Quantifying and contextualizing disinfection byproducts during the Flint Water Crisis: a case study, and framework for broader application

Total trihalomethanes (TTHMs) and other disinfection byproducts (DBPs) have been a concern in Flint, Michigan, in both delivered water and water from home water heaters. Historical TTHM data and DBP sampling results from Flint were combined with models for predicting hot water TTHMs to assess the probability of certain DBP concentrations. Results were compared with hot and cold water DBPs from a water system in Florida. Flint results were used to estimate cancer risk resulting from chronic exposure to hot water TTHMs, and compared to similar risk assessments in other water systems. Results indicate TTHM concentrations decreased in Flint following a return to water from the Detroit Water and Sewerage Department, and were very near the mean value for public drinking water systems in the United States. Measurement of other unregulated DBPs also indicated levels within the typical ranges. Monte Carlo simulations coupled with modeling of hot water TTHMs indicated a low probability of TTHMs exceeding 80 μg/L in Flint in 2016. The estimated cancer risk from exposure to TTHMs in Flint is similar to other areas. The methods used in this work can apply broadly to other water systems to de-escalate perceptions of risk following a water crisis

Expertise differences in anticipatory judgements during a temporally and spatially occluded dynamic task

There is contradictory evidence surrounding the role of critical cues in the successful anticipation of penalty kick outcome. In the current study, skilled and less-skilled soccer goalkeepers were required to anticipate spatially (full body; hip region) and temporally (–160 ms, –80 ms before, foot–ball contact) occluded penalty kicks. The skilled group outperformed the less-skilled group in all conditions. Both groups performed better in the full body, compared to hip region condition. Later temporal occlusion conditions were associated with increased performance in the correct response and correct side analysis, but not for correct height. These data suggest that there is enough postural information from the hip region for skilled goalkeepers to make highly accurate predictions of penalty kick direction, however, other regions are needed in order to make predictions of height. These data demonstrate the evolution of cues over time and have implications for anticipation training

A REFERENCES ARCHITECTURE FOR HUMAN CYBER PHYSICAL SYSTEMS - PART II: FUNDAMENTAL DESIGN PRINCIPLES FOR HUMAN-CPS INTERACTION

As automation increases qualitatively and quantitatively in safety-critical human cyber-physical systems, it is becoming more and more challenging to increase the probability or ensure that human operators still perceive key artefacts and comprehend their roles in the system. In the companion paper, we proposed an abstract reference architecture capable of expressing all classes of system-level interactions in human cyber-physical systems. Here we demonstrate how this reference architecture supports the analysis of levels of communication between agents and helps to identify the potential for misunderstandings and misconceptions. We then develop a metamodel for safe human machine interaction. Therefore, we ask what type of information exchange must be supported on what level so that humans and systems can cooperate as a team, what is the criticality of exchanged information, what are timing requirements for such interactions, and how can we communicate highly critical information in a limited time frame in spite of the many sources of a distorted perception. We highlight shared stumbling blocks and illustrate shared design principles, which rest on established ontologies specific to particular application classes. In order to overcome the partial opacity of internal states of agents, we anticipate a key role of virtual twins of both human and technical cooperation partners for designing a suitable communicati

Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.info:eu-repo/semantics/publishedVersio

LEFT – a web-based tool for the remote measurement and estimation of ecological value across global landscapes

1. The overall aim in the development of the Local Ecological Footprinting Tool (LEFT) was to design a web‐based tool that could provide quickly obtained quantitative data on ecological risk to assist landowners when making land‐use change decisions.2. The Local Ecological Footprinting Tool works for almost any region in the world and uses freely available satellite imagery, biotic and abiotic data from existing global databases, models and algorithms to deliver a customised report for a selected area within one hour of job submission.3. Biotic data automatically obtained for a selected landscape includes terrestrial vertebrate and plant species occurrence data, information on their conservation status and remotely sensed vegetation productivity. Abiotic information obtained includes temperature, precipitation, water availability, insolation, topography, elevation, distribution of urban infrastructure and location of wetlands.4. The tool performs a number of analyses on the biotic and abiotic data to produce maps for the selected area at a 30 m resolution depicting land cover type, numbers of globally threatened terrestrial vertebrate and plant species, beta‐diversity of terrestrial vertebrates and plants, habitat intactness, wetland habitat connectivity, numbers of migratory species and vegetation resilience. Results are also aggregated to produce a summary map demonstrating areas of high and low ecological risk across the selected area.5. The Local Ecological Footprinting Tool has been designed to be intuitive to use, requiring no specialised software or user expertise. Input is extremely easy and requires the user to highlight the area of interest on a map or using grid co‐ordinates. Output is delivered via the web application and comprises a customised PDF containing the maps and a zip file of geographical information system (GIS) data for the area requested. Users may run an unlimited number of LEFT analyses and download reports free of charge. In addition to the free tool described in this paper, there is also a paid service: individual LEFT analyses can be upgraded for a charge to allow access to the geographically subsetted datasets generated for each report. These data are supplied as a zip file containing raster datasets for the layers in the LEFT analysis in GeoTIFF format. These can be opened and queried in a GIS software package

In Situ Neutron Diffraction Study of the Deuteration of Isotopic Mg11B2

Isotopic Mg11B2 has been deuterated at 400 °C and 800 bar, with the production of β-Mg(11BD4)2 observed by in situ neutron diffraction. A natural MgB2 sample has been deuterated under similar conditions and studied ex situ by high resolution X-ray synchrotron diffraction. In both cases, quantitative phase analysis (QPA) indicates a ca. 43% yield of the high temperature (β) phase, with the rest of the sample composed of unreacted MgB2 and Mg or MgD2. A joint refinement of the neutron and X-ray synchrotron data has been performed, yielding a final β-Mg(11BD4)2 structure in space group Fddd, with new D positions. Anisotropically broadened (odd, odd, odd) reflections are attributed to microstructural features, rather than antiphase boundaries. QPA of the isotopic sample indicates ca. 10% of B atoms are in a noncrystalline state. A broad feature is evident in the ex situ X-ray synchrotron data, covering a wide d-spacing range from ca. 3.80–5.45 Å, consistent with the formation of amorphous Mg(BD4)2 and amorphous B. For both samples, macroscopic fusing occurs, forming an extremely hard phase with a glassy black appearance, which is hydrogen impermeable and inhibits further formation of β-Mg(BH4)2. The fused surface regions of the sample have been studied by transmission (TEM) and scanning (SEM) electron microscopy. TEM studies show amorphous regions on the surface, consistent with amorphous B, and a Mg–B–O–H phase