Učinci suplementacije omega 3 masnim kiselinama na razinu oksidativnih markera u krvi, mišićno oštećenje i upalne biljege nakon treninga s opterećenjem u mladih sportaša

The present study was conducted to assess the effect of dietary omega-3 fatty acid supplementation on the levels of oxidative stress, muscle damage, and inflammatory markers after acute resistance exercise in young athletes. In a randomized double-blind design, twenty subjects were divided into two equal groups; each subject receiving three capsules per day (3000 mg) of either omega-3 or a placebo for seven days. All subjects underwent high intensity acute resistance exercise. Venous blood samples were collected one week prior to the exercise, immediately pre-exercise, and 24 hours post exercise. Malondiadehyde (MDA), plasma total antioxidant capacity (FRAP), C-reactive protein (CRP), creatine kinase (CK), and lactate dehydrogenase (LDH) were measured in the serum. MDA, CRP and CK concentrations were significantly higher 24 hours post exercise in the placebo versus the omega-3 group (p=.005). The mean of total antioxidant capacity in both groups showed no significant differences immediately pre-exercise and 24 hours post exercise (p>.005). LDH activity was significantly higher 24 hours post exercise in both groups (p=0,005). Aktivnost LDH bila je statistički značajno viša 24 sata nakon vježbanja u obje grupe (p<0,05). Rezultati ovog istraživanja pokazuju da visokointenzivne vježbe s opterećenjem izazivaju oksidativni stres, sistemske upalne procese i povećavaju razinu pokazatelja staničnih oštećenja u sportaša. Ipak, sedam dana suplementacije omega 3 masnim kiselinama mogu smanjiti navedene učinke treninga

COVID-19 in Africa: care and protection for frontline healthcare workers

Medical staff caring for COVID-19 patients face mental stress, physical exhaustion, separation from families, stigma, and the pain of losing patients and colleagues. Many of them have acquired SARS-CoV-2 and some have died. In Africa, where the pandemic is escalating, there are major gaps in response capacity, especially in human resources and protective equipment. We examine these challenges and propose interventions to protect healthcare workers on the continent, drawing on articles identified on Medline (Pubmed) in a search on 24 March 2020. Global jostling means that supplies of personal protective equipment are limited in Africa. Even low-cost interventions such as facemasks for patients with a cough and water supplies for handwashing may be challenging, as is ‘physical distancing’ in overcrowded primary health care clinics. Without adequate protection, COVID-19 mortality may be high among healthcare workers and their family in Africa given limited critical care beds and difficulties in transporting ill healthcare workers from rural to urban care centres. Much can be done to protect healthcare workers, however. The continent has learnt invaluable lessons from Ebola and HIV control. HIV counselors and community healthcare workers are key resources, and could promote social distancing and related interventions, dispel myths, support healthcare workers, perform symptom screening and trace contacts. Staff motivation and retention may be enhanced through carefully managed risk ‘allowances’ or compensation. International support with personnel and protective equipment, especially from China, could turn the pandemic’s trajectory in Africa around. Telemedicine holds promise as it rationalises human resources and reduces patient contact and thus infection risks. Importantly, healthcare workers, using their authoritative voice, can promote effective COVID-19 policies and prioritization of their safety. Prioritizing healthcare workers for SARS-CoV-2 testing, hospital beds and targeted research, as well as ensuring that public figures and the population acknowledge the commitment of healthcare workers may help to maintain morale. Clearly there are multiple ways that international support and national commitment could help safeguard healthcare workers in Africa, essential for limiting the pandemic’s potentially devastating heath, socio-economic and security impacts on the continen

Long-Term Adaptation of Physical Activity Behavior to Exercise Programs in Type 2 Diabetes

Background: Power training has never been investigated in type 2 diabetes (T2D) to improve physical activity (PA). Methods: The GREAT2DO study was a 12-month RCT of power training (PRT; 3/wk) vs. sham exercise in 103 participants with T2D with 5 yrs follow-up during which both groups were supported to continue PRT. Habitual, intervention and Total PA were obtained by questionnaire/training logs, and HOMA2-IR and HbA1c assessed metabolic profile. Regional and whole body composition were measured with CT scan and bioelectrical impedance. Results: Intervention and Total PA increased significantly during RCT in PRT vs. sham group (p=0.0001), but habitual PA did not (p=0.74). Total PA decreased significantly in the cohort during follow-up (p=0.0001), driven by significantly greater declines in the PRT group (p=0.0001) between 12 and 24 months, then stabilised for 4 yrs. Notably, 43% of those assessed reported engagement in PRT at 72 months, regardless of original randomisation. Improved muscle quality was directly related to Total PA (p=0.04), and increased thigh muscle area and reduced adiposity were directly related to intervention PA (p=0.01-0.04) during RCT. Metabolic profile did not change differentially between groups, with a small improvement in HbA1c in the overall cohort during follow-up (p=0.04). Conclusion: Habitual PA was maintained at baseline across 12 months of power or sham training. However, PRT group did have higher intervention and Total PA vs. sham group, linked to adaptations in adiposity and muscle area. PRT group did not maintain higher PA levels over 5 yrs follow-up, as both groups decreased structured exercise once supervision was withdrawn. Sustained improvements in PA behavior in clinical cohorts requires continuous behavioral change interventions if robust anabolic exercise engagement is a key target

Antioxidant enzymes and oxidative stress adaptation to exercise training: Comparison of endurance, resistance, and concurrent training in untrained males

The aim of this study was to compare the effect of endurance training (ET), resistance training (RT), and concurrent training (CT) on circulating antioxidant capacity and oxidative stress. For this purpose, 30 men aged 21.7 ± 2.4 years were assigned to the following three training groups: ET, which included continuous running with incremental intensity that was increased up to 80% of maximal heart rate (n = 10); RT, which included a beginning load of 50% of one repetition maximum (1RM) that was increased up to 80% of 1RM (n = 10); and CT, which included ET and RT programs every other day during the week (n = 10). Activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in erythrocytes and total antioxidant capacity (TAC) and malondialdehyde (MDA) level in plasma were measured. The results showed that SOD significantly increased by 21.85% (p = 0.020), 9.54% (p = 0.032), and 14.55% (p = 0.038) in the ET, RT, and CT groups, respectively. Furthermore, the activity of erythrocyte GPx significantly increased in the ET (p = 0.018) and CT (p = 0.042) groups. The TAC increased significantly in the ET (p = 0.040) and CT (p = 0.049) groups compared with the pretest values. The MDA level significantly decreased in the ET group by 32.7% (p = 0.028), by 32% in the RT group (p = 0.025), and by 29.1% (p = 0.047) in the CT group. However, there was no significant difference in the interaction of time and group between variables of SOD and GPx enzymes and TAC of plasma and MDA in the ET, RT, and CT groups (p < 0.05). It can be concluded that all three training types induced the same changes in redox state (increased SOD activity and reduction in MDA levels), but at different rates

Effects of Three Different Modes of Resistance Training on Appetite Hormones in Males With Obesity

Purpose: This study explored the effect of three different modes of resistance training on appetite hormones [leptin, ghrelin, cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), and peptide tyrosine–tyrosine (PYY)], cardiometabolic and anthropometric measures in males with obesity. Methods: Forty-four males with obesity (age: 27.5 ± 9.4 yrs.; mean weight: 93.2 ± 2.2 kg, body mass index: 32.9 ± 1.2 kg/m2) were randomized to traditional resistance training (TRT, n = 11), circuit resistance training (CRT, n = 11), interval resistance training (IRT, n = 11) or control (C, n = 11) groups. All resistance training groups received 50 min of supervised training per session, three days per week, for 12 weeks. Measurements were taken at baseline and after 12 weeks of training. Results: Plasma levels of leptin, ghrelin, CCK, and PYY decreased significantly in all three different modalities of resistance training groups when compared to the control group (p \u3c 0.05). GLP-1 increased significantly in both CRT and IRT groups compared to TRT and C groups (p \u3c 0.05). Glucose-dependent insulinotropic polypeptide decreased significantly in CRT and IRT groups compared to the C group (p \u3c 0.05). Adiponectin levels increased significantly in all resistance training groups compared to the C group (p \u3c 0.05). Conclusion: Overall, CRT and IRT protocols had the greatest impact on appetite hormones compared to individuals who engaged in TRT or did not exercise (C)

Učinci suplementacije omega 3 masnim kiselinama na razinu oksidativnih markera u krvi, mišićno oštećenje i upalne biljege nakon treninga s opterećenjem u mladih sportaša

The present study was conducted to assess the effect of dietary omega-3 fatty acid supplementation on the levels of oxidative stress, muscle damage, and inflammatory markers after acute resistance exercise in young athletes. In a randomized double-blind design, twenty subjects were divided into two equal groups; each subject receiving three capsules per day (3000 mg) of either omega-3 or a placebo for seven days. All subjects underwent high intensity acute resistance exercise. Venous blood samples were collected one week prior to the exercise, immediately pre-exercise, and 24 hours post exercise. Malondiadehyde (MDA), plasma total antioxidant capacity (FRAP), C-reactive protein (CRP), creatine kinase (CK), and lactate dehydrogenase (LDH) were measured in the serum. MDA, CRP and CK concentrations were significantly higher 24 hours post exercise in the placebo versus the omega-3 group (p=.005). The mean of total antioxidant capacity in both groups showed no significant differences immediately pre-exercise and 24 hours post exercise (p>.005). LDH activity was significantly higher 24 hours post exercise in both groups (p=0,005). Aktivnost LDH bila je statistički značajno viša 24 sata nakon vježbanja u obje grupe (p<0,05). Rezultati ovog istraživanja pokazuju da visokointenzivne vježbe s opterećenjem izazivaju oksidativni stres, sistemske upalne procese i povećavaju razinu pokazatelja staničnih oštećenja u sportaša. Ipak, sedam dana suplementacije omega 3 masnim kiselinama mogu smanjiti navedene učinke treninga

OBESITY-RELATED CARDIOVASCULAR RISK FACTORS AFTER LONG- TERM RESISTANCE TRAINING AND GINGER SUPPLEMENTATION

Obesity and its metabolic consequences are major risk factors for cardiovascular morbidity and mortality. However, lifestyle interventions, including exercise training and dietary components may decrease cardiovascular risk. Hence, this study was conducted to assess the effects of ginger supplementation and progressive resistance training on some cardiovascular risk factors in obese men. In a randomized double-blind design, 32 obese Iranian men (BMI > 30) were assigned in to one of four groups: Placebo (PL, n = 8); ginger group (GI, n = 8) that consumed 1 gr ginger/d for 10 wk; resistance training plus placebo (RTPL, n = 8); and 1gr ginger plus resistance exercise (RTGI, n = 8). Progressive resistance training was performed three days per week for 10 weeks and included eight exercises. At baseline and after 10 weeks, body composition and anthropometric indices were measured. To identify other risk factors, venous blood samples were obtained before and 48-72 hours after the last training session for measurement of blood lipids (LDL-C, HDL-C, TG), systemic inflammation (CRP), and insulin resistance (HOMA-IR). After 10 weeks both RTGI and RTPL groups showed significant decreases in waist circumference (WC), waist-to-hip ratio (WHR), body fat percent, body fat mass, total cholesterol, and insulin resistance (p < 0.05) and a significant increase in fat free mass (FFM) (p < 0.05), while it remained unchanged in PL and GI. Further, significant decreases in the mean values of CRP were observed in all groups except PL (p < 0.05). Our results reveal that resistance training is an effective therapeutic strategy to reduce cardiovascular risk in obese Iranian men. Further, ginger supplementation alone or in combination with resistance training, also reduces chronic inflammation. However more research on the efficacy of this supplement to reduce cardiovascular risk in humans is required

The effects of physical activity on adipokines in individuals with overweight/obesity across the lifespan: A narrative review

International audienceThis narrative review summarizes current knowledge on the effects of physical activity (PA) on adipokine levels in individuals with overweight and obesity. Approximately 90 investigations including randomized control, cross-sectional and longitudinal studies that reported on the effects of a single session of PA (acute) or long-term PA (chronic) on adipokine levels in individuals with overweight/obesity were reviewed. The findings support the notion that there is consensus on the benefits of chronic exercise training-regardless of the mode (resistance vs. aerobic), intensity and cohort (healthy vs. diabetes)-on adipokine levels (such as tumour necrosis factor-alpha, interleukin-6, adiponectin, visfatin, omentin-1 and leptin). However, several confounding factors (frequency, intensity, time and type of exercise) can alter the magnitude of the effects of an acute exercise session. Available evidence suggests that PA, as a part of routine lifestyle behaviour, improves obesity complications by modulating adipokine levels. However, additional research is needed to help identify the most effective interventions to elicit the most beneficial changes in adipokine levels in individuals with overweight/obesity

The Effects of Aerobic-Resistance Training and Broccoli Supplementation on Plasma Dectin-1 and Insulin Resistance in Males with Type 2 Diabetes

Background: This study aimed to evaluate the effects of a combination of aerobic-resistance training (CARET) and broccoli supplementation on dectin-1 levels and insulin resistance in men with type 2 diabetes mellitus (T2D). Methods: Forty-four males with T2D were randomly allocated to four groups (n = 11 each group): CARET + broccoli supplement (TS), CARET + placebo (TP), control + broccoli supplement (S), and control + placebo (CP). CARET was performed three days per week for 12 weeks. TS and S groups received 10 g of broccoli supplement per day for 12 weeks. All variables were assessed at baseline and 12 weeks. Results: Plasma dectin-1 levels were decreased in TS and TP groups compared with the CP group (p < 0.05). Cardiometabolic risk factors showed significant reductions in TP and TS groups compared to S and CP groups (p < 0.05). Conclusion: The combination of CARET and broccoli supplementation produced the largest improvements in insulin resistance and dectin-1 and other complications of T2D.Health and Social Development, Faculty of (Okanagan)Medicine, Faculty ofNon UBCAnesthesiology, Pharmacology and Therapeutics, Department ofHealth and Exercise Sciences, School of (Okanagan)ReviewedFacult