The neurological manifestations of trauma: lessons from World War I

Changes in the clinical presentation of functional disorders and the influence of social and cultural factors can be investigated through the historical case notes from mental hospitals. World War I (WWI) was a potent trigger of functional disorders with neurological or psychiatric symptoms. We analysed 100 randomly selected case files of German servicemen admitted to the Department of Psychiatry of the Charité Medical School of Berlin University during WWI and classified them according to contemporaneous and retrospective modern diagnoses. We compared the clinical presentations with accounts in the German and British medical literature of the time. Most patients obtained the contemporaneous diagnosis of ‘psychopathic constitution’ or hysteria reflecting the general view of German psychiatrists that not the war but an individual predisposition was the basis for the development of symptoms. The clinical picture was dominated by pseudoneurological motor or sensory symptoms as well as pseudoseizures. Some soldiers relived combat experiences in dream-like dissociative states that partly resemble modern-day post-traumatic stress disorder. Most servicemen were classified as unfit for military service but very few of them were granted compensation. Severe functional disorders of a neurological character could develop even without traumatic exposure in combat, which is of interest for the current debate on triggers of stress disorders. The high incidence of pseudoseizures accords with the psychiatric literature of the time and contrasts with accounts of war-related disorders in Britain. The tendency of German psychiatrists not to send traumatised servicemen back to active duty also distinguished between German and British practice. Our data contribute to the debate on the changing patterns of human responses to traumatic experience and their historical and social context

Prosodic modules for speech recognition and understanding in VERBMOBIL

Within VERBMOBIL, a large project on spoken language research in Germany, two modules for detecting and recognizing prosodic events have been developed. One module operates on speech signal parameters and the word hypothesis graph, whereas the other module, designed for a novel, highly interactive architecture, only uses speech signal parameters as its input. Phrase boundaries, sentence modality, and accents are detected. The recognition rates in spontaneous dialogs are for accents up to 82,5%, for phrase boundaries up to 91,7%

At home with users: a comparative view of living labs

Living Labs provide a ‘human-centric’ research approach for the design of new ICT artefacts. In Living Labs users participate over several design stages, providing insights into unexpected ICT use, co-creation and evaluation of new IT solutions. Although this approach is becoming more popular, there is little comparative and reflective work on its practical dynamics, problems and possibilities. In this study, we analyse two 4-year Living Lab projects in Lancaster, UK and Siegen, Germany within the domain of Social TV, and compare experiences. We focus on documenting the purposes, methods and user dynamics that affect the trajectory of such long-term research initiatives, focusing inter alia on the dynamics of researcher/user interaction and the developing issues of trust and managing expectations; emphasizing some often neglected ethical issues and the impact of users' individual characteristics and their role in the community dynamics of Living Labs

Der Mensch im Experiment:1850-1980

Im Zuge der laboratory revolution wurde der Mensch »Gegenstand« experimenteller Praktiken und wissenschaftlicher Versuchsmethoden. Die Tagung versucht, das Experimentieren am Menschen in seiner für die modernen Lebenswissenschaften konstitutiven Figuration einer historischen und epistemologischen Reflektion zu unterziehen. Dabei soll die starre, oft normative gesetzte Ordnung zwischen »Humanexperiment« einerseits und »Heilversuch« andererseits, zwischen »ethisch verwerflichen« und »moralisch akzeptablen« Menschenversuch aufgebrochen werden. Anhand von Fallbeispielen aus den verschiedensten Disziplinen und geographischen Räumen soll der Status des Menschen als Erkenntnisort im Selbst-, Impf- und Arzneimittelversuch diskutiert werden.Der Mensch im Experiment: 1850-1980, conference, ICI Berlin, 22 May 2008 <https://doi.org/10.25620/e080522

The neurosurgical benefit of contactless in vivo optical coherence tomography regarding residual tumor detection: A clinical study

PurposeIn brain tumor surgery, it is crucial to achieve complete tumor resection while conserving adjacent noncancerous brain tissue. Several groups have demonstrated that optical coherence tomography (OCT) has the potential of identifying tumorous brain tissue. However, there is little evidence on human in vivo application of this technology, especially regarding applicability and accuracy of residual tumor detection (RTD). In this study, we execute a systematic analysis of a microscope integrated OCT-system for this purpose.Experimental designMultiple 3-dimensional in vivo OCT-scans were taken at protocol-defined sites at the resection edge in 21 brain tumor patients. The system was evaluated for its intraoperative applicability. Tissue biopsies were obtained at these locations, labeled by a neuropathologist and used as ground truth for further analysis. OCT-scans were visually assessed with a qualitative classifier, optical OCT-properties were obtained and two artificial intelligence (AI)-assisted methods were used for automated scan classification. All approaches were investigated for accuracy of RTD and compared to common techniques.ResultsVisual OCT-scan classification correlated well with histopathological findings. Classification with measured OCT image-properties achieved a balanced accuracy of 85%. A neuronal network approach for scan feature recognition achieved 82% and an auto-encoder approach 85% balanced accuracy. Overall applicability showed need for improvement.ConclusionContactless in vivo OCT scanning has shown to achieve high values of accuracy for RTD, supporting what has well been described for ex vivo OCT brain tumor scanning, complementing current intraoperative techniques and even exceeding them in accuracy, while not yet in applicability