Fourier domain mode locking laser sweeping based on optical parametric amplification

We present a Fourier domain mode locked (FDML) laser scanning from 1516 to 1550 nm and 1567 to 1597 nm using optical parametric amplifier (OPA) as the gain medium. The output power of -4.85 dBm with sweep rate of 39.6 kHz is achieved. © 2010 IEEE.published_or_final_versionThe 2010 Conference on Optical Fiber Communication (OFC), collocated National Fiber Optic Engineers Conference (OFC/NFOEC), San Diego, CA., 21-25 March 2010. In Proceedings of OFC/NFOEC, 2010, p. 1-

Self-Protection of Electrochemical Storage Devices via a Thermal Reversible Sol-Gel Transition

Thermal self-protected intelligent electrochemical storage devices are fabricated using a reversible sol–gel transition of the electrolyte, which can decrease the specific capacitance and increase and enable temperature-dependent charging and discharging rates in the device. This work represents proof of a simple and useful concept, which shows tremendous promise for the safe and controlled power delivery in electrochemical devices.NRF (Natl Research Foundation, S’pore

The discovery and development of Eg5 inhibitors for the clinic

The mitotic kinesin Eg5 (also known as kinesin spindle protein, KSP, Kif11, a member of the kinesin-5 family) represents an attractive oncology drug target in the ongoing development of anti-mitotic drugs that selectively block mitosis through disruption to the mitotic spindle. In this state-of-the-art review, we outline the progress that has been made in the development of Eg5 inhibitors for clinical use. We evaluate the preclinical development and attributes of key Eg5 inhibitors that have undergone clinical evaluation or extensive preclinical optimisation, and discuss the medicinal chemistry strategies utilised in their design to overcome the challenges encountered during lead optimisation. We critically analyse the progress that has been made towards delivering clinical benefits, and the wider implications this has in the utility of mitotic kinesin inhibitors as prospective oncology drugs

Observation System for Analyzing Individual Boccia BC3

Boccia is a Paralympic sport for athletes with locomotor dysfunction. The aim of this observational methodology study was to describe the design of an ad hoc observation instrument for analyzing individual boccia in the BC3 category (for athletes with severe functional impairment) and to show how it can be used in a practical setting to analyze technical and tactical aspects of the game. The observation instrument was designed based on the internal logic and rules of boccia and was then loaded into the Lince software program to create a simple coding tool. The content of the instrument was validated by a panel of experts with extensive experience in Paralympic boccia. The reliability of the resulting data was confirmed by analysis of interobserver agreement, with high kappa values obtained for all criteria. The practical application of the observation system was demonstrated by performing T-pattern analysis of two sample datasets, which revealed underlying behavioral patterns for isolated throws (synchronic) and successive throws (diachronic)