Autodiagram version for Univac 1108

Autodiagram flow chart programming for Univac 110

Total Pelvic Exenteration for Gynecologic Malignancies

Total pelvic exenteration (PE) is a radical operation, involving en bloc resection of pelvic organs, including reproductive structures, bladder, and rectosigmoid. In gynecologic oncology, it is most commonly indicated for the treatment of advanced primary or locally recurrent cancer. Careful patient selection and counseling are of paramount importance when considering someone for PE. Part of the evaluation process includes comprehensive assessment to exclude unresectable or metastatic disease. PE can be curative for carefully selected patients with gynecologic cancers. Major complications can be seen in as many as 50% of patients undergoing PE, underscoring the need to carefully discuss risks and benefits of this procedure with patients considering exenterative surgery

Superpotentials for M-theory on a G_2 holonomy manifold and Triality symmetry

For $M$-theory on the $G_2$ holonomy manifold given by the cone on {\bf S^3}\x {\bf S^3} we consider the superpotential generated by membrane instantons and study its transformations properties, especially under monodromy transformations and triality symmetry. We find that the latter symmetry is, essentially, even a symmetry of the superpotential. As in Seiberg/Witten theory, where a flat bundle given by the periods of an universal elliptic curve over the $u$-plane occurs, here a flat bundle related to the Heisenberg group appears and the relevant universal object over the moduli space is related to hyperbolic geometry.Comment: 58 pages, latex; references adde

Genome sequence of Listeria monocytogenes 2542, a serotype 4b strain from a cheese-related outbreak in Portugal

We report here the draft genome sequence of Listeria monocytogenes 2542, a serotype 4b clinical strain recovered from a placental sample during a cheese-related listeriosis outbreak in Portugal.Work done by T.C. and T.H. was supported by LOEWE Medical RNomics (B3) and theGermanCentre for Infection Research, Justus-Liebig University Giessen. Financial sup-port for R.M. and V.F. was provided by Fundação para a Ciência e a Tecnologia(FCT)through Ph.D. (SFRH/BD/71704/2010) and postdoctoral (SFRH/BPD/72617/2010) fellow-ships, respectively. Open-access publication was cofinanced by the NEWFOOD NORTE-01-0246-FEDER-000043 project supported by the Norte Portugal Regional OperationalProgramme (NORTE 2020), under the Portugal 2020 Partnership Agreement throughthe European Regional Development Fund (ERDF). We also acknowledge the scientificcollaboration under the FCT project UID/Multi/50016/2013

MetricGAN+/- : increasing robustness of noise reduction on unseen data

Training of speech enhancement systems often does not incorporate knowledge of human perception and thus can lead to unnatural sounding results. Incorporating psychoacoustically motivated speech perception metrics as part of model training via a predictor network has recently gained interest. However, the performance of such predictors is limited by the distribution of metric scores that appear in the training data. In this work, we propose MetricGAN+/- (an extension of MetricGAN+, one such metric-motivated system) which introduces an additional network - a "de-generator" which attempts to improve the robustness of the prediction network (and by extension of the generator) by ensuring observation of a wider range of metric scores in training. Experimental results on the VoiceBank-DEMAND dataset show relative improvement in PESQ score of 3.8% (3.05 vs 3.22 PESQ score), as well as better generalisation to unseen noise and speech

Fluorodeoxyglucose positron emission tomography in the evaluation of germ cell tumours at relapse

Differentiation of active disease from fibrosis/mature teratoma in patients with residual masses or identifying of sites of recurrence in patients with raised markers following treatment of their testicular cancer remains a problem.18F-fluorodeoxyglucose positron emission tomography (FDG-PET) has the potential to identify active disease and thereby influence further management in these patients. We performed a retrospective study of the use of FDG-PET in detecting residual/recurrent testicular carcinoma in 55 patients (seventy FDG-PET scans). Forty-seven scans were for the assessment of residual masses (18 had raised markers) and 23 scans were for the investigation of raised markers in the presence of normal CT scans. True positive results were based on positive histology or clinical follow-up. FDG-PET had a positive predictive value (PPV) of 96% and a negative predictive value (NPV) of 90% in patients with residual masses. This PPV was equivalent to that of markers (94%) but FDG-PET had the advantage of identifying the site of that recurrence. The NPV was higher than that of markers. In patients with raised markers alone the PPV of FDG-PET was 92% but the NPV was only 50%. However, subsequent FDG-PET imaging was frequently the first imaging modality to identify the site of disease. FDG-PET effected a management change in 57% of cases. FDG-PET scanning detected viable tumour in residual masses and identified sites of disease in suspected recurrence. © 2000 Cancer Research Campaig