Experience of sleep disruption in primary Sjögren’s syndrome: A focus group study

Introduction: Primary Sjögren’s syndrome is the third most common systemic autoimmune rheumatic disease, following rheumatoid arthritis and systemic lupus erythematosus, and results in dryness, fatigue, discomfort and sleep disturbances. Sleep is relatively unexplored in primary Sjögren’s syndrome. We investigated the experiences of sleep disturbances from the viewpoint of primary Sjögren’s syndrome patients and their partners and explored the acceptability of cognitive behavioural therapy for insomnia. Method: We used focus groups to collect qualitative data from 10 patients with primary Sjögren’s syndrome and three partners of patients. The data were recorded, transcribed verbatim and analysed using thematic analysis. Results: Five themes emerged from the data: (a) Experience of sleep disturbances; (b) variation and inconsistency in sleep disturbances; (c) the domino effect of primary Sjögren’s syndrome symptoms; (d) strategies to manage sleep; (e) acceptability of evidence-based techniques. Sleep disturbances were problematic for all patients, but specific disturbances varied between participants. These included prolonged sleep onset time and frequent night awakenings and were aggravated by pain and discomfort. Patients deployed a range of strategies to try and self-manage. Cognitive behavioural therapy for insomnia was seen as an acceptable intervention, as long as a rationale for its use is given and it is tailored for primary Sjögren’s syndrome. Conclusion: Primary Sjögren’s syndrome patients described a range of sleep disturbances. Applying tailored, evidence-based sleep therapy interventions may improve sleep, severity of other primary Sjögren’s syndrome symptoms and functional ability

A model realisation of the Jaffe-Wilczek correlation for pentaquarks

We discuss a realisation of the pentaquark structure proposed by Jaffe and Wilczek within a simple quark model with colour-spin contact interactions and coloured harmonic confinement, which accurately describes the $\Delta-N$ splitting. In this model spatially compact diquarks are formed in the pentaquark but no such compact object exists in the nucleon. The colour-spin attraction brings the Jaffe-Wilczek-like state down to a low mass, compatible with the experimental observation and below that of the naive ground state with all $S$-waves. We find, however, that although these trends are maintained, the extreme effects observed do not survive the required ``smearing'' of the delta function contact interaction. We also demonstrate the weakness of the ``schematic'' approximation when applied to a system containing a $P$-wave. An estimate of the anti-charmed pentaquark mass is made which is in line with the Jaffe-Wilczek prediction and significantly less than the value reported by the H1 collaboration.Comment: 10 pages, uses psfra

Alterations in MDCK and LLC-PK1 Cells Exposed to Oxalate and Calcium Oxalate Monohydrate Crystals

Structural analysis of human kidney stones reveals the presence of cellular membranes and other cell fragments. Experimentally, calcium oxalate crystallization is facilitated when an exogenous nephrotoxin is given with ethylene glycol, thus providing cellular degradation products to act as heterogenous nuclei. In this report, we tested whether oxalate alone could act as a cell toxin capable of producing damaged cells without the presence of an exogenous agent. Cultured LLC-PK1 and MDCK cells, when exposed to 1.0 mmol KOx, a concentration at the limit of metastability for calcium oxalate nucleation, were severely damaged as measured by specific lactate dehydrogenase (LDH) release in the spent media and by trypan blue exclusion. This effect was magnified by the addition of pre-formed calcium oxalate monohydrate crystals; the injury was significantly amplified when compared to exposure to oxalate alone. Scanning electron microscopy studies illustrated attachment of crystals to cells with loss of cell-to-cell and cell-to-substrate contact, as cells were released from the monolayer. In both oxalate and combined crystal-oxalate studies, more cells were released from the monolayer and exhibited considerably more damage when compared to controls. Oxalate, at the limit of metastability for calcium oxalate, is a cell toxin and can produce cellular degradation products. This effect is increased significantly by the addition of calcium oxalate monohydrate crystals

An Accessible Chat Prototype for Screen Reader Users in Mobile Devices

[Poster] 15th International Conference on Human–Computer Interaction (HCI International 2013), Las Vegas (Nevada, USA), 21–26 July 2013Chats present accessibility problems for screen reader users. This work presents a prototype of an accessible chat for Mobile Devices (MD). The main aim of this research is to remove the accessibility barriers that screen reader users face when they use a chat in a MD. Thus, this prototype is based on the requirements which have been elicited considering background research and with the use of Software Engineering (SE) and Human Computer Interaction (HCI) methods as well as accessibility standards and guidelines.This research work has been partially supported by MA2VICMR (S2009/TIC-1542) and MULTIMEDICA (TIN2010-20644-C03-01)Publicad

Chiral Behaviour of the Rho Meson in Lattice QCD

In order to guide the extrapolation of the mass of the rho meson calculated in lattice QCD with dynamical fermions, we study the contributions to its self-energy which vary most rapidly as the quark mass approaches zero; from the processes $\rho \to \omega \pi$ and $\rho \to \pi \pi$. It turns out that in analysing the most recent data from CP-PACS it is crucial to estimate the self-energy from $\rho \to \pi \pi$ using the same grid of discrete momenta as included implicitly in the lattice simulation. The correction associated with the continuum, infinite volume limit can then be found by calculating the corresponding integrals exactly. Our error analysis suggests that a factor of 10 improvement in statistics at the lowest quark mass for which data currently exists would allow one to determine the physical rho mass to within 5%. Finally, our analysis throws new light on a long-standing problem with the J-parameter.Comment: 13 pages, 7 figures. Full analytic forms of the self-energies are included and a correction in the omega-pi self-energ

Communication and Low Mood (CALM): a randomized controlled trial of behavioural therapy for stroke patients with aphasia

Objective: The aim was to evaluate behavioural therapy as a treatment for low mood in people with aphasia. Design: A randomized controlled trial comparing behavioural therapy plus usual care with a usual care control. Potential participants with aphasia after stroke were screened for the presence of low mood. Those who met the criteria and gave consent were randomly allocated. Setting: Participants were recruited from hospital wards, community rehabilitation, speech and language therapy services and stroke groups. Subjects: Of 511 people with aphasia identified, 105 had low mood and were recruited. Interventions: Behavioural therapy was offered for up to three months. Outcomes were assessed three and six months after random allocation. Main measures: Stroke Aphasic Depression Questionnaire, Visual Analog Mood Scales ‘sad’ item, and Visual Analogue Self-Esteem Scale. Results: Participants were aged 29 to 94 years (mean 67.0, SD 13.5) and 66 (63%) were men. Regression analysis showed that at three months, when baseline values and communication impairment were controlled for, group allocation was a significant predictor of the Stroke Aphasic Depression Questionnaire (P < 0.05), visual analogue ‘sad’ (P = 0.03), and Visual Analogue Self-Esteem Scale (P < 0.01). At six months, group alone was a significant predictor of the Stroke Aphasic Depression Questionnaire (P < 0.05), and remained significant when baseline values were controlled for (P = 0.02). Mean Stroke Aphasic Depression Questionnaire 10-item hospital version scores decreased from baseline to six months by six points in the intervention group as compared with an increase of 1.9 points in the control group. Conclusions: Behavioural therapy seemed to improve the mood of people with aphasia

Sub-Nyquist Field Trial Using Time Frequency Packed DP-QPSK Super-Channel Within Fixed ITU-T Grid

Sub-Nyquist time frequency packing technique was demonstrated for the first time in a super channel field trial transmission over long-haul distances. The technique allows a limited spectral occupancy even with low order modulation formats. The transmission was successfully performed on a deployed Australian link between Sydney and Melbourne which included 995 km of uncompensated SMF with coexistent traffic. 40 and 100 Gb/s co-propagating channels were transmitted together with the super-channel in a 50 GHz ITU-T grid without additional penalty. The super-channel consisted of eight sub-channels with low-level modulation format, i.e. DP-QPSK, guaranteeing better OSNR robustness and reduced complexity with respect to higher order formats. At the receiver side, coherent detection was used together with iterative maximum-a-posteriori (MAP) detection and decoding. A 975 Gb/s DP-QPSK super-channel was successfully transmitted between Sydney and Melbourne within four 50GHz WSS channels (200 GHz). A maximum potential SE of 5.58 bit/s/Hz was achieved with an OSNR=15.8 dB, comparable to the OSNR of the installed 100 Gb/s channels. The system reliability was proven through long term measurements. In addition, by closing the link in a loop back configuration, a potential SE*d product of 9254 bit/s/Hz*km was achieved

Distribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms

Selenium is an essential micronutrient for many organisms, and in vertebrates has a variety of roles associated with protection from reactive oxygen species. Over the past two decades there have been conflicting reports upon human health benefits and detriments arising from consumption of selenium dietary supplements. Thus, early studies report a decrease in the incidence of certain types of cancer, whereas subsequent studies did not observe any anti-cancer effect, and adverse effects such as increased risks for type 2 diabetes have been reported. A possible contributing factor may be that different chemical forms of selenium were used in different studies. Using larval stage zebrafish (Danio rerio) as a model organism, we report a comparison of the toxicities and tissue selenium distributions of four different chemical forms of selenium. We find that the organic forms of selenium tested (Se-methyl-l-selenocysteine and l-selenomethionine) show considerably more toxicity than inorganic forms (selenite and selenate), and that this appears to be correlated with the level of bioaccumulation. Despite differences in concentrations, the tissue specific pattern of selenium accumulation was similar for the chemical forms tested; selenium was found to be highly concentrated in pigment (melanin) containing tissues especially for the organic selenium treatments, with lower concentrations in eye lens, yolk sac and heart. These results suggest that pigmented tissues might serve as a storage reservoir for selenium. © 2016 The Royal Society of Chemistry

Chiral Extrapolation of Lattice Data for Heavy Baryons

The masses of heavy baryons containing a b quark have been calculated numerically in lattice QCD with pion masses which are much larger than its physical value. In the present work we extrapolate these lattice data to the physical mass of the pion by applying the effective chiral Lagrangian for heavy baryons, which is invariant under chiral symmetry when the light quark masses go to zero and heavy quark symmetry when the heavy quark masses go to infinity. A phenomenological functional form with three parameters, which has the correct behavior in the chiral limit and appropriate behavior when the pion mass is large, is proposed to extrapolate the lattice data. It is found that the extrapolation deviates noticably from the naive linear extrapolation when the pion mass is smaller than about 500MeV. The mass differences between Sigma_b and Sigma_b^* and between Sigma_b^{(*)} and Lambda_b are also presented. Uncertainties arising from both lattice data and our model parameters are discussed in detail. We also give a comparision of the results in our model with those obtained in the naive linear extrapolations.Comment: 29 pages, 9 figure