Review

Mitochondria are the main suppliers of neuronal adenosine triphosphate and play a critical role in brain energy metabolism. Mitochondria also serve as Ca2+ sinks and anabolic factories and are therefore essential for neuronal function and survival. Dysregulation of neuronal bioenergetics is increasingly implicated in neurodegenerative disorders, particularly Parkinson's disease. This review describes the role of mitochondria in energy metabolism under resting conditions and during synaptic transmission, and presents evidence for the contribution of neuronal mitochondrial dysfunction to Parkinson's disease

The Endoplasmic Reticulum Stress Response in Neuroprogressive Diseases: Emerging Pathophysiological Role and Translational Implications

The endoplasmic reticulum (ER) is the main cellular organelle involved in protein synthesis, assembly and secretion. Accumulating evidence shows that across several neurodegenerative and neuroprogressive diseases, ER stress ensues, which is accompanied by over-activation of the unfolded protein response (UPR). Although the UPR could initially serve adaptive purposes in conditions associated with higher cellular demands and after exposure to a range of pathophysiological insults, over time the UPR may become detrimental, thus contributing to neuroprogression. Herein, we propose that immune-inflammatory, neuro-oxidative, neuro-nitrosative, as well as mitochondrial pathways may reciprocally interact with aberrations in UPR pathways. Furthermore, ER stress may contribute to a deregulation in calcium homoeostasis. The common denominator of these pathways is a decrease in neuronal resilience, synaptic dysfunction and even cell death. This review also discusses how mechanisms related to ER stress could be explored as a source for novel therapeutic targets for neurodegenerative and neuroprogressive diseases. The design of randomised controlled trials testing compounds that target aberrant UPR-related pathways within the emerging framework of precision psychiatry is warranted

Radioimmunoassay of Human Serum Serotonin

Peer Reviewe

Entwicklung einer Wiederaufbereitungsanlage fuer kontaminierte Boeden Abschlussbericht

SIGLEAvailable from TIB Hannover: F96B1373 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany); Senatsverwaltung fuer Wissenschaft und Forschung, Berlin (Germany)DEGerman

Wiederaufbereitungsanlage fuer kontaminierte Boeden. Laborphase Abschlussbericht

Available from TIB Hannover: F96B1372 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany); Senatsverwaltung fuer Wissenschaft und Forschung, Berlin (Germany)DEGerman

Ermittlung des Standes der Technik sowie des Standes der Entwicklung auf dem Gebiet der Sanierungstechnologie unter besonderer Beruecksichtigung von kompatiblen Technologien, die eine Verfahrenskombination mit der Harbauer Technologie zulassen in den Vereinigten Staaten von Amerika Schlussbericht

In connection with the development of a wet-mechanical sanitation technology for contaminated soils by the firm Harbauer (FRG) a study has been performed on the state of the art in the field of thermal and chemical/physical processes for the treatment of contaminated materials in the USA. Altogether 37 technologies have been analyzed and 9 technologies are described in detail: ARC/EPRI process for clean-up of contaminated soils, BioTrol soil washing system, TRUclean process for decontaminating radioactive and hazardous soils, US EPA's mobile volume reduction unit for soil washing, Debris washing system, Freeze crystallization process, extraction with liquid gases, X-TRAX"T"M low-temperature thermal desorption, low temperature thermal treatment LT"3. As truly innovative technologies have been ascertained: Freeze crystallization process, extraction with liquid gases, X-TRAX"T"M low-temperature thermal desorption. (WEN)SIGLEAvailable from TIB Hannover: F96B1374 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany); Senatsverwaltung fuer Wissenschaft und Forschung, Berlin (Germany)DEGerman