Spectrophotometric Determination of Salbutamol Sulphate and Isoxsuprine Hydrochloride in Pharmaceutical Formulations

امكن تطوير طريقة يسيرة وحساسة لتقدير كبريتات السالبيوتامول وايزوكسوبرين هيدروكلوريد بشكلهما النقي وفي مستحضراتهما الصيدلانية, استندت الطريقة على مبدأ اكسدة المركبين الدوائيين بزيادة محسوبة من العامل المؤكسد N- بروموسكسينميد في وسط حامض الهيدروكلوريك وادخال غير المتفاعل من العامل المؤكسد في تفاعل اكسدة صبغة ايفانز الزرقاء المضافة بكمية ثابتة مؤديا الى قصر لونها الازرق وقياس المتبقي من الصبغة عند الطول الموجي 600 نانوميتر, اذ وجد ان امتصاص الصبغه المتبقية يزداد خطيا مع زيادة تركيز المركبين الدوائيين ضمن مدى التراكيز 1-12 و 1-11 مايكروغرام/مللتر بامتصاصية مولارية 4.21×410 و 2.58×410 لتر .مول-1.سم-1 لكل من كبريتات السالبيوتامول وايزوكسوبرين هيدروكلوريد على التوالي. طبقت الطريقة بنجاح على المستحضرات الصيدلانية للمركبين الدوائيين وكانت نتائجها متوافقة مع نتائج طريقة الاضافة القياسية مما يدل على ان الطريقة ذات دقة وصلاحية تطبيق تحليلي جيدة.A simple, sensitive and accurate spectrophotometric method has been developed for the determination of salbutamol sulphate (SAB) and isoxsuprine hydrochloride (ISX) in pure and pharmaceutical dosage. The method involved oxidation of (SAB) and (ISX) with a known excess of N-bromosuccinamid in acidic medium, and subsequent occupation of unreacted oxidant in decolorization of Evans blue dye (EB). This, in the presence of SAB or ISX was rectilinear over the ranges 1.0-12.0, 1.0-11.0 µg/mL, with molar absorptivity 4.21×104 and 2.58×104 l.mol-1.cm-1 respectively. The developed method had been successfully applied for the determination of the studied drugs in their pharmaceutical dosage resulting in a good agreement with certified value and standard addition procedure

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries