マウスとウシの脂肪蓄積におけるAdipogeninの役割に関する研究

要約のみTohoku University盧尚建課

Optimising material procurement for construction waste minimization: An exploration of success factors

Although construction waste occurs during the actual construction activities, there is an understanding that it is caused by activities and actions at design, materials procurement and construction stages of project delivery processes. This study investigates the material procurement and logistics measures for mitigating waste generated by construction activities. In a bid to explore the phenomenon from the perspectives of experts from the construction industry, this study used a combination of descriptive interpretive research and survey approach as its methodological framework. The study suggests that four features characterised waste efficient logistic and procurement process. These include suppliers' commitment to low waste measures, low waste purchase management, effective materials delivery management and waste efficient Bill of Quantity. In addition, the key requisite strategies for mitigating construction waste through materials procurement include commitment to take back scheme , procurement of waste efficient materials/technology and use of minimal packaging. The use of Just-in-Time (JIT) delivery system and prevention of over ordering are also important for mitigating waste through materials procurement processes. These implies that while the key measures are critical success factors for reducing waste through procurement process, the four established features are required of all procurement process. Measures through which the procurement process could enhance waste efficiency are further highlighted and discussed in the paper. Findings of this study could assist in understanding a set of measures that should be taken during materials procurement process, thereby corroborating waste management practices at design and construction stages of project delivery process

A framework for big data analytics approach to failure prediction of construction firms

This study explored use of big data analytics (BDA) to analyse data of a large number of construction firms to develop a construction business failure prediction model (CB-FPM). Careful analysis of literature revealed financial ratios as the best form of variable for this problem. Because of MapReduce’s unsuitability for iteration problems involved in developing CB-FPMs, various BDA initiatives for iteration problems were identified. A BDA framework for developing CB-FPM was proposed. It was validated by using 150,000 datacells of 30,000 construction firms, artificial neural network, Amazon Elastic Compute Cloud, Apache Spark and the R software. The BDA CB-FPM was developed in eight seconds while the same process without BDA was aborted after nine hours without success. This shows the issue of not wanting to use large dataset to develop CB-FPM due to tedious duration is resolvable by applying BDA technique. The BDA CB-FPM largely outperformed an ordinary CB-FPM developed with a dataset of 200 construction firms, proving that use of larger sample size with the aid of BDA, leads to better performing CB-FPMs. The high financial and social cost associated with misclassifications (i.e. model error) thus makes adoption of BDA CB-FPMs very important for, among others, financiers, clients and policy maker

Waste effectiveness of the construction industry: Understanding the impediments and requisites for improvements

© 2015 Elsevier B.V. All rights reserved.Construction industry contributes a large portion of waste to landfill, which in turns results in environmental pollution and CO2 emission. Despite the adoption of several waste management strategies, waste reduction to landfill continues seeming an insurmountable challenge. This paper explores factors impeding the effectiveness of existing waste management strategies, as well as strategies for reducing waste intensiveness of the construction industry. Drawing on series of semi structured focus group discussions with experts from the UK leading construction companies, this paper combines phenomenological approach with a critical review and analysis of extant literatures. Five broad categories of factors and practices are responsible for ineffectiveness of construction and demolition waste management strategies, which subsequently results in waste intensiveness of the industry. These include end of pipe treatment of waste, externality and incompatibility of waste management tools with design tools, atomism of waste management strategies, perceived or unexpected high cost of waste management, and culture of waste behaviour within the industry. To reduce waste intensiveness of the construction industry, the study suggests that six factors are requisites. These are tackling of waste at design stage, whole life waste consideration, compliance of waste management solutions with BIM, cheaper cost of waste management practice, increased stringency of waste management legislation and fiscal policies, and research and enlightenment. The proposed strategies are not only important for achieving low waste construction projects, they are important for reducing waste intensiveness of the construction. Implementation of the suggested measures would drive waste management practices within the construction industry

Effects of Glycyrrhizic Acid on Peroxisome Proliferator-Activated Receptor Gamma (PPARγ), Lipoprotein Lipase (LPL), Serum Lipid and HOMA-IR in Rats

Studies on ligand binding potential of glycyrrhizic acid, a potential agonist to PPARγ, displayed encouraging results in amelioration of metabolic syndrome. The regulation of gene cassettes by PPARγ affects glucose homeostasis, lipid, lipoprotein metabolism and adipogenesis. This study was performed to determine the effects of GA on total PPARγ and LPL expression levels, lipid parameters and HOMA-IR. Oral administration of 100 mg/kg GA for 24 hours resulted in an increase in insulin sensitivity with decreases in blood glucose, serum insulin and HOMA-IR. Improvement in serum lipid parameters was also observed with a decrease in triacylglycerol, total cholesterol and LDL-cholesterol and an elevation in HDL-cholesterol. GA administration also resulted in up-regulation of total PPARγ and LPL expression levels in the visceral and subcutaneous adipose tissues, abdominal and quadriceps femoris muscles, as well as liver and kidney, with a significant up-regulation only in the visceral adipose tissue, abdominal and quadriceps femoris muscles. Thus, oral administration of 100 mg/kg GA for 24 hours improved insulin sensitivity and lipid profiles and induced upregulation of total PPARγ and LPL expression levels in all studied tissues

Effects of muscular response for the intensity of vibratory stimulus applied on the ankle tendon

The present study was conducted to measure the individual threshold value for the somatosensory system of the human body, the thresholds value of vibratory stimulus were assessed through the ascent and descent methods. In the interests of the attainment of this study`s goal, comparing the thresholds value measured and change of state of the muscles when applied on the ankle tendon connected to muscles, changes in threshold measurement accuracy due to the differences in measuring methods were discussed. The experiment was conducted by constructing systems to stimulate somethetic sensibility by vibratory stimulus, ultrasound imaging system and EMG system. Five adult males were involved in this experiment. According to the results of experiments, the threshold value of somatosensory stimulation measured by the ascent method was greater than the threshold values measured by the descent method. And the muscular response to the somatosensory stimulation applied to the tibialis anterior tendon showed a larger rate of change with the ascending stimulus than with the descending stimulus. The results of this study could serve as a basis to discuss the reliability of the measurement method of the human body’s individual threshold value for the somatosensory system through the ascent and descent methods and can be used as reference data for the integration and performance threshold measurement methods

A study on the changes in gait characteristics by applying sub-threshold vibration stimulus in the ankle

This study was conducted to suggest the potential use of a mechanical vibration stimulus in the ankle to correct gait abnormalities. As for the mechanical vibration stimulus, different locations and durations are suggested based on the detection results of real-time gait patterns. 5 young males participated in this study. They were asked to perform assigned gait tasks when either a threshold or sub-threshold stimulus was applied in the tibialis anterior and Achilles tendon. The analysis results of gait cycle and muscle activity showed the changes on gait cycle, the activity pattern of used muscle for gait and the movement pattern of the ankle were observed based on the applied locations of vibration stimulus. Also, the result of sub-threshold stimulus showed similar effects as that of threshold stimulus. As such, the mechanical vibration stimulus was considered to affect gait by being adjusted its characteristics and local stimulus also would affect human body systemically. The result of this study can be used as basic data for the correction of individual’s specific gait abnormality and rehabilitation using vibration stimulus

Nasal carriage of Staphylococcus aureus among food handlers and restaurant workers in Ekpoma Edo State, Nigeria

Food handlers have been recognized to play a major role in the transmission of food borne diseases; contributing significantly to the global incidence and burden of the diseases. This study therefore, assesses the nasal carriage of staphylococcus aureus among food handlers and restaurant workers in Ekpoma, Edo State, Nigeria. A total of 100 nasal swab samples were collected and analyzed for Staphylococcus aureus using standard methods. The results showed that the prevalence of nasal carriage of Staphylococcus aureus among food handlers and restaurant workers in Ekpoma was 60%. The males had the highest prevalence of 58%, while the females had a prevalence rate of 42%. Those within age 26-30 had the highest prevalence of 67%, followed by those within the age group of ≤25 (17%) and 31-35(17%). Antibiotic sensitivity results showed that Gentamycin, Levofloxacin, Septrin, Rocephin and Ciprofloxacin had 100% sensitivity pattern, while Pefloxacin and Ampiclox exhibited 75% and 25% sensitivity patterns respectively. Ampicillin however, showed no sensitivity (0%). It is our opinion that concerted efforts need to be made to educate food handlers and restaurant workers on the importance of personal hygiene and the use of protective gadgets like nose masks while handling food products; since they serve as potential sources of staphylococcal food poisoning.Keywords: Food Handlers, Food borne diseases, Staphylococcus aureus, Nasal Carriage, Restaurant

Dual functionality anti-reflection and biocidal coatings

A thin film combination of anti-reflection (AR) and biocidal properties would be of particular interest to reduce the transfer of infection and improve readability of public high use touch screens. In this paper we describe the development of a dual functionality film of silica (AR) and copper oxide (biocidal). Deposition was via flame assisted chemical vapour deposition (FACVD) which has the advantages of being a cost efficient atmospheric pressure technique enabling use of non-volatile precursors and that no closed reaction cell is required so making it ideal for integration into industrial production lines. The resulting films were characterized by a range of techniques including optical spectroscopy, electron microscope and X-ray fluorescence. Biocidal behavior was tested by determining the kill rate of Escherichia coli. A 3 layer stack on glass of silica/copper oxide/silica had better adhesion and lower reflection than a comparable 2 layer stack. This multilayer film led to a > 2% drop in reflection from that of uncoated glass, similar to that of silica only film. In addition, showed a > 6 log10 kill between 6 and 24 h for as deposited and annealed samples