26 research outputs found
Second and Third Order Observables of the Two-Matrix Model
In this paper we complement our recent result on the explicit formula for the
planar limit of the free energy of the two-matrix model by computing the second
and third order observables of the model in terms of canonical structures of
the underlying genus g spectral curve. In particular we provide explicit
formulas for any three-loop correlator of the model. Some explicit examples are
worked out.Comment: 22 pages, v2 with added references and minor correction
Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk
Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored.
Methods: We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium.
Results: Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 [conditional P = 2.51 × 10−4; OR, 1.04; 95% confidence interval (CI), 1.02–1.07] and rs77928427 (P = 1.86 × 10−4; OR, 1.04; 95% CI, 1.02–1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional variants, rs62331150 and rs73838678 in linkage disequilibrium (LD) with rs9790517 (r2 ≥ 0.90) residing in the active promoter or enhancer, respectively, of the nearest gene, TET2. Both variants are located in DNase I hypersensitivity and transcription factor–binding sites. Using data from both The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), we showed that rs62331150 was associated with level of expression of TET2 in breast normal and tumor tissue.
Conclusion: Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of TET2.
Impact: Fine-mapping study with large sample size warranted for identification of independent loci for breast cancer risk
Designing two-echelon supply networks
10.1016/j.ejor.2006.02.016European Journal of Operational Research1782449-462EJOR
Attitudes and perception of influenza vaccines among older people in Singapore: A qualitative study
Effect of polarization on laser-induced surface-temperature rise
10.1007/BF00323620Applied Physics A Solids and Surfaces584423-429APAM