SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL 5-((1H-INDOL-3-YL) METHYLENE)-2-((4-(3A, 4, 5, 6, 7, 7A-HEXAHYDRO-4, 7-METHANEBENZO[D] ISOOXAZOL-3-YL) PHENYL) IMINO)-3-METHYLTHIAZOLIDIN-4-ONE DERIVATIVES

Abstract-A series of novel 5-((1H-indol-3-yl) methylene)-2- ((4-(3a, 4, 5, 6, 7, 7a-hexahydro-4, 7-methanebenzo[d] isooxazol-3-yl) phenyl) imino)-3-methylthiazolidin-4-one derivatives were synthesized and evaluated for their antibacterial and antifungal activity. The structures of the synthesised compounds were determined by IR, NMR, mass spectroscopy and elemental analysis. They were screened for activities against bacterial and fungal strains. Amongst the synthesised compounds 9b, 9e, 9i, 10g, 10h & 10i were found to be active

Synthesis and Antimicrobial Activity of 3-Cyano-4-imino-9-methoxy-4H-pyrimido [2, 1-b] pyrimido [4, 5-b] quinoline and 2-Substituted Derivatives

The 2-amino-7-methoxypyrimido[4,5-b]quinoline (1) on treatment with bis(methylthio)methylene malononitrile (2) in ethyl alcohol and catalytic amount of TEA gives 3-cyano-4-imino-9-methoxy-2-methythio-4H-pyrimido[2,1-b]pyrimido[4,5-b]quinoline (3). The latter were further reacted with selected N-, O-, and C-nucleophiles such as aryl amines, hetryl amines, substituted phenols, and compounds containing an active methylene group