CMI analysis and precoding designs for correlated multi-hop MIMO channels

Conditional mutual information (CMI) analysis and precoding design for generally correlated wireless multi-hop multi-input multi-output (MIMO) channels are presented in this paper. Although some particular scenarios have been examined in existing publications, this paper investigates a generally correlated transmission system having spatially correlated channel, mutually correlated source symbols, and additive colored Gaussian noise (ACGN). First, without precoding techniques, we derive the optimized source symbol covariances upon mutual information maximization. Secondly, we apply a precoding technique and then design the precoder in two cases: maximizing the mutual information and minimizing the detection error. Since the optimal design for the end-to-end system cannot be analytically obtained in closed form due to the non-monotonic nature, we relax the optimization problem and attain sub-optimal designs in closed form. Simulation results show that without precoding, the average mutual information obtained by the asymptotic design is very close to the one obtained by the optimal design, while saving a huge computational complexity. When having the proposed precoding matrices, the end-to-end mutual information significantly increases while it does not require resources of the system such as transmission power or bandwidth

Noncoherent Receiver for Decode-and-Forward Cooperative Systems with Multi-Antenna Equipped Destination

This paper studies a maximum energy selection receiver for an adaptive decode-and-forward (DF) cooperative wireless system with multiple-antenna equipped destination. In particular, the destination selects the maximum output from all the outputs of the square-law detectors to perform the detection of the transmitted information. A close-form expression for the bit-error-rate (BER) is analytically derived when the system is deployed with binary frequency-shift keying (BFSK) modulation. The thresholds used at the relays to address the issue of error propagation are optimized to minimize the BER. While finding the optimal thresholds requires information on the average signal-to-noise ratios (SNRs) of all the transmission links in the system, the approximate thresholds at each relay that require only information on the average SNR of the source-corresponding relay are investigated. It is also derived that the system achieves a full diversity order with the approximate thresholds. Finally, both analytical and simulation results are provided to verify our analysis

Asynchronous Sampling Rate Conversions in Digital Communications Systems

The problem of resampling digital signals at an output sampling rate that is incommensurate with the input sampling rate is the topic of this paper. This problem is often encountered in practice, as for example in the multiplexing of video signals from different sources for the purpose of distribution. There are basically two approaches to resample the signals. Both approaches are thoroughly described and practical circuits for hardware implementation are provided. A comparison of the two circuits presented in the paper shows that one circuit requires a division to compute the new sampling times. This time scaling operation adds complexity to the implementation with no performance advantage over the other circuit, and makes the “division free” circuit the preferred one for resampling

Conformational Instability of Rodlike Polyelectrolytes due to Counterion Fluctuations

The effective elasticity of highly charged stiff polyelectrolytes is studied in the presence of counterions, with and without added salt. The rigid polymer conformations may become unstable due to an effective attraction induced by counterion density fluctuations. Instabilities at the longest, or intermediate length scales may signal collapse to globule, or necklace states, respectively. In the presence of added-salt, a generalized electrostatic persistence length is obtained, which has a nontrivial dependence on the Debye screening length. It is also found that the onset of conformational instability is a re-entrant phenomenon as a function of polyelectrolyte length for the unscreened case, and the Debye length or salt concentration for the screened case. This may be relevant in understanding the experimentally observed re-entrant condensation of DNA.Comment: 8 pages, 4 figure

Design of Experiments for Screening

The aim of this paper is to review methods of designing screening experiments, ranging from designs originally developed for physical experiments to those especially tailored to experiments on numerical models. The strengths and weaknesses of the various designs for screening variables in numerical models are discussed. First, classes of factorial designs for experiments to estimate main effects and interactions through a linear statistical model are described, specifically regular and nonregular fractional factorial designs, supersaturated designs and systematic fractional replicate designs. Generic issues of aliasing, bias and cancellation of factorial effects are discussed. Second, group screening experiments are considered including factorial group screening and sequential bifurcation. Third, random sampling plans are discussed including Latin hypercube sampling and sampling plans to estimate elementary effects. Fourth, a variety of modelling methods commonly employed with screening designs are briefly described. Finally, a novel study demonstrates six screening methods on two frequently-used exemplars, and their performances are compared

Severe Pandemic H1N1 2009 Infection Is Associated with Transient NK and T Deficiency and Aberrant CD8 Responses

BACKGROUND: It is unclear why the severity of influenza varies in healthy adults or why the burden of severe influenza shifts to young adults when pandemic strains emerge. One possibility is that cross-protective T cell responses wane in this age group in the absence of recent infection. We therefore compared the acute cellular immune response in previously healthy adults with severe versus mild pandemic H1N1 infection. METHODS AND PRINCIPAL FINDINGS: 49 previously healthy adults admitted to the National Hospital of Tropical Diseases, Viet Nam with RT-PCR-confirmed 2009 H1N1 infection were prospectively enrolled. 39 recovered quickly whereas 10 developed severe symptoms requiring supplemental oxygen and prolonged hospitalization. Peripheral blood lymphocyte subset counts and activation (HLADR, CD38) and differentiation (CD27, CD28) marker expression were determined on days 0, 2, 5, 10, 14 and 28 by flow cytometry. NK, CD4 and CD8 lymphopenia developed in 100%, 90% and 60% of severe cases versus 13% (p<0.001), 28%, (p = 0.001) and 18% (p = 0.014) of mild cases. CD4 and NK counts normalized following recovery. B cell counts were not significantly associated with severity. CD8 activation peaked 6-8 days after mild influenza onset, when 13% (6-22%) were HLADR+CD38+, and was accompanied by a significant loss of resting/CD27+CD28+ cells without accumulation of CD27+CD28- or CD27-CD28- cells. In severe influenza CD8 activation peaked more than 9 days post-onset, and/or was excessive (30-90% HLADR+CD38+) in association with accumulation of CD27+CD28- cells and maintenance of CD8 counts. CONCLUSION: Severe influenza is associated with transient T and NK cell deficiency. CD8 phenotype changes during mild influenza are consistent with a rapidly resolving memory response whereas in severe influenza activation is either delayed or excessive, and partially differentiated cells accumulate within blood indicating that recruitment of effector cells to the lung could be impaired