Quantum Chaos in Compact Lattice QED

Complete eigenvalue spectra of the staggered Dirac operator in quenched $4d$ compact QED are studied on $8^3 \times 4$ and $8^3 \times 6$ lattices. We investigate the behavior of the nearest-neighbor spacing distribution $P(s)$ as a measure of the fluctuation properties of the eigenvalues in the strong coupling and the Coulomb phase. In both phases we find agreement with the Wigner surmise of the unitary ensemble of random-matrix theory indicating quantum chaos. Combining this with previous results on QCD, we conjecture that quite generally the non-linear couplings of quantum field theories lead to a chaotic behavior of the eigenvalues of the Dirac operator.Comment: 11 pages, 4 figure

Low and high beta band activity in the primary sensorimotor cortex is diminished by ipsilateral subthalamic stimulation in Parkinsonian patients [Abstract]

Objective: We analyzed how change of the low and high beta power in the primary sensorimotor cortex relates to different levels of subthalamic stimulation; we hypothesized that it is a suitable biomarker for a closed-loop system. Background: Beta power in the motor system is shown to indicate the kinetic state in Parkinson’s disease. Method: We recruited 20 Parkinsonian patients. Bradykinesia of the most affected hand was measured first with Kinesia motion sensor system (Great Lakes NeuroTechnologies) in medication withdrawal; and four levels of contralateral stimulation (0: OFF, 1-3: decreasing symptoms to ON state) was individually selected. We performed 64-channel electroencephalography (EEG) measurement during a resting state with the four levels of stimulation settings mentioned above. We stimulated the usually used contacts during the whole study, and the ipsilateral stimulation remained ON and unchanged. The 2 minutes long EEG segments were cleaned from DBS artifacts by in-house algorithms. We performed line-noise removal; eye blinks and muscle artifacts were eliminated using ICA analyses. We calculated spectral power at the low (13-20Hz) and high (21-30Hz) beta frequency bands at the sensorimotor cortical region both sides using a beamformer algorithm called the Dynamic Imaging of Coherent Sources. We used repeated measures ANOVA to compare power values in the different locations and stimulation conditions in the two frequency bands. The Medical Research Council in Hungary provided ethical approval. (080958/2015/OTIG). Results: Resting state low- and high-frequency beta power in the primary sensorimotor cortex gradually decreased with the elevation of the ipsilateral stimulation level. In the continuously stimulated contralateral hemisphere, beta power remained at the baseline level. The beta power values measured in the two hemispheres were significantly different in stimulation levels 0-2 but not in level 3 (p < 0.05) both in the low- and high-frequency bands. Conclusion: The change of beta power in the primary sensorimotor cortex during STN-DBS is strictly ipsilateral, and depends on the level of stimulation. Beta power in the sensorimotor cortex could be a potential biomarker for closed-loop DBS. The support of Medtronic Inc. for this project is gratefully acknowledged

Future aspects of renal transplantation

New and exciting advances in renal transplantation are continuously being made, and the horizons for organ transplantation are bright and open. This article reviews only a few of the newer advances that will allow renal transplantation to become even more widespread and successful. The important and exciting implications for extrarenal organ transplantation are immediately evident. © 1988 Springer-Verlag

Ladder-QCD at finite isospin chemical potential

We use an effective QCD model (ladder-QCD) to explore the phase diagram for chiral symmetry breaking and restoration at finite temperature with different $u,d$ quark chemical potentials. In agreement with a recent investigation based on the Nambu-Jona-Lasinio model, we find that a finite pion condensate shows up for high enough isospin chemical potential $\mu_{I}=(\mu_{u}-\mu_{d})/2$. For small $\mu_{I}$ the phase diagram in the $(\mu_B,T)$ plane shows two first order transition lines and two critical ending points.Comment: Typed in RevTex4, pages 12, figures 2. Two references adde

Chiral thermodynamics of dense hadronic matter

We discuss phases of hot and dense hadronic matter using chiral Lagrangians. A two-flavored parity doublet model constrained by the nuclear matter ground state predicts chiral symmetry restoration. The model thermodynamics is shown within the mean field approximation. A field-theoretical constraint on possible phases from the anomaly matching is also discussed.Comment: 8 pages, 2 figures, to appear in the proceedings of 6th International Workshop on Critical Point and Onset of Deconfinement (CPOD), 23-29 August 2010 at Joint Institute for Nuclear Research, Dubna, Russi

Sleep and epilepsy: A snapshot of knowledge and future research lines

Sleep and epilepsy have a reciprocal relationship, and have been recognized as bedfellows since antiquity. However, research on this topic has made a big step forward only in recent years. In this narrative review we summarize the most stimulating discoveries and insights reached by the “European school.” In particular, different aspects concerning the sleep–epilepsy interactions are analysed: (a) the effects of sleep on epilepsy; (b) the effects of epilepsy on sleep structure; (c) the relationship between epilepsy, sleep and epileptogenesis; (d) the impact of epileptic activity during sleep on cognition; (e) the relationship between epilepsy and the circadian rhythm; (f) the history and features of sleep hypermotor epilepsy and its differential diagnosis; (g) the relationship between epilepsy and sleep disorders

Investigation of the Possible Functions of PACAP in Human Trophoblast Cells

Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous neuropeptide having a widespread distribution both in the nervous system and peripheral organs including the female reproductive system. Both the peptide and its receptors have been shown in the placenta but its role in placental growth, especially its human aspects, remains unknown. The aim of the present study was to investigate the effects of PACAP on invasion, proliferation, cell survival, and angiogenesis of trophoblast cells. Furthermore, cytokine production was investigated in human decidual and peripheral blood mononuclear cells. For in vitro studies, human invasive proliferative extravillous cytotrophoblast (HIPEC) cells and HTR-8/SVneo human trophoblast cells were used. Both cell types were used for testing the effects of PACAP on invasion and cell survival in order to investigate whether the effects of PACAP in trophoblasts depend on the examined cell type. Invasion was studied by standardized invasion assay. PACAP increased proliferation in HIPEC cells, but not in HTR-8 cells. Cell viability was examined using MTT test, WST-1 assay, and annexin V/propidium iodide flow cytometry assay. Survival of HTR-8/SVneo cells was studied under oxidative stress conditions induced by hydrogen peroxide. PACAP as pretreatment, but not as co-treatment, significantly increased the number of surviving HTR-8 cells. Viability of HIPEC cells was investigated using methotrexate (MTX) toxicity, but PACAP1-38 could not counteract its toxic effect. Angiogenic molecules were determined both in the supernatant and the cell lysate by angiogenesis array. In the supernatant, we found that PACAP decreased the secretion of various angiogenic markers, such as angiopoietin, angiogenin, activin, endoglin, ADAMTS-1, and VEGF. For the cytokine assay, human decidual and peripheral blood lymphocytes were separated and treated with PACAP1-38. Th1 and Th2 cytokines were analyzed with CBA assay and the results showed that there were no significant differences in control and PACAP-treated cells. In summary, PACAP seems to play various roles in human trophoblast cells, depending on the cell type and microenvironmental influences

Fermion determinants in matrix models of QCD at nonzero chemical potential

The presence of a chemical potential completely changes the analytical structure of the QCD partition function. In particular, the eigenvalues of the Dirac operator are distributed over a finite area in the complex plane, whereas the zeros of the partition function in the complex mass plane remain on a curve. In this paper we study the effects of the fermion determinant at nonzero chemical potential on the Dirac spectrum by means of the resolvent, G(z), of the QCD Dirac operator. The resolvent is studied both in a one-dimensional U(1) model (Gibbs model) and in a random matrix model with the global symmetries of the QCD partition function. In both cases we find that, if the argument z of the resolvent is not equal to the mass m in the fermion determinant, the resolvent diverges in the thermodynamic limit. However, for z =m the resolvent in both models is well defined. In particular, the nature of the limit $z \rightarrow m$ is illuminated in the Gibbs model. The phase structure of the random matrix model in the complex m and \mu-planes is investigated both by a saddle point approximation and via the distribution of Yang-Lee zeros. Both methods are in complete agreement and lead to a well-defined chiral condensate and quark number density.Comment: 27 pages, 6 figures, Late