258 research outputs found
A Genome-Wide Analysis of Promoter-Mediated Phenotypic Noise in Escherichia coli
Gene expression is subject to random perturbations that lead to fluctuations in the rate of protein production. As a consequence, for any given protein, genetically identical organisms living in a constant environment will contain different amounts of that particular protein, resulting in different phenotypes. This phenomenon is known as “phenotypic noise.” In bacterial systems, previous studies have shown that, for specific genes, both transcriptional and translational processes affect phenotypic noise. Here, we focus on how the promoter regions of genes affect noise and ask whether levels of promoter-mediated noise are correlated with genes' functional attributes, using data for over 60% of all promoters in Escherichia coli. We find that essential genes and genes with a high degree of evolutionary conservation have promoters that confer low levels of noise. We also find that the level of noise cannot be attributed to the evolutionary time that different genes have spent in the genome of E. coli. In contrast to previous results in eukaryotes, we find no association between promoter-mediated noise and gene expression plasticity. These results are consistent with the hypothesis that, in bacteria, natural selection can act to reduce gene expression noise and that some of this noise is controlled through the sequence of the promoter region alon
Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow
At present, it is not clear how memory B lymphocytes are maintained over time, and whether only as circulating cells or also residing in particular tissues. Here we describe distinct populations of isotype-switched memory B lymphocytes (Bsm) of murine spleen and bone marrow, identified according to individual transcriptional signature and B cell receptor repertoire. A population of marginal zone-like cells is located exclusively in the spleen, while a population of quiescent Bsm is found only in the bone marrow. Three further resident populations, present in spleen and bone marrow, represent transitional and follicular B cells and B1 cells, respectively. A population representing 10-20% of spleen and bone marrow memory B cells is the only one qualifying as circulating. In the bone marrow, all cells individually dock onto VCAM1+ stromal cells and, reminiscent of resident memory T and plasma cells, are void of activation, proliferation and mobility
Image-guided ToF depth upsampling: a survey
Recently, there has been remarkable growth of interest in the development and applications of time-of-flight (ToF) depth cameras. Despite the permanent improvement of their characteristics, the practical applicability of ToF cameras is still limited by low resolution and quality of depth measurements. This has motivated many researchers to combine ToF cameras with other sensors in order to enhance and upsample depth images. In this paper, we review the approaches that couple ToF depth images with high-resolution optical images. Other classes of upsampling methods are also briefly discussed. Finally, we provide an overview of performance evaluation tests presented in the related studies
Spin alignment and violation of the OZI rule in exclusive and production in pp collisions
Exclusive production of the isoscalar vector mesons and is
measured with a 190 GeV proton beam impinging on a liquid hydrogen target.
Cross section ratios are determined in three intervals of the Feynman variable
of the fast proton. A significant violation of the OZI rule is found,
confirming earlier findings. Its kinematic dependence on and on the
invariant mass of the system formed by fast proton
and vector meson is discussed in terms of diffractive
production of resonances in competition with central
production. The measurement of the spin density matrix element of
the vector mesons in different selected reference frames provides another
handle to distinguish the contributions of these two major reaction types.
Again, dependences of the alignment on and on are
found. Most of the observations can be traced back to the existence of several
excited baryon states contributing to production which are absent in
the case of the meson. Removing the low-mass resonant
region, the OZI rule is found to be violated by a factor of eight,
independently of .Comment: 23 pages, 13 figures and 5 table
Multiplicities of charged pions and unidentified charged hadrons from deep-inelastic scattering of muons off an isoscalar target
Multiplicities of charged pions and unidentified hadrons produced in
deep-inelastic scattering were measured in bins of the Bjorken scaling variable
, the relative virtual-photon energy and the relative hadron energy .
Data were obtained by the COMPASS Collaboration using a 160 GeV muon beam and
an isoscalar target (LiD). They cover the kinematic domain in the photon
virtuality > 1(GeV/c, , and . In addition, a leading-order pQCD analysis was performed using the
pion multiplicity results to extract quark fragmentation functions
Non‐destructive automatic leaf area measurements by combining stereo and time‐of‐flight images
Leaf area measurements are commonly obtained by destructive and laborious practice. This study shows how stereo and time‐of‐flight (ToF) images can be combined for non‐destructive automatic leaf area measurements. The authors focus on some challenging plant images captured in a greenhouse environment, and show that even the state‐of‐the‐art stereo methods produce unsatisfactory results. By transforming depth information in a ToF image to a localised search range for dense stereo, a global optimisation strategy is adopted for producing smooth results that preserve discontinuity. They also use edges of colour and disparity images for automatic leaf detection and develop a smoothing method necessary for accurately estimating surface area. In addition to show that combining stereo and ToF images gives superior qualitative and quantitative results, 149 automatic measurements on leaf area using the authors system in a validation trial have a correlation of 0.97 with true values and the root‐mean‐square error is 10.97 cm2, which is 9.3% of the average leaf area. Their approach could potentially be applied for combining other modalities of images with large difference in image resolutions and camera positions
Longitudinal double spin asymmetries in single hadron quasi-real photoproduction at high
We measured the longitudinal double spin asymmetries for single
hadron muo-production off protons and deuterons at photon virtuality <
1(GeV/) for transverse hadron momenta in the range 0.7
GeV/ to 4 GeV/ . They were determined using COMPASS data taken
with a polarised muon beam of 160 GeV/ or 200 GeV/ impinging on
polarised or targets. The experimental
asymmetries are compared to next-to-leading order pQCD calculations, and are
sensitive to the gluon polarisation inside the nucleon in the range
of the nucleon momentum fraction carried by gluons
Interplay among transversity induced asymmetries in hadron leptoproduction
In the fragmentation of a transversely polarized quark several left-right
asymmetries are possible for the hadrons in the jet. When only one unpolarized
hadron is selected, it exhibits an azimuthal modulation known as Collins
effect. When a pair of oppositely charged hadrons is observed, three
asymmetries can be considered, a di-hadron asymmetry and two single hadron
asymmetries. In lepton deep inelastic scattering on transversely polarized
nucleons all these asymmetries are coupled with the transversity distribution.
From the high statistics COMPASS data on oppositely charged hadron-pair
production we have investigated for the first time the dependence of these
three asymmetries on the difference of the azimuthal angles of the two hadrons.
The similarity of transversity induced single and di-hadron asymmetries is
discussed. A new analysis of the data allows to establish quantitative
relationships among them, providing for the first time strong experimental
indication that the underlying fragmentation mechanisms are all driven by a
common physical process.Comment: 6 figure
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