Cold uniform matter and neutron stars in the quark-mesons-coupling model

A new density dependent effective baryon-baryon interaction has been recently derived from the quark-meson-coupling (QMC) model, offering impressive results in application to finite nuclei and dense baryon matter. This self-consistent, relativistic quark-level approach is used to construct the Equation of State (EoS) and to calculate key properties of high density matter and cold, slowly rotating neutron stars. The results include predictions for the maximum mass of neutron star models, together with the corresponding radius and central density, as well the properties of neutron stars with mass of order 1.4 $M_\odot$. The cooling mechanism allowed by the QMC EoS is explored and the parameters relevant to slow rotation, namely the moment of inertia and the period of rotation investigated. The results of the calculation, which are found to be in good agreement with available observational data, are compared with the predictions of more traditional EoS. The QMC EoS provides cold neutron star models with maximum mass 1.9--2.1 M$_\odot$, with central density less than 6 times nuclear saturation density ($n_{0}= 0.16 {\rm fm}^{-3}$) and offers a consistent description of the stellar mass up to this density limit. In contrast with other models, QMC predicts no hyperon contribution at densities lower than $3n_0$, for matter in $\beta$-equilibrium. At higher densities, $\Xi^{-,0}$ and $\Lambda$ hyperons are present

Compositional tuning of ferromagnetism in Ga1-xMnxP

We report the magnetic and transport properties of Ga1-xMnxP synthesized via ion implantation followed by pulsed laser melting over a range of x, namely 0.018 to 0.042. Like Ga1-xMnxAs, Ga1-xMnxP displays a monotonic increase of the ferromagnetic Curie temperature with x associated with the hole-mediated ferromagnetic phase while thermal annealing above 300 C leads to a quenching of ferromagnetism that is accompanied by a reduction of the substitutional fraction of Mn. However, contrary to observations in Ga1-xMnxAs, Ga1-xMnxP is non-metallic over the entire composition range. At the lower temperatures over which the films are ferromagnetic, hole transport occurs via hopping conduction in a Mn-derived band; at higher temperatures it arises from holes in the valence band which are thermally excited across an energy gap that shrinks with x.Comment: To be published in Solid State Communication

The High Energy Telescope for STEREO

The IMPACT investigation for the STEREO Mission includes a complement of Solar Energetic Particle instruments on each of the two STEREO spacecraft. Of these instruments, the High Energy Telescopes (HETs) provide the highest energy measurements. This paper describes the HETs in detail, including the scientific objectives, the sensors, the overall mechanical and electrical design, and the on-board software. The HETs are designed to measure the abundances and energy spectra of electrons, protons, He, and heavier nuclei up to Fe in interplanetary space. For protons and He that stop in the HET, the kinetic energy range corresponds to ∼13 to 40 MeV/n. Protons that do not stop in the telescope (referred to as penetrating protons) are measured up to ∼100 MeV/n, as are penetrating He. For stopping He, the individual isotopes 3He and 4He can be distinguished. Stopping electrons are measured in the energy range ∼0.7–6 MeV

Free flux flow resistivity in strongly overdoped high-T_c cuprate; purely viscous motion of the vortices in semiclassical d-wave superconductor

We report the free flux flow (FFF) resistivity associated with a purely viscous motion of the vortices in moderately clean d-wave superconductor Bi:2201 in the strongly overdoped regime (T_c=16K) for a wide range of the magnetic field in the vortex state. The FFF resistivity is obtained by measuring the microwave surface impedance at different microwave frequencies. It is found that the FFF resistivity is remarkably different from that of conventional s-wave superconductors. At low fields (H<0.2H_c2) the FFF resistivity increases linearly with H with a coefficient which is far larger than that found in conventional s-wave superconductors. At higher fields, the FFF resistivity increases in proportion to \sqrt H up to H_c2. Based on these results, the energy dissipation mechanism associated with the viscous vortex motion in "semiclassical" d-wave superconductors with gap nodes is discussed. Two possible scenarios are put forth for these field dependence; the enhancement of the quasiparticle relaxation rate and the reduction of the number of the quasiparticles participating the energy dissipation in d-wave vortex state.Comment: 9 pages 7 figures, to appear in Phys. Rev.

A first-in-class, humanized antibody targeting alternatively spliced tissue factor: preclinical evaluation in an orthotopic model of pancreatic ductal adenocarcinoma

In 2021, pancreatic ductal adenocarcinoma (PDAC) is the 3(rd) leading cause of cancer deaths in the United States. This is largely due to a lack of symptoms and limited treatment options, which extend survival by only a few weeks. There is thus an urgent need to develop new therapies effective against PDAC. Previously, we have shown that the growth of PDAC cells is suppressed when they are co-implanted with RabMab1, a rabbit monoclonal antibody specific for human alternatively spliced tissue factor (asTF). Here, we report on humanization of RabMab1, evaluation of its binding characteristics, and assessment of its in vivo properties. hRabMab1 binds asTF with a K-D in the picomolar range; suppresses the migration of high-grade Pt45.P1 cells in Boyden chamber assays; has a long half-life in circulation (similar to 5 weeks); and significantly slows the growth of pre-formed orthotopic Pt45.P1 tumors in athymic nude mice when administered intravenously. Immunohistochemical analysis of tumor tissue demonstrates the suppression of i) PDAC cell proliferation, ii) macrophage infiltration, and iii) neovascularization, whereas RNAseq analysis of tumor tissue reveals the suppression of pathways that promote cell division and focal adhesion. This is the first proof-of-concept study whereby a novel biologic targeting asTF has been investigated as a systemically administered single agent, with encouraging results. Given that hRabMab1 has a favorable PK profile and is able to suppress the growth of human PDAC cells in vivo, it comprises a promising candidate for further clinical development.Thrombosis and Hemostasi

Rare decays Bˉ→Xs(d)γ\bar{B}\to X_{s(d)}\gamma at the NLO

We present an independent calculation of ${\cal{O}}(\alpha_s)$ matrix elements of the QCD penguin operators for the decays $\bar{B}\to X_{s(d)}\gamma$. The Mellin-Barnes representation technique is applied for the systematic numerical evaluation of involved two-loop diagrams. The numerical effect of the calculated contributions is confirmed to be of order of 1%. We also present an updated numerical analysis for $\bar{B}\to X_{s(d)}\gamma$ decay rates.Comment: 15 pages, 4 figure

Early- Onset Stroke and Vasculopathy Associated with Mutations in ADA2

Adenosine deaminase 2 (ADA2) is an enzyme involved in purine metabolism and a growth factor that influences the development of endothelial cells and leukocytes. This study shows that defects in ADA2 cause recurrent fevers, vascular pathologic features, and mild immunodeficiency. Patients with autoinflammatory disease sometimes present with clinical findings that encompass multiple organ systems.(1) Three unrelated children presented to the National Institutes of Health (NIH) Clinical Center with intermittent fevers, recurrent lacunar strokes, elevated levels of acute-phase reactants, livedoid rash, hepatosplenomegaly, and hypogammaglobulinemia. Collectively, these findings do not easily fit with any of the known inherited autoinflammatory diseases. Hereditary or acquired vascular disorders can have protean manifestations yet be caused by mutations in a single gene. Diseases such as the Aicardi-Goutieres syndrome,(2),(3) polypoidal choroidal vasculopathy,(4) sickle cell anemia,(5) livedoid vasculopathy,(6) and the small-vessel vasculitides(7),(8) are examples of systemic ...</p