3,729 research outputs found

    Can high-frequency ultrasound predict metastatic lymph nodes in patients with invasive breast cancer?

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    Aim To determine whether high-frequency ultrasound can predict the presence of metastatic axillary lymph nodes, with a high specificity and positive predictive value, in patients with invasive breast cancer. The clinical aim is to identify patients with axillary disease requiring surgery who would not normally, on clinical grounds, have an axillary dissection, so potentially improving outcome and survival rates. Materials and methods The ipsilateral and contralateral axillae of 42 consecutive patients with invasive breast cancer were scanned prior to treatment using a B-mode frequency of 13 MHz and a Power Doppler frequency of 7 MHz. The presence or absence of an echogenic centre for each lymph node detected was recorded, and measurements were also taken to determine the L/S ratio and the widest and narrowest part of the cortex. Power Doppler was also used to determine vascularity. The contralateral axilla was used as a control for each patient. Results In this study of patients with invasive breast cancer, ipsilateral lymph nodes with a cortical bulge ≥3 mm and/or at least two lymph nodes with absent echogenic centres indicated the presence of metastatic axillary lymph nodes (10 patients). The sensitivity and specificity were 52.6% and 100%, respectively, positive and negative predictive values were 100% and 71.9%, respectively, the P value was 0.001 and the Kappa score was 0.55.\ud Conclusion This would indicate that high-frequency ultrasound can be used to accurately predict metastatic lymph nodes in a proportion of patients with invasive breast cancer, which may alter patient management

    The electromagnetic environment in CFC structures

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    Extensive measurements of induced voltages and currents were made using a CFC (carbon fiber composites) horizontal stabilizer from the A320 as a test bed. The work was done to investigate the efficacy of various protection schemes to reduce the magnitudes of the induced voltages and validate a computer program INDCAL. Results indicate that a good understanding of the various induced voltage mechanisms including the long wave effect due to current redistribution was obtained

    The SMC X-ray transient XTE J0111.2-7317 : a Be/X-ray binary in a SNR?

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    We report observations which confirm the identity of the optical/IR counterpart to the Rossi X-ray Timing Explorer transient source XTE J0111.2-7317. The counterpart is suggested to be a B0-B2 star (luminosity class III--V) showing an IR excess and strong Balmer emission lines. The distance derived from reddening and systemic velocity measurements puts the source in the SMC. Unusually, the source exhibits an extended asymetric H alpha structure.Comment: 5 pages, 3 figs, accepted by MNRA

    Solar Irradiance Variability and Climate

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    The brightness of the Sun varies on all time scales on which it has been observed, and there is increasing evidence that it has an influence on climate. The amplitudes of such variations depend on the wavelength and possibly on the time scale. Although many aspects of this variability are well established, the exact magnitude of secular variations (going beyond a solar cycle) and the spectral dependence of variations are under discussion. The main drivers of solar variability are thought to be magnetic features at the solar surface. The climate reponse can be, on a global scale, largely accounted for by simple energetic considerations, but understanding the regional climate effects is more difficult. Promising mechanisms for such a driving have been identified, including through the influence of UV irradiance on the stratosphere and dynamical coupling to the surface. Here we provide an overview of the current state of our knowledge, as well as of the main open questions

    Researching "Construction client and innovation": Pilot study and analysis

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    Clients or users of products, processes or services are being identified as the potential sources of innovation in research conducted in various sectors (e.g. IT, aviation, and laboratory equipment). At present there is concern about the construction client’s potential to be an innovation promoter within the construction industry. Several researchers have recommended proactive client involvement in construction. Within this background, the authors have designed a research with the aim of ‘improving the role of the client in promoting innovation’. In this context, this paper is an attempt to elaborate on the initial findings that emerged from the initial pilot case stud

    The plastic limit of clays

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    The plastic limit of soils was first described by Atterberg in 1911. The thread-rolling test was standardised at the US Public Roads Bureau in the 1920s and 1930s, and has subsequently become one of the standard tests of soil mechanics. This paper reviews the original definitions of plastic limit as proposed by Atterberg, and proposes that the brittle failure observed in the plastic limit test is caused by either air entry or cavitation in the clay. Critical state soil mechanics is used to show that the observed range of undrained shear strengths of soils at plastic limit is consistent with this hypothesis. The fallacy that strength at plastic limit is a constant is highlighted, and the implications for geotechnical practice are discussed. </jats:p

    Researching construction client and innovation: methodological perspective

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    It is generally accepted that innovation is the implementation of significantly new processes, products or management approaches in order to increase efficiency. Clients or users of products, processes or services are being identified as potential sources of innovation in research conducted in various sectors (e.g. IT, aviation, and laboratory equipment). At present there is concern regarding the construction clients’ potential to be an innovation promoter within the construction industry. Several researchers have recommended proactive client involvement in construction. Within this background, authors have designed a research methodology with the aim of ‘Improvement of the role of the clients in promoting innovation’. In this context, this paper is an attempt to elaborate the philosophical stances taken and methodologies adopted to fulfill these aims
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