113 research outputs found

    Dynamical Tests of a Deep-Learning Weather Prediction Model

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    Global deep-learning weather prediction models have recently been shown to produce forecasts that rival those from physics-based models run at operational centers. It is unclear whether these models have encoded atmospheric dynamics, or simply pattern matching that produces the smallest forecast error. Answering this question is crucial to establishing the utility of these models as tools for basic science. Here we subject one such model, Pangu-weather, to a set of four classical dynamical experiments that do not resemble the model training data. Localized perturbations to the model output and the initial conditions are added to steady time-averaged conditions, to assess the propagation speed and structural evolution of signals away from the local source. Perturbing the model physics by adding a steady tropical heat source results in a classical Matsuno--Gill response near the heating, and planetary waves that radiate into the extratropics. A localized disturbance on the winter-averaged North Pacific jet stream produces realistic extratropical cyclones and fronts, including the spontaneous emergence of polar lows. Perturbing the 500hPa height field alone yields adjustment from a state of rest to one of wind--pressure balance over ~6 hours. Localized subtropical low pressure systems produce Atlantic hurricanes, provided the initial amplitude exceeds about 5 hPa, and setting the initial humidity to zero eliminates hurricane development. We conclude that the model encodes realistic physics in all experiments, and suggest it can be used as a tool for rapidly testing ideas before using expensive physics-based models

    Characteristics and rarity of the strong 1940s westerly wind event over the Amundsen Sea, West Antarctica

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    Glaciers in the Amundsen Sea Embayment of West Antarctica are rapidly retreating and contributing to sea level rise. Ice loss is occurring primarily via exposure to warm ocean water, which varies in response to local wind variability. There is evidence that retreat was initiated in the mid-20th century, but the perturbation that may have triggered retreat remains unknown. A leading hypothesis is that large pressure and wind anomalies in the 1940s drove exceptionally strong oceanic ice-shelf melting. However, the characteristics, drivers, and rarity of the atmospheric event remain poorly constrained. We investigate the 1940s atmospheric event using paleoclimate reconstructions and climate model simulations. The reconstructions show that large westerly wind anomalies occurred from ∼1938–1942, a combined response to the very large El Niño event from 1940–1942 and other variability beginning years earlier. Climate model simulations provide evidence that events of similar magnitude and duration may occur tens to hundreds of times per 10 kyr of internal climate variability (∼0.2 to 2.5 occurrences per century). Our results suggest that the 1940s westerly event is unlikely to have been exceptional enough to be the sole explanation for the initiation of Amundsen Sea glacier retreat. Additional factors are likely needed to explain the onset of retreat in West Antarctica, such as naturally arising variability in ocean conditions prior to the 1940s or anthropogenically driven trends since the 1940s.</p

    Additions to the Last Millennium Reanalysis Multi-Proxy Database

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    Progress in paleoclimatology increasingly occurs via data syntheses. We describe additions to a collection prepared for use in paleoclimate state estimation, specifically the Last Millennium Reanalysis (LMR). The 2290 additional series include 2152 tree ring chronologies and 138 other series. They supplement the collection used previously and together form a database titled LMRdb 1.0.0. The additional data draws from lake core, ice core, coral, speleothem, and tree ring archives, using published data primarily from the NOAA Paleoclimatology archive and a set of tree ring width chronologies standardized from raw International Tree Ring Data Bank ring width series. In contrast to many previous paleo compilations, the data were not selected (screened) on the basis of their environmental correlation, multi-century length, or other attributes. The inclusion of proxies sensitive to moisture and other environmental variables expands their use in data assimilation. A preliminary calibration using linear regression with mean annual temperature reveals characteristics of the proxy series and their relationship to temperature, as well as the noise and error characteristics of the records. The additional records are structured as individual files in the NOAA Paleoclimatology format and archived at NOAA Paleoclimatology (Anderson et al. 2018) and will continue to be improved and expanded as part of the LMR Project. The additions represent a four-fold increase in the number of records available for assimilation, provide expanded geographic coverage, and add additional proxy variables. Applications include data assimilation, proxy system model development, and paleoclimate reconstruction using climate field reconstruction and other methods

    The mass-metallicity relation at z~1-2 and its dependence on star formation rate

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    We present a new measurement of the gas-phase mass-metallicity relation (MZR), and its dependence on star formation rates (SFRs) at 1.3 < z < 2.3. Our sample comprises 1056 galaxies with a mean redshift of z = 1.9, identified from the Hubble Space Telescope Wide Field Camera 3 (WFC3) grism spectroscopy in the Cosmic Assembly Near-Infrared Deep Extragalactic Survey (CANDELS) and the WFC3 Infrared Spectroscopic Parallel Survey (WISP). This sample is four times larger than previous metallicity surveys at z ~ 2, and reaches an order of magnitude lower in stellar mass (10^8 M_sun). Using stacked spectra, we find that the MZR evolves by 0.3 dex relative to z ~ 0.1. Additionally, we identify a subset of 49 galaxies with high signal-to-noise (SNR) spectra and redshifts between 1.3 < z < 1.5, where H-alpha emission is observed along with [OIII] and [OII]. With accurate measurements of SFR in these objects, we confirm the existence of a mass-metallicity-SFR (M-Z-SFR) relation at high redshifts. These galaxies show systematic differences from the local M-Z-SFR relation, which vary depending on the adopted measurement of the local relation. However, it remains difficult to ascertain whether these differences could be due to redshift evolution, as the local M-Z-SFR relation is poorly constrained at the masses and SFRs of our sample. Lastly, we reproduced our sample selection in the IllustrisTNG hydrodynamical simulation, demonstrating that our line flux limit lowers the normalization of the simulated MZR by 0.2 dex. We show that the M-Z-SFR relation in IllustrisTNG has an SFR dependence that is too steep by a factor of around three.Comment: Accepted for publication in ApJ; 41 pages, 20 figure

    Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

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    Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

    Oligodendroglial neoplasms with ganglioglioma-like maturation: a diagnostic pitfall

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    Although oligodendroglial neoplasms are traditionally considered purely glial, increasing evidence suggests that they are capable of neuronal or neurocytic differentiation. Nevertheless, ganglioglioma-like foci (GGLF) have not been previously described. Herein, we report seven examples where the primary differential diagnosis was a ganglioglioma with an oligodendroglial component. These five male and two female patients ranged in age from 29 to 63 (median 44) years at initial presentation and neuroimaging features were those of diffuse gliomas in general. At presentation, the glial component was oligodendroglioma in six and oligoastrocytoma in one; one was low-grade and six were anaplastic. A sharp demarcation from adjacent GGLF was common, although some intermingling was always present. The GGLF included enlarged dysmorphic and occasionally binucleate ganglion cells, Nissl substance, expression of neuronal antigens, GFAP-positive astrocytic elements, and low Ki-67 labeling indices. In contrast to classic ganglioglioma, however, cases lacked eosinophilic granular bodies and CD34-positive tumor cells. Scattered bizarre astrocytes were also common and one case had focal neurocytic differentiation. By FISH analysis, five cases showed 1p/19q codeletion. In the four cases with deletions and ample dysmorphic ganglion cells for analysis, the deletions were found in both components. At last follow-up, two patients suffered recurrences, one developed radiation necrosis mimicking recurrence, and one died of disease 7.5 years after initial surgery. We conclude that GGLF represents yet another form of neuronal differentiation in oligodendroglial neoplasms. Recognition of this pattern will prevent a misdiagnosis of ganglioglioma with its potential for under-treatment

    Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial

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    Background: Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used safely is unclear. We aimed to estimate the relative and absolute effects of antiplatelet therapy on recurrent intracerebral haemorrhage and whether this risk might exceed any reduction of occlusive vascular events. Methods: The REstart or STop Antithrombotics Randomised Trial (RESTART) was a prospective, randomised, open-label, blinded endpoint, parallel-group trial at 122 hospitals in the UK. We recruited adults (≥18 years) who were taking antithrombotic (antiplatelet or anticoagulant) therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage, discontinued antithrombotic therapy, and survived for 24 h. Computerised randomisation incorporating minimisation allocated participants (1:1) to start or avoid antiplatelet therapy. We followed participants for the primary outcome (recurrent symptomatic intracerebral haemorrhage) for up to 5 years. We analysed data from all randomised participants using Cox proportional hazards regression, adjusted for minimisation covariates. This trial is registered with ISRCTN (number ISRCTN71907627). Findings: Between May 22, 2013, and May 31, 2018, 537 participants were recruited a median of 76 days (IQR 29–146) after intracerebral haemorrhage onset: 268 were assigned to start and 269 (one withdrew) to avoid antiplatelet therapy. Participants were followed for a median of 2·0 years (IQR [1·0– 3·0]; completeness 99·3%). 12 (4%) of 268 participants allocated to antiplatelet therapy had recurrence of intracerebral haemorrhage compared with 23 (9%) of 268 participants allocated to avoid antiplatelet therapy (adjusted hazard ratio 0·51 [95% CI 0·25–1·03]; p=0·060). 18 (7%) participants allocated to antiplatelet therapy experienced major haemorrhagic events compared with 25 (9%) participants allocated to avoid antiplatelet therapy (0·71 [0·39–1·30]; p=0·27), and 39 [15%] participants allocated to antiplatelet therapy had major occlusive vascular events compared with 38 [14%] allocated to avoid antiplatelet therapy (1·02 [0·65–1·60]; p=0·92). Interpretation: These results exclude all but a very modest increase in the risk of recurrent intracerebral haemorrhage with antiplatelet therapy for patients on antithrombotic therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage. The risk of recurrent intracerebral haemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention
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