FLASH: Faint Lenses from Associated Selection with Herschel

We report the ALMA Band 7 observations of 86 Herschel sources that likely contain gravitationally-lensed galaxies. These sources are selected with relatively faint 500 $\mu$m flux densities between 15 to 85 mJy in an effort to characterize the effect of lensing across the entire million-source Herschel catalogue. These lensed candidates were identified by their close proximity to bright galaxies in the near-infrared VISTA Kilo-Degree Infrared Galaxy Survey (VIKING) survey. Our high-resolution observations (0.15 arcsec) confirm 47 per cent of the initial candidates as gravitational lenses, while lensing cannot be excluded across the remaining sample. We find average lensing masses (log M/M$_{\odot}$ = 12.9 $\pm$ 0.5) in line with previous experiments, although direct observations might struggle to identify the most massive foreground lenses across the remaining 53 per cent of the sample, particularly for lenses with larger Einstein radii. Our observations confirm previous indications that more lenses exist at low flux densities than expected from strong galaxy-galaxy lensing models alone, where the excess is likely due to additional contributions of cluster lenses and weak lensing. If we apply our method across the total 660 sqr. deg. H-ATLAS field, it would allow us to robustly identify 3000 gravitational lenses across the 660 square degree Herschel ATLAS fields.Comment: Accepted for publication in MNRAS. Comments and discussion are welcom

Accurate dust temperature determination in a z = 7.13 galaxy

We report ALMA Band 9 continuum observations of the normal, dusty star-forming galaxy A1689-zD1 at z = 7.13, resulting in a ∼4.6 σ detection at 702 GHz. For the first time, these observations probe the far-infrared spectrum shortward of the emission peak of a galaxy in the Epoch of Reionization (EoR). Together with ancillary data from earlier works, we derive the dust temperature, Td, and mass, Md, of A1689-zD1 using both traditional modified blackbody spectral energy density fitting, and a new method that relies only on the [C ii] 158 μm line and underlying continuum data. The two methods give Td = (42+13-7, 40+13-) K, and Md} = (1.7+1.3-0.7, 2.0+1.8-1.0), 7, 107, M⊙. Band 9 observations improve the accuracy of the dust temperature (mass) estimate by ∼50 per cent (6 times). The derived temperatures confirm the reported increasing Td-redshift trend between z = 0 and 8; the dust mass is consistent with a supernova origin. Although A1689-zD1 is a normal UV-selected galaxy, our results, implying that ∼85 per cent of its star-formation rate is obscured, underline the non-negligible effects of dust in EoR galaxies

FLASH: Faint lenses from Associated Selection with <i>Herschel</i>

We report the ALMA Band 7 observations of 86 Herschel sources that likely contain gravitationally-lensed galaxies. These sources are selected with relatively faint 500 μm flux densities between 15 to 85 mJy in an effort to characterize the effect of lensing across the entire million-source Herschel catalogue. These lensed candidates were identified by their close proximity to bright galaxies in the near-infrared VISTA Kilo-Degree Infrared Galaxy Survey (VIKING) survey. Our high-resolution observations (0.15 arcsec) confirm 47 per cent of the initial candidates as gravitational lenses, while lensing cannot be excluded across the remaining sample. We find average lensing masses (log M/M⊙ = 12.9 ± 0.5) in line with previous experiments, although direct observations might struggle to identify the most massive foreground lenses across the remaining 53 per cent of the sample, particularly for lenses with larger Einstein radii. Our observations confirm previous indications that more lenses exist at low flux densities than expected from strong galaxy-galaxy lensing models alone, where the excess is likely due to additional contributions of cluster lenses and weak lensing. If we apply our method across the total 660 sqr. deg. H-ATLAS field, it would allow us to robustly identify 3000 gravitational lenses across the 660 square degree Herschel ATLAS fields

Detections of [C II] 158 μ\mum and [O III] 88 μ\mum in a Local Lyman Continuum Emitter, Mrk 54, and its Implications to High-redshift ALMA Studies

We present integral field, far-infrared (FIR) spectroscopy of Mrk 54, a local Lyman Continuum Emitter (LCE), obtained with FIFI-LS on the Stratospheric Observatory for Infrared Astronomy. This is only the second time, after Haro 11, that [C II] 158 $\mu$m and [O III] 88 $\mu$m spectroscopy of the known LCEs have been obtained. We find that Mrk 54 has a strong [C II] emission that accounts for $\sim1$% of the total FIR luminosity, whereas it has only moderate [O III] emission, resulting in the low [O III]/[C II] luminosity ratio of $0.22\pm0.06$. In order to investigate whether [O III]/[C II] is a useful tracer of $f_{\rm esc}$ (LyC escape fraction), we examine the correlations of [O III]/[C II] and (i) the optical line ratio of $\rm O_{32} \equiv$ [O III] 5007 \AA/[O II] 3727 \AA, (ii) specific star formation rate, (iii) [O III] 88 $\mu$m/[O I] 63 $\mu$m ratio, (iv) gas phase metallicity, and (v) dust temperature based on a combined sample of Mrk 54 and the literature data from the Herschel Dwarf Galaxy Survey and the LITTLE THINGS Survey. We find that galaxies with high [O III]/[C II] luminosity ratios could be the result of high ionization (traced by $\rm O_{32}$), bursty star formation, high ionized-to-neutral gas volume filling factors (traced by [O III] 88 $\mu$m/[O I] 63 $\mu$m), and low gas-phase metallicities, which is in agreement with theoretical predictions. We present an empirical relation between the [O III]/[C II] ratio and $f_{\rm esc}$ based on the combination of the [O III]/[C II] and $\rm O_{32}$ correlation, and the known relation between $\rm O_{32}$ and $f_{\rm esc}$. The relation implies that high-redshift galaxies with high [O III]/[C II] ratios revealed by ALMA may have $f_{\rm esc}\gtrsim0.1$, significantly contributing to the cosmic reionization.Comment: 14 pages, 5 figures, Accepted for publication in Ap

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Total Synthesis of Fusaramin, Enabling Stereochemical Elucidation, Structure–Activity Relationship, and Uncovering the Hidden Antimicrobial Activity against Plant Pathogenic Fungi

Fusaramin (1) was isolated as a mitochondrial inhibitor. However, the fungal producer stops producing 1, which necessitates us to supply 1 by total synthesis. We proposed the complete stereochemical structure based on the biosynthetic pathway of sambutoxin. We have established concise and robust total synthesis of 1, enabling us to determine the complete stereochemical structure and to elucidate the structure–activity relationship, and uncover the hidden antiplant pathogenic fungal activity

The 300 pc Resolution Imaging of a z = 8.31 Galaxy: Turbulent Ionized Gas and Potential Stellar Feedback 600 Million Years after the Big Bang

We present the results of 300 pc resolution Atacama Large Millimeter/submillimeter Array imaging of the [O iii ] 88 μm line and dust continuum emission from a z = 8.312 Lyman-break galaxy MACS0416_Y1. The velocity-integrated [O iii ] emission has three peaks that are likely associated with three young stellar clumps of MACS0416_Y1, while the channel map shows a complicated velocity structure with little indication of a global velocity gradient unlike what was found in [C ii ] 158 μm at a larger scale, suggesting random bulk motion of ionized gas clouds inside the galaxy. In contrast, dust emission appears as two individual clumps apparently separating or bridging the [O iii ]/stellar clumps. The cross-correlation coefficient between dust and ultraviolet-related emission (i.e., [O iii ] and ultraviolet continuum) is unity on a galactic scale, while it drops at <1 kpc, suggesting well-mixed geometry of multiphase interstellar media on subkiloparsec scales. If the cutoff scale characterizes different stages of star formation, the cutoff scale can be explained by gravitational instability of turbulent gas. We also report on a kiloparsec-scale off-center cavity embedded in the dust continuum image. This could be a superbubble producing galactic-scale outflows, since the energy injection from the 4 Myr starburst suggested by a spectral energy distribution analysis is large enough to push the surrounding media creating a kiloparsec-scale cavity