Abstract-A series of novel 5-((1H-indol-3-yl) methylene)-2- ((4-(3a, 4, 5, 6, 7, 7a-hexahydro-4, 7-methanebenzo[d] isooxazol-3-yl) phenyl) imino)-3-methylthiazolidin-4-one derivatives were synthesized and evaluated for their antibacterial and antifungal activity. The structures of the synthesised compounds were determined by IR, NMR, mass spectroscopy and elemental analysis. They were screened for activities against bacterial and fungal strains. Amongst the synthesised compounds 9b, 9e, 9i, 10g, 10h & 10i were found to be active
