A framework for implementing formally verified resource-bounded smart space systems

© 2017, Springer Science+Business Media New York. Context-aware computing is a mobile computing paradigm that helps designing and implementing next generation smart applications, where personalized devices interact with users in smart environments. Development of such applications is inherently complex due to these applications adapt to changing contextual information and they often run on resource-bounded devices. Most of the existing context-aware development frameworks are centralized, adopt client–server architecture, and do not consider resource limitations of context-aware devices. This paper presents a systematic framework to modelling and implementation of resource-bounded multi-agent context-aware systems on Android devices. The proposed framework makes use of semantic technologies for context modelling and reasoning about resource-bounded context-aware agents, Android powered smartphones as development platform, a suitable communication model and declarative rule-based programming as a preferred development language

Effect of delay harvest on seed quality and germination of three varieties of soybean (Glycinemax) seeds

The loss in soybean seed quality owing to adverse environmental reasons is unavoidable, particularly in the tropics. Seed ability to germinate and produce a vigorous seedling is a significant characteristic for any seed-propagated crop. Seed deterioration is a harmful feature of agriculture crops which hindered quality seed of Soybean. Thus, the purpose of the study is to investigate the relationship between seed deterioration and physiological changes of delayed harvest soybean seeds. Three soybean varieties which are AGS-190, Cikurai, and Willis were used as planting in the field at Universiti Putra Malaysia as materials in this experiment. The seeds were harvested at harvest maturity HM (H1) demonstrating 95% of the pods have reached their mature brown color and 2-week delay after HM (H2). The experiment was conducted in a complete randomized design (CRD) with three replicates. The result showed that seed deterioration of larger seeded soybean varieties can be increased at a 2-week delay after harvest maturity stage. Seed quality of soybean was affected by field weather environment during harvest date. AGS190 was the most sensitive to adverse weather surroundings as shown by deterioration of seed quality at a 2-week delay after harvest maturity stage. Loss of seed viability and vigor demonstrated depending on harvest date and directly related to increase in the level of phomopsis sp. infection. Germination percentage, tetrazolium test seed viability and vigor are negatively correlated with electrical conductivity and phomopsis sp., while in small seeded varieties was less seed deterioration

Solitary brain metastasis: A rare initial presentation of prostate carcinoma

Cerebral metastasis as an initial clinical presentation of prostate carcinoma is extremely rare. Usually, patients have widespread metastasis in the body before presenting with brain metastasis. In the absence of extensive metastasis, especially without bony metastasis, only brain metastasis is an unusual presentation of the disease. We report a case of a 59-years-old patient who presented with a lack of concentration and decreased vision. Magnetic resonance imaging (MRI) of the brain revealed a large right parietal-occipital space-occupying lesion. He underwent surgery and the pathological diagnosis of the tumor turned out to be metastatic prostate carcinoma. Further evaluation by a whole-body computed tomography (CT) scan revealed an enlarged prostate with no other metastatic deposit and a mildly raised level of prostate-specific antigen (PSA). It was possible for us to provide this patient with multi-modality treatment with the help of multidisciplinary tumor board meetings. Further studies addressing the biological as well as clinical characteristics of prostate carcinoma with this rare metastatic presentation will help us to define prognostic factors and therapeutic intervention and will help us to understand the basis of this unique presentation without bone metastasi

Type 2 diabetes and its correlates among adults in Bangladesh: a population based stud

Type 2 diabetes is one of the most prevalent non-communicable diseases in Bangladesh. However, the correlates of type 2 diabetes among adults in Bangladesh remain unknown. We aimed to investigate the correlates of type 2 diabetes among the adults in Bangladesh. Methods : We conducted a cross-sectional study using data from the nationally representative 2011 Bangladesh Demographic and Health Survey. A random sample of 7,543 (3,823 women and 3,720 men) adults of age 35 years and older from both urban and rural areas, who participated in the survey was included. Diabetes was defined as having a fasting plasma blood glucose level of ≥ 7 mm/L or taking diabetes medication during the survey. Hypothesized factors, e.g., age, sex, education, place of residence, social status, body mass index, and hypertension were considered in the analyses. Multivariable logistic regression models were used to identify the important correlates of type 2 diabetes. Results : Among the respondents, the overall prevalence of diabetes was 11 %, and the prevalence was slightly higher in women (11.2 %) than men (10.6 %). Respondents with the age group of 55–59 years had higher odds of having diabetes (odds ratios (OR) = 2.37, 95 % confidence interval (CI): 1.76–3.21) than the age group of 35–39 years. Moreover, respondents who had higher educational attainment (OR = 1.67, 95 % CI: 1.18–2.36) and higher social status (OR = 2.01, 95 % CI: 1.50–2.70) had higher odds of having diabetes than the respondents with no education and lower social status, respectively. We also found socioeconomic status, place of residence (rural or urban), regions of residence (different divisions), overweight and obesity, and hypertension as significant correlates of type 2 diabetes in Bangladesh. Conclusions: Our study shows that older age, higher socioeconomic status, higher educational attainment, hypertension, and obesity were found to be significant correlates of type 2 diabetes. Need-based policy program strategies including early diagnosis, awareness via mass media, and health education programs for changing lifestyles should be initiated for older age, wealthy, and/or higher educated individuals in Bangladesh. Moreover, area-specific longitudinal research is necessary to find out the underlying causes of regional variations

Managing soft tissue sarcomas in a developing country: Are prognostic factors similar to those of developed world?

Background: Managing soft tissue sarcomas (STS) in a developing country with limited financial resources and a poor health referral system is a challenge. Presenting late, these extremity STS are prone to recurrence despite apparently complete resection. This study aimed to explore and compare the impact of clinico-pathological factors on recurrence and survival in Pakistan with the corresponding figures quoted from the developed world. Methods: An institutional review was performed on all patients with primary STS of the extremities operated on between 1994 and 2008. The prognostic influence of clinical, pathologic, and treatment variables on local recurrence free survival (LRFS), metastasis free survival (MFS) and overall survival (OS) were analyzed by univariate and multivariate Cox regression analysis and Kaplan Meier survival curves. Results: A total of 84 patients with a mean age of 41.8 ± 21.9 years were included in the study. The local recurrence rate was 14.3% after a median of 6 (mean 7.4) months. Metastases occurred in 7 patients (8.3%) and 65 patients were alive without evidence of disease after a mean follow-up of 52.6 ± 39.8 months. Tumor size \u3e 5 cm, grade 3 tumors and margin \u3c 10 mm significantly increased local recurrence rates. A margin ≥ 10 mm and age \u3c 45 years significantly enhanced cumulative survival. Significant multivariate risk factors for metastases were margin \u3c 10 mm and tumor grade G3. Conclusions: Despite a poor health referral system in our country, our results are no different from those reported from the developed world. Surgical margins and tumor grade prognostically influenced LRFS, MFS and OS

Deterioration of quality soybean seeds (Glycine Max (L.) Merr. AGS 190) at harvest stages, seed moisture content and storage temperature in Malaysia

Soybean [Glycine max (L.) Merill AGS 190) is an important vegetables and oil in the Asian communities like Malaysia. Seed deterioration is a harmful feature of agriculture crops which hindered quality seed of Soybean. Thus, the purpose of the study is to determine the effect of non-ultra-dry and ultra-dry seed moisture content stored in room temperature and cold room conditions for seed harvested stages on the quality or seed deterioration of soybean seeds (AGS 190) which grown under the humid tropical region. This study was conducted at Faculty of Agriculture, University Putra Malaysia in three harvested stages such as R6 (Full seed stage), R7 (Commencement of maturity period), and R8 (Fully maturity stage), moisture content (12% non-ultra-dry and ≤5% ultra-dry) and storage temperature (room storage at 25 to 30ºC and cold room storage at 10ºC). The result of this study showed that the seed deterioration rate was less in harvest stage R7 compared to R6 and R8 especially for ultra-dry seeds. In addition, seed deterioration can decrease at room temperature by the ultra-dry treatment compared non-ultra-dry but deterioration was higher for non-ultra-dry seed during storage at room temperature than cold room

Impact of peer review in the radiation treatment planning process: Experience of a tertiary care university hospital in Pakistan

Purpose: To evaluate and report the frequency of changes in radiation therapy treatment plans after peer review in a simulation review meeting once a week.Materials and Methods: Between July 1 and August 31, 2016, the radiation plans of 116 patients were discussed in departmental simulation review meetings. All plans were finalized by the primary radiation oncologist before presenting them in the meeting. A team of radiation oncologists reviewed each plan, and their suggestions were documented as no change, major change, minor change, or missing contour. Changes were further classified as changes in clinical target volume, treatment field, or dose. All recommendations were stratified on the basis of treatment intent, site, and technique. Data were analyzed by Statistical Package for the Social Sciences and are presented descriptively.Results: Out of 116 plans, 26 (22.4%) were recommended for changes. Minor changes were suggested in 15 treatment plans (12.9%) and a major change in 10 (8.6%), and only one plan was suggested for missing contour. The frequency of change recommendations was greater in radical radiation plans than in palliative plans (92.3% v 7.7%). The head and neck was the most common treatment site recommended for any changes (42.3%). Most of the changes were recommended in the technique planned with three-dimensional conformal radiation therapy (50%). Clinical target volume (73.1%) was identified as the most frequent parameter suggested for any change, followed by treatment field (19.2%) and dose (0.08%).Conclusion: Peer review is an important tool that can be used to overcome deficiencies in radiation treatment plans, with a goal of improved and individualized patient care. Our study reports changes in up to a quarter of radiotherapy plans

Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway

Background Methanol extract (MECN) of Clinacanthus nutans Lindau leaves (family Acanthaceae) demonstrated peripherally and centrally mediated antinociceptive activity via the modulation of opioid/NO-mediated, but cGMP-independent pathway. In the present study, MECN was sequentially partitioned to obtain petroleum ether extract of C. nutans (PECN), which was subjected to antinociceptive study with aims of establishing its antinociceptive potential and determining the role of opioid receptors and l–arginine/nitric oxide/cyclic-guanosine monophosphate (l–arg/NO/cGMP) pathway in the observed antinociceptive activity. Methods The antinociceptive potential of orally administered PECN (100, 250, 500 mg/kg) was studied using the abdominal constriction-, hot plate- and formalin-induced paw licking-test in mice (n = 6). The effect of PECN on locomotor activity was also evaluated using the rota rod assay. The role of opioid receptors was determined by pre-challenging 500 mg/kg PECN (p.o.) with antagonist of opioid receptor subtypes, namely β–funaltrexamine (β–FNA; 10 mg/kg; a μ-opioid antagonist), naltrindole (NALT; 1 mg/kg; a δ-opioid antagonist) or nor–binaltorphimine (nor–BNI; 1 mg/kg; a κ-opioid antagonist) followed by subjection to the abdominal constriction test. In addition, the role of l–arg/NO/cGMP pathway was determined by prechallenging 500 mg/kg PECN (p.o.) with l–arg (20 mg/kg; a NO precursor), 1H-[1, 2, 4] oxadiazolo [4,3-a]quinoxalin-1-one (ODQ; 2 mg/kg; a specific soluble guanylyl cyclase inhibitor), or the combinations thereof (l–arg + ODQ) for 5 mins before subjection to the abdominal constriction test. PECN was also subjected to phytoconstituents analyses. Results PECN significantly (p  0.05) affect the locomotor activity of treated mice. The antinociceptive activity of PECN was significantly (p  0.05) affected by ODQ. HPLC analysis revealed the presence of at least cinnamic acid in PECN. Conclusion PECN exerted antinocicpetive activity at peripheral and central levels possibly via the activation of non-selective opioid receptors and modulation of the NO-mediated/cGMP-independent pathway partly via the synergistic action of phenolic compounds