Three-Dimensional Tricritical Gravity

We consider a class of parity even, six-derivative gravity theories in three dimensions. After linearizing around anti-de Sitter space, the theories have one massless and two massive graviton solutions for generic values of the parameters. At a special, so-called tricritical, point in parameter space the two massive graviton solutions become massless and they are replaced by two solutions with logarithmic and logarithmic-squared boundary behavior. The theory at this point is conjectured to be dual to a rank-3 Logarithmic Conformal Field Theory (LCFT) whose boundary stress tensor, central charges and new anomaly we calculate. We also calculate the conserved Abbott-Deser-Tekin charges. At the tricritical point, these vanish for excitations that obey Brown-Henneaux and logarithmic boundary conditions, while they are generically non-zero for excitations that show logarithmic-squared boundary behavior. This suggests that a truncation of the tricritical gravity theory and its corresponding dual LCFT can be realized either via boundary conditions on the allowed gravitational excitations, or via restriction to a zero charge sub-sector. We comment on the structure of the truncated theory.Comment: 37 pages, 2 figures; v2: added reference; published versio

Brown Carbon Production by Aqueous-Phase Interactions of Glyoxal and SO2

Oxalic acid and sulfate salts are major components of aerosol particles. Here, we explore the potential for their respective precursor species, glyoxal and SO2, to form atmospheric brown carbon via aqueous-phase reactions in a series of bulk aqueous and flow chamber aerosol experiments. In bulk aqueous solutions, UV- and visible-light-absorbing products are observed at pH 3–4 and 5–6, respectively, with small but detectable yields of hydroxyquinone and polyketone products formed, especially at pH 6. Hydroxymethanesulfonate (HMS), C2, and C3 sulfonates are major products detected by electrospray ionization mass spectrometry (ESI-MS) at pH 5. Past studies have assumed that the reaction of formaldehyde and sulfite was the only atmospheric source of HMS. In flow chamber experiments involving sulfite aerosol and gas-phase glyoxal with only 1 min residence times, significant aerosol growth is observed. Rapid brown carbon formation is seen with aqueous aerosol particles at \u3e80% relative humidity (RH). Brown carbon formation slows at 50–60% RH and when the aerosol particles are acidified with sulfuric acid but stops entirely only under dry conditions. This chemistry may therefore contribute to brown carbon production in cloud-processed pollution plumes as oxidizing volatile organic compounds (VOCs) interact with SO2 and water

Mid-Infrared Properties of Luminous Infrared Galaxies II: Probing the Dust and Gas Physics of the GOALS Sample

The Great Observatories All-Sky LIRG Survey (GOALS) is a comprehensive, multiwavelength study of luminous infrared galaxies (LIRGs) in the local universe. Here we present the results of a multi-component, spectral decomposition analysis of the low resolution mid-IR Spitzer IRS spectra from 5-38um of 244 LIRG nuclei. The detailed fits and high quality spectra allow for characterization of the individual PAH features, warm molecular hydrogen emission, and optical depths for silicate dust grains and water ices. We find that starbursting LIRGs, which make up the majority of GOALS, are very consistent in their MIR properties (i.e. tau_9.7um, tau_ice, neon line and PAH feature ratios). However, as their PAH EQW decreases, usually an indicator of an increasingly dominant AGN, LIRGs cover a larger spread in these MIR parameters. The contribution from PAHs to the total L(IR) in LIRGs varies from 2-29% and LIRGs prior to their first encounter show higher L(PAH)/L(IR) ratios on average. We observe a correlation between the strength of the starburst (IR8) and the PAH fraction at 8um but not with the 7.7 to 11.3 PAH ratio, suggesting the fractional PDR emission, and not the overall grain properties, is associated with the rise in IR8 for galaxies off the starburst main sequence. We detect crystalline silicate features in 6% of the sample but only in the most obscured sources (s_9.7um < -1.24). Ice absorption features are observed in 11% (56%) of GOALS LIRGs (ULIRGs). Most GOALS LIRGs have L(H2)/L(PAH) ratios elevated above those observed for normal star-forming galaxies and exhibit a trend for increasing L(H2)/L(PAH) ratio with increasing L(H2). While star formation appears to be the dominant process responsible for exciting the H2 in most of the GOALS galaxies, a subset of LIRGs (10%) show excess H2 emission that is inconsistent with PDR models and may be excited by shocks or AGN-induced outflows.Comment: 21 pages with 20 figures plus 2 table

A Non-relativistic Logarithmic Conformal Field Theory from a Holographic Point of View

We study a fourth-order derivative scalar field configuration in a fixed Lifshitz background. Using an auxiliary field we rewrite the equations of motion as two coupled second order equations. We specialize to the limit that the mass of the scalar field degenerates with that of the auxiliary field and show that logarithmic modes appear. Using non-relativistic holographic methods we calculate the two-point correlation functions of the boundary operators in this limit and find evidence for a non-relativistic logarithmic conformal field theory at the boundary.Comment: 17 pages, v2 : refs. adde

FRA2A is a CGG repeat expansion associated with silencing of AFF3

Folate-sensitive fragile sites (FSFS) are a rare cytogenetically visible subset of dynamic mutations. Of the eight molecularly characterized FSFS, four are associated with intellectual disability (ID). Cytogenetic expression results from CGG tri-nucleotide-repeat expansion mutation associated with local CpG hypermethylation and transcriptional silencing. The best studied is the FRAXA site in the FMR1 gene, where large expansions cause fragile X syndrome, the most common inherited ID syndrome. Here we studied three families with FRA2A expression at 2q11 associated with a wide spectrum of neurodevelopmental phenotypes. We identified a polymorphic CGG repeat in a conserved, brain-active alternative promoter of the AFF3 gene, an autosomal homolog of the X-linked AFF2/FMR2 gene: Expansion of the AFF2 CGG repeat causes FRAXE ID. We found that FRA2A-expressing individuals have mosaic expansions of the AFF3 CGG repeat in the range of several hundred repeat units. Moreover, bisulfite sequencing and pyrosequencing both suggest AFF3 promoter hypermethylation. cSNP-analysis demonstrates monoallelic expression of the AFF3 gene in FRA2A carriers thus predicting that FRA2A expression results in functional haploinsufficiency for AFF3 at least in a subset of tissues. By whole-mount in situ hybridization the mouse AFF3 ortholog shows strong regional expression in the developing brain, somites and limb buds in 9.5-12.5dpc mouse embryos. Our data suggest that there may be an association between FRA2A and a delay in the acquisition of motor and language skills in the families studied here. However, additional cases are required to firmly establish a causal relationship

Splenectomy Normalizes Hematocrit in Murine Polycythemia Vera

Splenic enlargement (splenomegaly) develops in numerous disease states, although a specific pathogenic role for the spleen has rarely been described. In polycythemia vera (PV), an activating mutation in Janus kinase 2 (JAK2V617) induces splenomegaly and an increase in hematocrit. Splenectomy is sparingly performed in patients with PV, however, due to surgical complications. Thus, the role of the spleen in the pathogenesis of human PV remains unknown. We specifically tested the role of the spleen in the pathogenesis of PV by performing either sham (SH) or splenectomy (SPL) surgeries in a murine model of JAK2V617F-driven PV. Compared to SH-operated mice, which rapidly develop high hematocrits after JAK2V617F transplantation, SPL mice completely fail to develop this phenotype. Disease burden (JAK2V617) is equivalent in the bone marrow of SH and SPL mice, however, and both groups develop fibrosis and osteosclerosis. If SPL is performed after PV is established, hematocrit rapidly declines to normal even though myelofibrosis and osteosclerosis again develop independently in the bone marrow. In contrast, SPL only blunts hematocrit elevation in secondary, erythropoietin-induced polycythemia. We conclude that the spleen is required for an elevated hematocrit in murine, JAK2V617F-driven PV, and propose that this phenotype of PV may require a specific interaction between mutant cells and the spleen

Unitary Truncations and Critical Gravity: a Toy Model

We investigate a higher-derivative scalar field model in a fixed d+1 dimensional AdS background as a toy model for a gravitational dual to a higher-rank logarithmic CFT. The holographic two-point correlation functions on the boundary agree with higher-rank LCFT correlation functions. For odd rank, the theory allows for a truncation to a nontrivial subspace with non-negative scalar product. We discuss possible implications for higher-derivative critical gravity theories.Comment: 23 pages. As accepted for publication in JHE

Single-nucleotide polymorphism associations with preterm delivery: a case-control replication study and meta-analysis

BackgroundThe aim of this study was to replicate single-nucleotide polymorphism (SNP) associations with preterm birth (PTB; birth at MethodsSpontaneous PTB cases and controls were selected from an existing cohort. Candidate SNPs were taken from an existing genotype panel. A systematic review was conducted for each SNP in the panel to determine suitability as a PTB candidate. Those with significant associations previously reported in Caucasians were selected for replication. Candidate SNPs were already genotyped in cases and controls and clinical data were accessed from state perinatal and cerebral palsy databases. Association analysis was conducted between each SNP and PTB, and meta-analysis was conducted if there were ≥ 3 studies in the literature. Maternal and fetal SNPs were considered as separate candidates.ResultsA cohort of 170 cases and 583 controls was formed. Eight SNPs from the original panel of genotyped SNPs were selected as PTB candidates and for replication on the basis of systematic literature review results. In our cohort, fetal factor V Leiden (FVL) was significantly associated with PTB (odds ratio (OR): 2.6, 95% confidence interval (CI): 1.31-5.17), and meta-analysis confirmed this association (OR: 2.71, 95% CI: 1.15-6.4).ConclusionReplication and meta-analysis support an increased risk of PTB in Caucasians with the fetal FVL mutation.Michael E. O’Callaghan, Alastair H. MacLennan, Gai L. McMichael, Eric A. Haan and Gustaaf A. Dekke