Factor ordering in standard quantum cosmology

The Wheeler-DeWitt equation of Friedmann models with a massless quantum field is formulated with arbitrary factor ordering of the Hamiltonian constraint operator. A scalar product of wave functions is constructed, giving rise to a probability interpretation and making comparison with the classical solution possible. In general the bahaviour of the wave function of the model depends on a critical energy of the matter field, which, in turn, depends on the chosen factor ordering. By certain choices of the ordering the critical energy can be pushed down to zero.Comment: 15 pages, 3 figure

On plane gravitational waves in real connection variables

We investigate using plane fronted gravitational wave space-times as model systems to study loop quantization techniques and dispersion relations. In this classical analysis, we start with planar symmetric space-times in the real connection formulation. We reduce via Dirac constraint analysis to a final form with one canonical pair and one constraint, equivalent to the metric and Einstein equations of plane-fronted with parallel rays waves. Due to the symmetries and use of special coordinates general covariance is broken. However, this allows us to simply express the constraints of the consistent system. A recursive construction of Dirac brackets results in non-local brackets, analogous to those of self-dual fields, for the triad variables chosen in this approach.Comment: v2: Matches published version, up to minor stylistic change

Towards Loop Quantization of Plane Gravitational Waves

The polarized Gowdy model in terms of Ashtekar-Barbero variables is further reduced by including the Killing equations for plane-fronted parallel gravitational waves with parallel rays. The resulting constraint algebra, including one constraint derived from the Killing equations in addition to the standard ones of General Relativity, are shown to form a set of first-class constraints. Using earlier work by Banerjee and Date the constraints are expressed in terms of classical quantities that have an operator equivalent in Loop Quantum Gravity, making space-times with pp-waves accessible to loop quantization techniques.Comment: 14 page

Isotropic Loop Quantum Cosmology with Matter

A free massless scalar field is coupled to homogeneous and isotropic loop quantum cosmology. The coupled model is investigated in the vicinity of the classical singularity, where discreteness is essential and where the quantum model is non-singular, as well as in the regime of large volumes, where it displays the expected semiclassical features. The particular matter content (massless, free scalar) is chosen to illustrate how the discrete structure regulates pathological behavior caused by kinetic terms of matter Hamiltonians (which in standard quantum cosmology lead to wave functions with an infinite number of oscillations near the classical singularity). Due to this modification of the small volume behavior the dynamical initial conditions of loop quantum cosmology are seen to provide a meaningful generalization of DeWitt's initial condition.Comment: 18 pages, 4 figure

Wavelength-selected Neutron Pulses Formed by a Spatial Magnetic Neutron Spin Resonator

AbstractWe present a novel type of spatial magnetic neutron spin resonator whose time and wavelength resolution can be de- coupled from each other by means of a travelling wave mode of operation. Combined with a pair of highly efficient polarisers such a device could act simultaneously as monochromator and chopper, able to produce short neutron pulses, whose wavelength, spectral width and duration could be varied almost instantaneously by purely electronic means with- out any mechanical modification of the experimental setup. To demonstrate the practical feasibility of this technique we have designed and built a first prototype resonator consisting of ten individually switchable modules which allows to produce neutron pulses in the microsecond regime. It was installed at a polarised 2.6Å neutron beamline at the 250kW TRIGA research reactor of the Vienna University of Technology where it could deliver pulses of 55μs duration, which is about three times less than the passage time of the neutrons through the resonator itself. In order to further improve the achievable wavelength resolution to about 3% a second prototype resonator, consisting of 48 individual modules with optimised field homogeneity and enlarged beam cross-section of 6 × 6cm2 was developed. We present the results of first measurements which demonstrate the successful operation of this device

Inhibition of NK Reactivity Against Solid Tumors by Platelet-Derived RANKL.

NK cells play an important role in tumor immunosurveillance. Their reactivity is governed by various activating and inhibitory surface receptors, which include several members of the TNF/TNF receptor family. For more than 50 years, it has been recognized that tumor immunosurveillance and in particular NK cell antitumor reactivity is largely influenced by platelets, but the underlying mechanisms remain to be fully elucidated. Here we report that upon activation, which reportedly occurs following interaction with cancer cells, platelets upregulate the TNF family member RANKL. Comparative analysis of the expression of RANK among different NK cell subsets and RANKL on platelets in cancer patients and healthy volunteers revealed a distinct malignant phenotype, and platelet-derived RANKL was found to inhibit the activity of normal NK cells against cancer cells. Notably, NK cell antitumor reactivity could be partially restored by application of denosumab, a RANKL-neutralizing antibody approved for treatment of benign and malignant osteolysis. Together, our data not only unravel a novel mechanism of tumor immune evasion mediated by platelets, but they also provide a functional explanation for the clinical observation that denosumab, beyond protecting from bone loss, may prolong disease-free survival in patients with solid tumors

States insensitive to the Unruh effect in multi-level detectors

We give a general treatment of the spontaneous excitation rates and the non-relativistic Lamb shift of constantly accelerated multi-level atoms as a model for multi-level detectors. Using a covariant formulation of the dipole coupling between the atom and the electromagnetic field we show that new Raman-like transitions can be induced by the acceleration. Under certain conditions these transitions can lead to stable ground and excited states which are not affected by the non inertial motion. The magnitude of the Unruh effect is not altered by multi-level effects. Both the spontaneous excitation rates and the Lamb shift are not within the range of measurability.Comment: 9 Pages, late

From Vacuum Fluctuations to Radiation: Accelerated Detectors and Black Holes

The vacuum fluctuations that induce the transitions and the thermalisation of a uniformly accelerated two level atom are studied in detail. Their energy content is revealed through the weak measurement formalism of Aharonov et al. It is shown that each time the detector makes a transition it radiates a Minkowski photon. The same analysis is then applied to the conversion of vacuum fluctuations into real quanta in the context of black hole radiation. Initially these fluctuations are located around the light like geodesic that shall generate the horizon and carry zero total energy. However upon exiting from the star they break up into two pieces one of which gradually acquires positive energy and becomes a Hawking quantum, the other, its ''partner", ends up in the singularity. As time goes by the vacuum fluctuations generating Hawking quanta have exponentially large energy densities. This implies that back reaction effects are large.Comment: definitive version, 39 pages and 5 figures available upon request from S.M., ULB-TH 94/0

Interaction of Hawking radiation with static sources outside a Schwarzschild black hole

We show that the response rate of (i) a static source interacting with Hawking radiation of massless scalar field in Schwarzschild spacetime (with the Unruh vacuum) and that of (ii) a uniformly accelerated source with the same proper acceleration in Minkowski spacetime (with the Minkowski vacuum) are equal. We show that this equality will not hold if the Unruh vacuum is replaced by the Hartle-Hawking vacuum. It is verified that the source responds to the Hawking radiation near the horizon as if it were at rest in a thermal bath in Minkowski spacetime with the same temperature. It is also verified that the response rate in the Hartle-Hawking vacuum approaches that in Minkowski spacetime with the same temperature far away from the black hole. Finally, we compare our results with others in the literature.Comment: 18 pages (REVTEX

Loop Quantum Cosmology

Quantum gravity is expected to be necessary in order to understand situations where classical general relativity breaks down. In particular in cosmology one has to deal with initial singularities, i.e. the fact that the backward evolution of a classical space-time inevitably comes to an end after a finite amount of proper time. This presents a breakdown of the classical picture and requires an extended theory for a meaningful description. Since small length scales and high curvatures are involved, quantum effects must play a role. Not only the singularity itself but also the surrounding space-time is then modified. One particular realization is loop quantum cosmology, an application of loop quantum gravity to homogeneous systems, which removes classical singularities. Its implications can be studied at different levels. Main effects are introduced into effective classical equations which allow to avoid interpretational problems of quantum theory. They give rise to new kinds of early universe phenomenology with applications to inflation and cyclic models. To resolve classical singularities and to understand the structure of geometry around them, the quantum description is necessary. Classical evolution is then replaced by a difference equation for a wave function which allows to extend space-time beyond classical singularities. One main question is how these homogeneous scenarios are related to full loop quantum gravity, which can be dealt with at the level of distributional symmetric states. Finally, the new structure of space-time arising in loop quantum gravity and its application to cosmology sheds new light on more general issues such as time.Comment: 104 pages, 10 figures; online version, containing 6 movies, available at http://relativity.livingreviews.org/Articles/lrr-2005-11