1995, Spatial and temporal variability of late Neogene equatorial Pacific carbonate

High-resolution, continuous records of GRAPE wet bulk density (a carbonate proxy) from Ocean Drilling Program Leg 138 provide one the opportunity for a detailed study of eastern equatorial Pacific Ocean carbonate sedimentation during the last 6 m.y. The transect of sites drilled spans both latitude and longitude in the eastern equatorial Pacific from 90° to 110°W and from 5°S to 10°N. Two modes of variability are resolved through the use of Empirical Orthogonal Function (EOF) analysis. In the presence of large tectonic and climatic boundary condition changes over the last 6 m.y., the dominant mode of spatial variability in carbonate sedimentation is remarkably constant. The first mode accounts for over 50% of the variance in the data, and is consistent with forcing by equatorial divergence. This mode characterizes both carbonate concentration and carbonate mass accumulation rate time series. Variability in the first mode is highly coherent with insolation, indicating a strong linear relationship between equatorial Pacific car bonate sedimentation and Milankovitch variability. Frequency domain analysis indicates that the coupling to equatorial divergence in carbonate sedimentation is strongest in the precession band (19-23 k.y.) and weakest though present at lower frequencies. The second mode of variability has a consistent spatial pattern of east-west asymmetry over the past 4 m.y. only; prior to 4 Ma, a different mode of spatial variability may have been present, possibly suggesting influence by closure of the Isthmus of Panama or other tectonic changes. The second mode of variability may indicate influence by CaCO3 dissolution. The second mode of variability is not highly coherent with insolation. Comparison of the modes of carbonate variability to a 4 m.y. record of benthic δ 1 8 indicates that although overall correlation between carbonate and δ 1 8 is low, both modes of variability in carbonate sedimentation are coherent with δ 1 8 changes at some frequencies. The first mode of carbonate variability is coherent with Sites 846/849 δ 1 8 at the dominant insolation periods, and the second mode is coherent at 100 k.y. during the last 2 m.y. The coherence between carbonate sedimentation and δ 1 8 in both EOF modes suggests that multiple uncorrelated modes of variability operated within the climate system during the late Neogene

Downhole logging as a paeoceanographic tool on ocean drilling program leg 138: Interface between high-resolution stratigraphy and regional syntheses

On Ocean Drilling Program (ODP) Leg 138, standard shipboard procedures were modified to allow for the real-time monitoring of several laboratory core-scanning systems that provide centimeter-scale measurements of saturated bulk density, magnetic susceptibility and digital color reflectance. These continuous, high-resolution data sets were used to ensure the proper offset of multiple holes and to splice together complete sedimentary sections. Typically, the spliced, continuousediment sections were found to be about 10% longer than the section drilled, as measured by the length of the drill string. While the source of this elongation is not yet fully understood, it must be compensated for in order to property determine sediment fluxes and mass accumulation rates. Downhole logging, in conjunction with inverse correlation techniques provided a means to determine where the distortion occurred and to correct back to true in sire depths. Downhole logging also provides a means, through the generation of synthetic seismograms, of precisely relating the paleoceanographic events found in the core record to the high-resolution seismic record. Once correlated to the seismic record, the spatial and temporal extent of paleoceanographic events can be traced well beyond the borehole. Most seismic events in the equatorial Pacific are related to rapid changes in carbonate contenthat, in turn, are related to both productivity events (often expressed as monospecific laminated diatom oozes) and times of enhanced dissolution. While many of these events may have oceanwide extent, others, like the absence of carbonate in the late-Miocene to Recent in the Guatemala Basin have been shown to be regional and confined to only the deeper portions of the Guatemala Basin. As we identify and trace specific paleoceanographic events in the seismic record, we can begin to explore the response of the ocean through gradients of latitude, productivity, and depth

Downhole Logging as a Paeoceanographic Tool on Ocean Drilling Program Leg 138: Interface Between High-Resolution Stratigraphy and Regional Syntheses

On Ocean Drilling Program (ODP) Leg 138, standard shipboard procedures were modified to allow for the real-time monitoring of several laboratory core-scanning systems that provide centimeter-scale measurements of saturated bulk density, magnetic susceptibility and digital color reflectance. These continuous, high-resolution data sets were used to ensure the proper offset of multiple holes and to splice together complete sedimentary sections. Typically, the spliced, continuous sediment sections were found to be about 10% longer than the section drilled, as measured by the length of the drill string. While the source of this elongation is not yet fully understood, it must be compensated for in order to property determine sediment fluxes and mass accumulation rates. Downhole logging, in conjunction with inverse correlation techniques provided a means to determine where the distortion occurred and to correct back to true in situ depths. Downhole logging also provides a means, through the generation of synthetic seismograms, of precisely relating the paleoceanographic events found in the core record to the high-resolution seismic record. Once correlated to the seismic record, the spatial and temporal extent of paleoceanographic events can be traced well beyond the borehole. Most seismic events in the equatorial Pacific are related to rapid changes in carbonate content that, in turn, are related to both productivity events (often expressed as monospecific laminated diatom oozes) and times of enhanced dissolution. While many of these events may have oceanwide extent, others, like the absence of carbonate in the late-Miocene to Recent in the Guatemala Basin have been shown to be regional and confined to only the deeper portions of the Guatemala Basin. As we identify and trace specific paleoceanographic events in the seismic record, we can begin to explore the response of the ocean through gradients of latitude, productivity, and depth

Predicting protein decomposition: the case of aspartic-acid racemization kinetics

The increase in proportion of the non-biological (D-) isomer of aspartic acid (Asp) relative to the L- isomer has been widely used in archaeology and geochemistry as a tool for dating. The method has proved controversial, particularly when used for bones. The non-linear kinetics of Asp racemization have prompted a number of suggestions as to the underlying mechanism(s) and have led to the use of mathe- matical transformations which linearize the increase in D-Asp with respect to time. Using one example, a suggestion that the initial rapid phase of Asp racemization is due to a contribution from asparagine (Asn), we demonstrate how a simple model of the degradation and racemization of Asn can be used to predict the observed kinetics. A more complex model of peptide bound Asx (Asn+Asp) racemization, which occurs via the formation of a cyclic succinimide (Asu), can be used to correctly predict Asx racemi- zation kinetics in proteins at high temperatures (95-140 °C). The model fails to predict racemization kinetics in dentine collagen at 37 °C. The reason for this is that Asu formation is highly conformation dependent and is predicted to occur extremely slowly in triple helical collagen. As conformation strongly in£uences the rate of Asu formation and hence Asx racemization, the use of extrapolation from high temperatures to estimate racemization kinetics of Asx in proteins below their denaturation temperature is called into question. In the case of archaeological bone, we argue that the D:L ratio of Asx re£ects the proportion of non- helical to helical collagen, overlain by the e¡ects of leaching of more soluble (and conformationally unconstrained) peptides. Thus, racemization kinetics in bone are potentially unpredictable, and the proposed use of Asx racemization to estimate the extent of DNA depurination in archaeological bones is challenged

Feasibility of a transmucosal sublingual fentanyl tablet as a procedural pain treatment in colonoscopy patients: a prospective placebo-controlled randomized study

Since patients often experience pain and unpleasantness during a colonoscopy, the present study aimed to evaluate the efficacy and safety of sublingually administered fentanyl tablets for pain treatment. Furthermore, since the use of intravenous drugs significantly increases colonoscopy costs, sublingual tablets could be a cost-effective alternative to intravenous sedation. We conducted a prospective placebo-controlled randomized study of 158 patients to evaluate the analgesic effect of a 100 µg dose of sublingual fentanyl administered before a colonoscopy. Pain, sedation, nausea, and satisfaction were assessed during the colonoscopy by the patients as well as the endoscopists and nurses. Respiratory rate and peripheral arteriolar oxygen saturation were monitored throughout the procedure. There were no differences between the fentanyl and placebo groups in any of the measured variables. The median pain intensity values, as measured using a numerical rating scale, were 4.5 in the fentanyl group and 5 in the placebo group. The sedation and oxygen saturation levels and the respiratory rate did not differ between the groups. The majority of the colonoscopies were completed.Our results indicate that a 100 µg dose of sublingual fentanyl is not beneficial compared to the placebo in the treatment of procedural pain during a colonoscopy.</p

Exploring dust around HD142527 down to 0.025" / 4au using SPHERE/ZIMPOL

We have observed the protoplanetary disk of the well-known young Herbig star HD 142527 using ZIMPOL Polarimetric Differential Imaging with the VBB (Very Broad Band, ~600-900nm) filter. We obtained two datasets in May 2015 and March 2016. Our data allow us to explore dust scattering around the star down to a radius of ~0.025" (~4au). The well-known outer disk is clearly detected, at higher resolution than before, and shows previously unknown sub-structures, including spirals going inwards into the cavity. Close to the star, dust scattering is detected at high signal-to-noise ratio, but it is unclear whether the signal represents the inner disk, which has been linked to the two prominent local minima in the scattering of the outer disk, interpreted as shadows. An interpretation of an inclined inner disk combined with a dust halo is compatible with both our and previous observations, but other arrangements of the dust cannot be ruled out. Dust scattering is also present within the large gap between ~30 and ~140au. The comparison of the two datasets suggests rapid evolution of the inner regions of the disk, potentially driven by the interaction with the close-in M-dwarf companion, around which no polarimetric signal is detected.Comment: 11 pages, 7 figures, accepted for publication in A

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction

This study aimed to determine possible effects of voriconazole and posaconazole on the pharmacokinetics and pharmacological effects of sublingual buprenorphine.We used a randomized, placebo-controlled crossover study design with 12 healthy male volunteers. Subjects were given a dose of 0.4 mg (0.6 mg during placebo phase) sublingual buprenorphine after a 5-day oral pretreatment with either (i) placebo, (ii) voriconazole 400 mg twice daily on the first day and 200 mg twice daily thereafter or (iii) posaconazole 400 mg twice daily. Plasma and urine concentrations of buprenorphine and its primary active metabolite norbuprenorphine were monitored over 18 h and pharmacological effects were measured.Compared to placebo, voriconazole increased the mean area under the plasma concentration-time curve (AUC(0-a)) of buprenorphine 1.80-fold (90 % confidence interval 1.45-2.24; P < 0.001), its peak concentration (C-max) 1.37-fold (P < 0.013) and half-life (t (A1/2) ) 1.37-fold (P < 0.001). Posaconazole increased the AUC0(0-a) of buprenorphine 1.25-fold (P < 0.001). Most of the plasma norbuprenorphine concentrations were below the limit of quantification (0.05 ng/ml). Voriconazole, unlike posaconazole, increased the urinary excretion of norbuprenorphine 1.58-fold (90 % confidence interval 1.18-2.12; P < 0.001) but there was no quantifiable parent buprenorphine in urine. Plasma buprenorphine concentrations correlated with the pharmacological effects, but the effects did not differ significantly between the phases.Voriconazole, and to a minor extent posaconazole, increase plasma exposure to sublingual buprenorphine, probably via inhibition of cytochrome P450 3 A and/or P-glycoprotein. Care should be exercised in the combined use of buprenorphine with triazole antimycotics, particularly with voriconazole, because their interaction can be of clinical importance

Benthic foraminifer stable isotope record from Site 849 (0 - 5 Ma) : local and global climate changes

Benthic foraminifer and δ¹³C data from Site 849, on the west flank of the East Pacific Rise (0°11'N, 110°3l'W; 3851 m), give relatively continuous records of deep Pacific Ocean stable isotope variations between 0 and 5 Ma. The mean sample spacing is 4 k.y. Most analyses are from Cibicides wuellerstorfi> but isotopic offsets relative to Uvigerina peregrina appear roughly constant. Because of its location west of the East Pacific Rise, Site 849 yields a suitable record of mean Pacific Ocean δ¹³C, which approximates a global oceanic signal. The ~lOO-k.y.-period climate cycle, which is prevalent in δ¹⁸O does not dominate the long-term δ¹³C record. For δ¹³C, variations in the -400- and 41-k.y. periods are more important. Phase lags of δ¹³C relative to ice volume in the 41- and 23-k.y. bands are consistent with δ¹³C as a measure of organic biomass. A model-calculated exponential response time of 1-2 k.y. is appropriate for carbon stored in soils and shallow sediments responding to glacial-interglacial climate change. Oceanic δ¹³C leads ice volume slightly in the 100-k.y. band, and this suggests another process such as changes in continental weathering to modulate mean river δ¹³C at long periods. The δ¹³C record from Site 849 diverges from that of Site 677 in the Panama Basin mostly because of decay of ¹³C-depleted organic carbon in the relatively isolated Panama Basin. North Atlantic to Pacific δ¹³C differences calculated using published data from Sites 607 and 849 reveal variations in Pliocene deep water within the range of those of the late Quaternary. Maximum δ¹³C contrast between these sites, which presumably reflects maximum influx of high-δ¹³C northern source water into the deep North Atlantic Ocean, occurred between 1.3 and 2.1 Ma, well after the initiation of Northern Hemisphere glaciation. Export of high-δ¹³C North Atlantic Deep Water from the Atlantic to the circumpolar Antarctic, as recorded by published δ'3C data from Subantarctic Site 704, appears unrelated to the North Atlantic-Pacific δ¹³C contrast. To account for this observation, we suggest that deep-water formation in the North Atlantic reflects northern source characteristics, whereas export of this water into the circumpolar Antarctic reflects Southern Hemisphere wind forcing. Neither process appears directly linked to ice-volume variations

Spatial and temporal variability of late Neogene Equatorial Pacific carbonate : ODP Leg 138

High resolution, continuous records of GRAPE wet bulk density (a carbonate proxy) from Ocean Drilling Program Leg 138 provide one the opportunity for a detailed study of eastern equatorial Pacific Ocean carbonate sedimentation during the last 6 m.y. The transect of sites drilled spans both latitude and longitude in the eastern equatorial Pacific from 90° to 110°W and from 5°S to 10°N. Two modes of variability are resolved through the use of Empirical Orthogonal Function (EOF) analysis. In the presence of large tectonic and climatic boundary condition changes over the last 6 m.y., the dominant mode of spatial variability in carbonate sedimentation is remarkably constant. The first mode accounts for over 50% of the variance in the data, and is consistent with forcing by equatorial divergence. This mode characterizes both carbonate concentration and carbonate mass accumulation rate time series. Variability in the first mode is highly coherent with insolation, indicating a strong linear relationship between equatorial Pacific car bonate sedimentation and Milankovitch variability. Frequency domain analysis indicates that the coupling to equatorial divergence in carbonate sedimentation is strongest in the precession band (19 23 k.y.) and weakest though present at lower frequencies. The second mode of variability has a consistent spatial pattern of east west asymmetry over the past 4 m.y. only; prior to 4 Ma, a different mode of spatial variability may have been present, possibly suggesting influence by closure of the Isthmus of Panama or other tectonic changes. The second mode of variability may indicate influence by CaCO₃ dissolution. The second mode of variability is not highly coherent with insolation. Comparison of the modes of carbonate variability to a 4 m.y. record of benthic δ¹⁸O indicates that although overall correlation between carbonate and δ¹⁸O is low, both modes of variability in carbonate sedimentation are coherent with δ¹⁸O changes at some frequencies. The first mode of carbonate variability is coherent with Sites 846/849 δ¹⁸O at the dominant insolation periods, and the second mode is coherent at 100 k.y. during the last 2 m.y. The coherence between carbonate sedimentation and δ¹⁸O in both EOF modes suggests that multiple uncorrelated modes of variability operated within the climate system during the late Neogene

Refinement of a high-resolution, continuous sedimentary section for studying Equatorial Pacific Ocean paleoceanography, Leg 138

Ocean Drilling Program (ODP) Leg 138 was designed to study the late Neogene paleoceanography of the equatorial Pacific Ocean at time scales of thousands to millions of years. Crucial to this objective was the acquisition of continuous, high-resolution sedimentary records. It is well known that between successive advanced piston corer (APC) cores, portions of the sedimentary sequence often are absent, despite the fact that core recovery is often recorded as 100%. To confirm that a continuous sedimentary sequence was sampled, each of the 11 drill sites was multiple-APC-cored. At each site, continuously measured records of magnetic susceptibility, gamma-ray attenuation porosity evaluator (GRAPE), wet-bulk density, and digital color reflectance were used to monitor section recovery. These data were used to construct a composite depth section while at the site. This strategy often verified 100% recovery of the complete sedimentary sequence with two or three offset piston-cored holes. Here, these initial efforts have been extended to document the recovery of a complete sediment section and to investigate sources of error associated with sediment density measurements and changes in local sedimentation rates. At Sites 846 through 852, fine-scale correlation (on the order of centimeters) of the GRAPE records was accomplished using the inverse correlation techniques of Martinson et al. (1982). Having a common depth scale for all holes at each site facilitated comparison of high-resolution data from different holes. After refining the interhole correlation, GRAPE records from adjacent holes were "stacked" to produce a less noisy estimate of sediment wet-bulk density for Sites 846 through 852. The continuity of the stacked GRAPE record is confirmed with reflectance and susceptibility records. The resulting stacked GRAPE records have a temporal resolution of less than 1000 yr for the past 5 m.y. Moreover, the stacking procedure allows for development of error estimates for measurements present in more than one hole. An important advantage provided by this framework is that one can determine the range of sedimentation variability between adjacent holes at a given site. This variability is caused by local sedimentation variability and by artifacts of the coring process. We demonstrate that the depth domain changes in sedimentation variability required to correlate among adjacent holes are larger than the changes induced by time-scale tuning procedures