Imide and isatin derivatives as β-lactam mimics of β-lactam antibiotics

Activated γ-lactams, which are derivatives of succinimide, phthalimide and isatin with suitable elements of molecular recognition, have been synthesised as mimics of the ß-lactam antibiotics and their chemical and biological reactivity determined

‘Walking ... just walking’: how children and young people’s everyday pedestrian practices matter

In this paper we consider the importance of ‘walking… just walking’ for many children and young people’s everyday lives. We will show how, in our research with 175 9-16-year-olds living in new urban developments in south-east England, some particular (daily, taken-for-granted, ostensibly aimless) forms of walking were central to the lives, experiences and friendships of most children and young people. The main body of the paper highlights key characteristics of these walking practices, and their constitutive role in these children and young people’s social and cultural geography. Over the course of the paper we will argue that ‘everyday pedestrian practices’ (after Middleton 2010, 2011) like these require us to think critically about two bodies of geographical and social scientific research. On one hand, we will argue that the large body of research on children’s spatial range and independent mobility could be conceptually enlivened and extended to acknowledge bodily, social, sociotechnical and habitual practices. On the other hand, we will suggest that the empirical details of such practices should prompt critical reflection upon the wonderfully rich, multidisciplinary vein of conceptualisation latterly termed ‘new walking studies’ (Lorimer 2011). Indeed, in conclusion we shall argue that the theoretical vivacity of walking studies, and the concerns of more applied empirical approaches such as work on children’s independent mobility, could productively be interrelated. In so doing we open out a wider challenge to social and cultural geographers, to expedite this kind of interrelation in other research contexts

Children Living in Sustainable Built Environments: New Urbanisms, New Citizens

Urban living has dramatically changed over the past generation, refashioning children’s relationships with the towns and cities in which they live, and the modes of living within them. Focusing on the global shift in urban planning towards sustainable urbanism - from master planned ‘sustainable communities’, to the green retrofitting of existing urban environments - Children Living in Sustainable Built Environments offers a critical analysis of the challenges, tensions and opportunities for children and young people living in these environments. Drawing upon original data, Children Living in Sustainable Built Environments demonstrates how the needs, interests and participation of children and young people often remain inferior to the design, planning and local politics of new urban communities. Considering children from their crucial role as residents engaging and contributing to the vitalities of their community, to their role as consumers using and understanding sustainable design features, the book critically discusses the prospects of future inclusion of children and young people as a social group in sustainable urbanism. Truly interdisciplinary, Children Living in Sustainable Built Environments forms an original theoretical and empirical contribution to the understanding of the everyday lives of children and young people and will appeal to academics and students in the fields of education, childhood studies, sociology, anthropology, human geography and urban studies, as well as policy-makers, architects, urban planners and other professionals working on sustainable urban designs. Drawing upon original data, Children Living in Sustainable Built Environments demonstrates how the needs, interests and participation of children and young people often remain inferior to the design, planning and local politics of new urban communities. Considering children from their crucial role as residents engaging and contributing to the vitalities of their community, to their role as consumers using and understanding sustainable design features, the book critically discusses the prospects of future inclusion of children and young people as a social group in sustainable urbanism. Truly interdisciplinary, Children Living in Sustainable Built Environments forms an original theoretical and empirical contribution to the understanding of the everyday lives of children and young people and will appeal to academics and students in the fields of education, childhood studies, sociology, anthropology, human geography and urban studies, as well as policy-makers, architects, urban planners and other professionals working on sustainable urban designs

Articulating encounters between children and plastics

In the context of global concerns about plastics, this paper sets out and exemplifies a research agenda for articulating children’s encounters with plastics. The paper analyses data co-produced with 11–15 year-olds through interviews, app-based research and experimental/arts-led workshops. It moves beyond scholarship in health and environmental sciences, and in environmental education research, to outline a far richer range of ways to conceptualise children’s encounters with plastics, based in children’s everyday, embodied and emotive interactions with plastics

Barriers and facilitators to the implementation of individual placement and support (IPS) for patients with offending histories in the community: The United Kingdom experience

IntroductionWe aimed to identify the barriers and facilitators to the implementation of a high fidelity individual placement and support service in a community forensic mental health setting.MethodIn-depth interviews were conducted with clinical staff (n = 11), patients (n = 3), and employers (n = 5) to examine barriers and facilitators to implementation of a high fidelity individual placement and support service. Data was analysed using thematic analysis, and themes were mapped onto individual placement and support fidelity criteria.ResultsBarriers cited included competing interests between employment support and psychological therapies, perceptions of patients’ readiness for work, and concerns about the impact of returning to work on welfare benefits. Facilitators of implementation included clear communication of the benefits of individual placement and support, inter-disciplinary collaboration, and positive attitudes towards the support offered by the individual placement and support programme among stakeholders. Offences, rather than mental health history, were seen as a key issue from employers’ perspectives. Employers regarded disclosure of offending or mental health history as important to developing trust and to gauging their own capacity to offer support.ConclusionsImplementation of individual placement and support in a community mental health forensic setting is complex and requires robust planning. Future studies should address the barriers identified, and adaptations to the individual placement and support model are needed to address difficulties encountered in forensic settings