PALEOPRODUCTIVITY VARIATIONS IN THE EASTERN CENTRAL EQUATORIAL PACIFIC OCEAN ON GLACIAL TIMESCALES

Indiana University-Purdue University Indianapolis (IUPUI)Paleoproductivity records during the late Pleistocene are sparse. The equatorial Pacific and the Southern Ocean are collectively responsible for the majority of the new production in the oceans. The nutrient and carbon mass balances of these regions must be constrained in order to fully understand net global biological productivity on glacial timescales. The geochemistry of two east-central equatorial Pacific Ocean cores (02° 33.48 N; 117° 55.06 W) and (00° 15.42 S; 113° 00.57 W) are used to examine changes in biological productivity due to nutrient upwelling on glacial timescales during the Pleistocene. The cores were recovered in March 2006 on the AMAT03 cruise, a site survey cruise for IODP Proposal 626. The total concentrations of Ca, Ti, Fe, Al, P, Ba, S, Mg, Sr, Zn and Mn were determined by a total sediment digestion followed by analysis by inductively coupled plasma-atomic emission spectrometry (ICP). Original solid forms of P for 34 evenly spaced samples throughout one core were determined using the P Sequential Extraction technique. This study is attempting to compare upwelling and productivity records by determining temporal records of nutrient proxies, using Latimer and Filippelli (2006) which focused on the Southern Ocean. Equatorial upwelling and Southern Ocean upwelling both appear to exhibit strong glacial timescale variability. The P geochemistry results indicate that the P signal is largely biological. The equatorial Pacific evidence, in accordance with Southern Ocean patterns, supports a nutrient budget-driven productivity signal over time. Gabriel M. Filippelli, Ph. D, Committee Chai

Analysis of the 1960 and 1961 Oregon State University clothing construction placement test

The analysis of the most recent revision of the Clothing Construction Placement Test battery was undertaken for the purpose of evaluating the worth of the three parts of the test in placing students in the accelerated and regular sections of Clothing Construction, CT 210, and in determining exemptions from the course. A review of literature related to pretesting in clothing construction on the college level was essential to the development of this study. A group of 427 tests administered to incoming students in the fall of 1960 and 1961 determined the basic population for the analysis. Simple correlations were run which showed the test battery measured a factor other than that evaluated by data previously available on the entering students. The examination portion of the test battery gave a reliability coefficient of .641 between the test and retest sample of 104 observations. The reliability of the Miller Survey of Object Visualization, which was the second test in the battery, was not computed for this study. An item analysis of the difficulty and discrimination values of the items for the 427 tests indicated weaknesses within the examination section. The validity coefficient between the total score received on the test battery and the final grade in the course was .424 for 312 observations. Scrutiny of the curricular validity revealed that the test was inadequate in its present form as the only device for determining exemptions from the course. The type of background experience as measured by the data background information sheet did not appear to be significant when correlated with the final grade in the course. This indicated that the sheet could be eliminated from the battery without any adverse effects. The test battery was found to be useful and practical in sectioning students. However, there was a problem of scheduling its administration. According to the results of the questionnaire given to the students at the time of the retest, they were not as well informed as to the purpose of the test and their placement as would have been desired. It was recommended that the use of the test battery be continued after changes are made in the Clothing Construction Placement Examination portion to improve its reliability and validity

‘They think we are delaying their outputs’. The challenges of interdisciplinary research: understanding power dynamics between social and biophysical scientists in international crop breeding teams

Public sector crop improvement for development programmes aims to produce varieties tailored to the needs of smallholder farmers and their environments. Understanding how social heterogeneity, including gender, drives trait preferences is essential to ensure that crop improvement objectives meet farmers’ and stakeholder demands. This requires an interdisciplinary approach, integrating social science knowledge with crop breeding. Although the necessity of interdisciplinary research is recognised and promoted, it is impeded by a multitude of challenges including ontological and epistemological differences, institutional and global hierarchies, disciplinary power relations and struggles for scientific authority. The Agricultural Research for Development (AR4D) sector is marked by entrenched power differentials, including dominance of the biophysical sciences, a historical emphasis on technical solutions which ignores social contexts, and the underrepresentation of women scientists and farmers themselves. Nevertheless, there is limited theoretically informed analysis of power dynamics within AR4D settings. Drawing on qualitative, ethnographic observations of the Feed the Future Innovation Lab for Crop Improvement (ILCI), this article seeks to understand how power affects interdisciplinary research processes. Critical ethnography and power theory is used to analyse power within international crop breeding collaborations and the implications for inclusive knowledge production and research impact. The Powercube is used to examine how visible, hidden and invisible forms of power manifest within local, national, and international relationships across closed, invited and claimed spaces. Our findings suggest that these intersecting power dimensions, which include disciplinary, gendered, institutional and global hierarchies, constrain the contributions that individual researchers can make – particularly social scientists – thereby hindering disciplinary integration. The ILCI case study reveals the complex multi-dimensional dynamics that emerge within agricultural research teams and highlights structural limitations constraining efforts to build socially inclusive and gender-responsive crop improvement programmes. The article contributes to a small but growing literature studying the social construction of agricultural science, and provides insights that can enable interdisciplinary research strategies to more effectively meet the needs of farmers and other stakeholders

To what extent has COVID-19 impacted hard-to-reach energy audiences?

Energy users who don’t participate in efficiency and conservation programmes despite ongoing outreach are often referred to as ‘Hard-to-Reach’ (HTR). These individuals or organisations can include, e.g., low income or vulnerable households; renters; and small businesses. More effectively engaging HTR audiences is key to ensuring everyone benefits equitably from low-carbon energy transitions and related (policy) interventions. This is even more so the case in light of the COVID-19 pandemic, and the ongoing implications for energy use and affordability for the most vulnerable (and newly-vulnerable) members of our society.Within this context, the main purpose of this paper is to explore the extent to which HTR energy audiences have been impacted by COVID-19. Our primary method for this work was a comprehensive, critical literature review and a compilation of official statistics. We also collected survey, interview and focus group data during 2020 COVID-19 pandemic responses in the U.S., UK, NZ and Sweden. The geographical scope is determined by a 3-year project focusing on HTR energy users and implemented in partnership with the User-Centred Energy Systems Technology Collaboration Programme (Users TCP) by the International Energy Agency (IEA). Key findings we highlight and discuss in this paper:● Sweden has taken a different approach to manage COVID-19, yet when it comes to mobility, declines in demand (~25%) have shown relatively similar patterns to countries with stricter measures. ● In the UK, energy debt is growing due to higher domestic consumption arising from lockdown measures and the reduced income of many households. Most households (72%) have increased their energy (monthly gas and electricity bills are up £32) use. In response, 36% are turning thermostats down and 27% limiting lighting.● In the U.S., a survey of 1,000 energy customers found that more than 50% are using more energy, and monitoring their energy use less; 15% reported postponing a utility bill. ● NZ’s model COVID-19 “elimination” response has included housing, financial support, and specific energy payments to date, though unhealthy and unaffordable housing remains a major issue.Whereas the pandemic has exacerbated several elements of the HTR policy discourse (e.g. impacts on vulnerable and/or low-income households), our findings also reveal several opportunities and critical aspects for policy makers, researchers and utilities to identify and engage HTR energy users

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

Perceptual and conceptual processing of visual objects across the adult lifespan

Abstract: Making sense of the external world is vital for multiple domains of cognition, and so it is crucial that object recognition is maintained across the lifespan. We investigated age differences in perceptual and conceptual processing of visual objects in a population-derived sample of 85 healthy adults (24–87 years old) by relating measures of object processing to cognition across the lifespan. Magnetoencephalography (MEG) was recorded during a picture naming task to provide a direct measure of neural activity, that is not confounded by age-related vascular changes. Multiple linear regression was used to estimate neural responsivity for each individual, namely the capacity to represent visual or semantic information relating to the pictures. We find that the capacity to represent semantic information is linked to higher naming accuracy, a measure of task-specific performance. In mature adults, the capacity to represent semantic information also correlated with higher levels of fluid intelligence, reflecting domain-general performance. In contrast, the latency of visual processing did not relate to measures of cognition. These results indicate that neural responsivity measures relate to naming accuracy and fluid intelligence. We propose that maintaining neural responsivity in older age confers benefits in task-related and domain-general cognitive processes, supporting the brain maintenance view of healthy cognitive ageing