The role of facial movements in emotion recognition

Most past research on emotion recognition has used photographs of posed expressions intended to depict the apex of the emotional display. Although these studies have provided important insights into how emotions are perceived in the face, they necessarily leave out any role of dynamic information. In this Review, we synthesize evidence from vision science, affective science and neuroscience to ask when, how and why dynamic information contributes to emotion recognition, beyond the information conveyed in static images. Dynamic displays offer distinctive temporal information such as the direction, quality and speed of movement, which recruit higher-level cognitive processes and support social and emotional inferences that enhance judgements of facial affect. The positive influence of dynamic information on emotion recognition is most evident in suboptimal conditions when observers are impaired and/or facial expressions are degraded or subtle. Dynamic displays further recruit early attentional and motivational resources in the perceiver, facilitating the prompt detection and prediction of others’ emotional states, with benefits for social interaction. Finally, because emotions can be expressed in various modalities, we examine the multimodal integration of dynamic and static cues across different channels, and conclude with suggestions for future research

Dual-specificity protein phosphatase-1 positively regulates the anti-mycobacterial responses

Posters: abstract no. 214Tuberculosis is still prevalent around world. It is caused by Mycobacterium tuberculosis (Mtb). This microbe stimulates monocytes/macrophages leading to the production of specific cytokines for initiating immune responses. Of these cytokines, tumour necrosis factor-alpha (TNF-α) is crucial for inducing the granuloma formation for restricting Mtb dissemination. Using Bacillus Calmette Guerin (BCG) as a model, we showed ...postprintThe 1st Lorne Infection and Immunity Conference, Lorne, Australia, February 2011. In Abstract Book of the 1st Lorne Infection and Immunity Conference, 2011, p. 111, abstract no. 21

Effect of base–acid properties of the mixtures of water with methanol on the solution enthalpy of selected cyclic ethers in this mixture at 298.15 K

The enthalpies of solution of cyclic ethers: 1,4- dioxane, 12-crown-4 and 18-crown-6 in the mixture of water and methanol have been measured within the whole mole fraction range at T = 298.15 K. Based on the obtained data, the effect of base–acid properties of water– methanol mixtures on the solution enthalpy of cyclic ethers in these mixtures has been analyzed. The solution enthalpy of cyclic ethers depends on acid properties of water– methanol mixtures in the range of high and medium water contents in the mixture. Based on the analysis performed, it can be assumed that in the mixtures of high methanol contents, cyclic ethe

Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCF^Slmb degron

Spinal muscular atrophy (SMA) is caused by homozygous mutations in human SMN1. Expression of a duplicate gene (SMN2) primarily results in skipping of exon 7 and production of an unstable protein isoform, SMNΔ7. Although SMN2 exon skipping is the principal contributor to SMA severity, mechanisms governing stability of survival motor neuron (SMN) isoforms are poorly understood. We used a Drosophila model system and label-free proteomics to identify the SCFSlmb ubiquitin E3 ligase complex as a novel SMN binding partner. SCFSlmb interacts with a phosphor degron embedded within the human and fruitfly SMN YG-box oligomerization domains. Substitution of a conserved serine (S270A) interferes with SCFSlmb binding and stabilizes SMNΔ7. SMA-causing missense mutations that block multimerization of full-length SMN are also stabilized in the degron mutant background. Overexpression of SMNΔ7S270A, but not wild-type (WT) SMNΔ7, provides a protective effect in SMA model mice and human motor neuron cell culture systems. Our findings support a model wherein the degron is exposed when SMN is monomeric and sequestered when SMN forms higher-order multimers

Keys to success of a community of clinical practice in primary care : a qualitative evaluation of the ECOPIH project

The current reality of primary care (PC) makes it essential to have telemedicine systems available to facilitate communication between care levels. Communities of practice have great potential in terms of care and education, and that is why the Online Communication Tool between Primary and Hospital Care was created. This tool enables PC and non-GP specialist care (SC) professionals to raise clinical cases for consultation and to share information. The objective of this article is to explore healthcare professionals' views on communities of clinical practice (CoCPs) and the changes that need to be made in an uncontrolled real-life setting after more than two years of use. A descriptive-interpretative qualitative study was conducted on a total of 29 healthcare professionals who were users and non-users of a CoCP using 2 focus groups, 3 triangular groups and 5 individual interviews. There were 18 women, 21 physicians and 8 nurses. Of the interviewees, 21 were PC professionals, 24 were users of a CoCP and 7 held managerial positions. For a system of communication between PC and SC to become a tool that is habitually used and very useful, the interviewees considered that it would have to be able to find quick, effective solutions to the queries raised, based on up-to-date information that is directly applicable to daily clinical practice. Contact should be virtual - and probably collaborative - via a platform integrated into their habitual workstations and led by PC professionals. Organisational changes should be implemented to enable users to have more time in their working day to spend on the tool, and professionals should have a proactive attitude in order to make the most if its potential. It is also important to make certain technological changes, basically aimed at improving the tool's accessibility, by integrating it into habitual clinical workstations. The collaborative tool that provides reliable, up-to-date information that is highly transferrable to clinical practice is valued for its effectiveness, efficiency and educational capacity. In order to make the most of its potential in terms of care and education, organisational changes and techniques are required to foster greater use. The online version of this article (10.1186/s12875-018-0739-0) contains supplementary material, which is available to authorized users