

A note on state-space representations of locally stationary wavelet time series

In this note we show that the locally stationary wavelet process can be decomposed into a sum of signals, each of which follows a moving average process with time-varying parameters. We then show that such moving average processes are equivalent to state space models with stochastic design components. Using a simple simulation step, we propose a heuristic method of estimating the above state space models and then we apply the methodology to foreign exchange rates data

Optical calibration hardware for the Sudbury Neutrino Observatory

The optical properties of the Sudbury Neutrino Observatory (SNO) heavy water Cherenkov neutrino detector are measured in situ using a light diffusing sphere ("laserball"). This diffuser is connected to a pulsed nitrogen/dye laser via specially developed underwater optical fibre umbilical cables. The umbilical cables are designed to have a small bending radius, and can be easily adapted for a variety of calibration sources in SNO. The laserball is remotely manipulated to many positions in the D2O and H2O volumes, where data at six different wavelengths are acquired. These data are analysed to determine the absorption and scattering of light in the heavy water and light water, and the angular dependence of the response of the detector's photomultiplier tubes. This paper gives details of the physical properties, construction, and optical characteristics of the laserball and its associated hardware.Comment: 17 pages, 8 figures, submitted to Nucl. Inst. Meth.

Comment on ``Evidence for Narrow Baryon Resonances in Inelastic pp Scattering''

Compton scattering data are sensitive to the existence of low-mass resonances reported by Tatischeff et al. We show that such states, with their reported properties, are excluded by previous Compton scattering experiments.Comment: One page, submitted to PR

Both apoptosis and necrosis occur early after intracerebral grafting of ventral mesencephalic tissue: a role for protease activation.

Neural transplantation is an experimental treatment for Parkinson's disease. Widespread clinical application of the grafting technique is hampered by a relatively poor survival (around 10%) of implanted embryonic dopamine neurones. Earlier animal studies have indicated that a large proportion of the grafted cells die during graft tissue preparation and within the first few days after intracerebral implantation. The present study was designed to reveal the prevalence of cell death in rat intrastriatal grafts at 90 min, 1, 3, 6 and 42 days after implantation. We examined apoptotic cell death using semi-thin and paraffin sections stained with methylene blue and an antibody against activated caspase 3, respectively. We identified abundant apoptotic cell death up to 3 days after transplantation. In addition, we studied calpain activation using an antibody specific for calpain-cleaved fodrin. We report a peak in calpain activity 90 min after grafting. Surprisingly, we did not observe any significant difference in the number of dopaminergic neurones over time. The present results imply that grafted cells may be victims of either an early necrotic or a later apoptotic cell death and that there is substantial cell death as early as 90 min after implantation

Comparing international coverage of 9/11 : towards an interdisciplinary explanation of the construction of news

This article presents an interdisciplinary model attempting to explain how news is constructed by relying on the contributions of different fields of study: News Sociology, Political Communications, International Communications, International Relations. It is a first step towards developing a holistic theoretical approach to what shapes the news, which bridges current micro to macro approaches. More precisely the model explains news variation across different media organization and countries by focusing on the different way the sense of newsworthiness of journalists is affected by three main variables: national interest, national journalistic culture, and editorial policy of each media organization. The model is developed on the basis of an investigation into what shaped the media coverage of 9/11 in eight elite newspapers across the US, France, Italy and Pakistan

Semiparametrically Efficient Inference Based on Signs and Ranks for Median Restricted Models

Since the pioneering work of Koenker and Bassett (1978), econometric models involving median and quantile rather than the classical mean or conditional mean concepts have attracted much interest.Contrary to the traditional models where the noise is assumed to have mean zero, median-restricted models enjoy a rich group-invariance structure.In this paper, we exploit this invariance structure in order to obtain semiparametrically efficient inference procedures for these models.These procedures are based on residual signs and ranks, and therefore insensitive to possible misspecification of the underlying innovation density, yet semiparametrically efficient at correctly specified densities.This latter combination is a definite advantage of these procedures over classical quasi-likelihood methods.The techniques we propose can be applied, without additional technical difficulties, to both cross-sectional and time-series models.They do not require any explicit tangent space calculation nor any projections on these.

The uses and functions of ageing celebrity war reporters

This article starts from the premise that recognition of professional authority and celebrity status depends on the embodiment and performance of field-specific dispositional practices: there’s no such thing as a natural, though we often talk about journalistic instinct as something someone simply has or doesn’t have. Next, we have little control over how we are perceived by peers and publics, and what we think are active positioning or subjectifying practices are in fact, after Bourdieu, revelations of already-determined delegation. The upshot is that two journalists can arrive at diametrically opposed judgements on the basis of observation of the same actions of a colleague, and as individuals we are blithely hypocritical in forming (or reciting) evaluations of the professional identity of celebrities. Nowhere is this starker than in the discourse of age-appropriate behaviour, which this paper addresses using the examples of ‘star’ war reporters John Simpson, Kate Adie and Martin Bell. A certain rough-around-the-edges irreverence is central to dispositional authenticity amongst war correspondents, and for ageing hacks this incorporates gendered attitudes to sex and alcohol as well as indifference to protocol. And yet perceived age-inappropriate sexual behaviour is also used to undermine professional integrity, and the paper ends by outlining the phenomenological context that makes possible this effortless switching between amoral and moralising recognition by peers and audiences alike

Tax avoidance as an anti-austerity issue: the progress of a protest issue through the public sphere

Theorists of left and right agree that periods of crisis are fertile times at which to precipitate change. However, protesters on the periphery of the public sphere must overcome barriers, or what Habermas called ‘sluice gates’, if their discourse is to be publicly and politically influential. This study of newspaper discourse and activity in parliament and the public sphere over a six year period takes tax justice campaigning in the UK as a case study, and in particular protest group UK Uncut’s attempt to mobilize opposition to austerity by advocating a crackdown on tax avoidance as an alternative to cuts. It finds that whilst UK Uncut successfully amplified existing arguments previously raised by experts, trade unions and the left-leaning press, austerity barely figured in debate about tax avoidance once it was picked up by other actors in the public sphere on the other side of the 'sluice gates'. The reasons for this were structural and discursive, related to the role and interests of receptive actors at the institutional centre of the public sphere, and their ability, along with the conservative press, to transform the moral framing of tax avoidance from the injustice of making the poor pay for the financial crisis through cuts, into the 'unfairness' of middle class earners paying higher taxes than wealthier individuals and corporations. The latter reifies the 'hardworking taxpayer', and implies a more instrumental and clientalistic relationship to the state, and an essentially neoliberal sense of fairness. Where neoliberal ideology was challenged, it was in social conservative terms – nationalist opposition to globalisation, framing multinational corporations as a threat to the domestic high street – rather than protesters’ social democratic challenge to market power and social injustice. This indicates how a progressive message from the periphery can be co-opted into the currently resurgent right-wing populism

Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia.

BackgroundThe CXCR4-CXCL12 axis plays an important role in the chronic lymphocytic leukemia (CLL)-microenvironment interaction. Overexpression of CXCR4 has been reported in different hematological malignancies including CLL. Binding of the pro-survival chemokine CXCL12 with its cognate receptor CXCR4 induces cell migration. CXCL12/CXCR4 signaling axis promotes cell survival and proliferation and may contribute to the tropism of leukemia cells towards lymphoid tissues and bone marrow. Therefore, we hypothesized that targeting CXCR4 with an IgG1 antibody, PF-06747143, may constitute an effective therapeutic approach for CLL.MethodsPatient-derived primary CLL-B cells were assessed for cytotoxicity in an in vitro model of CLL microenvironment. PF-06747143 was analyzed for cell death induction and for its potential to interfere with the chemokine CXCL12-induced mechanisms, including migration and F-actin polymerization. PF-06747143 in vivo efficacy was determined in a CLL murine xenograft tumor model.ResultsPF-06747143, a novel-humanized IgG1 CXCR4 antagonist antibody, induced cell death of patient-derived primary CLL-B cells, in presence or absence of stromal cells. Moreover, cell death induction by the antibody was independent of CLL high-risk prognostic markers. The cell death mechanism was dependent on CXCR4 expression, required antibody bivalency, involved reactive oxygen species production, and did not require caspase activation, all characteristics reminiscent of programmed cell death (PCD). PF-06747143 also induced potent B-CLL cytotoxicity via Fc-driven antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity activity (CDC). PF-06747143 had significant combinatorial effect with standard of care (SOC) agents in B-CLL treatment, including rituximab, fludarabine (F-ara-A), ibrutinib, and bendamustine. In a CLL xenograft model, PF-06747143 decreased tumor burden and improved survival as a monotherapy, and in combination with bendamustine.ConclusionsWe show evidence that PF-06747143 has biological activity in CLL primary cells, supporting a rationale for evaluation of PF-06747143 for the treatment of CLL patients