Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia.

BACKGROUND: In first-episode schizophrenia, longer duration of untreated psychosis (DUP) predicts poorer outcomes. AIMS: To address whether the relationship between DUP and outcome is a direct causal one or the result of association between symptoms and/or cognitive functioning and social functioning at the same time point. METHOD: Symptoms, social function and cognitive function were assessed in 98 patients with first-episode schizphrenia at presentation and 1 year later. RESULTS: There was no significant clinical difference between participants with short and long DUP at presentation. Linear regression analyses revealed that longer DUP significantly predicted more severe positive and negative symptoms and poorer social function at 1 year, independent of scores at presentation. Path analyses revealed independent direct relationships between DUP and social function, core negative symptoms and positive symptoms. There was no significant association between DUP and cognition. CONCLUSIONS: Longer DUP predicts poor social function independently of symptoms. The findings underline the importance of taking account of the phenomenological overlap between measures of negative symptoms and social function when investigating the effects of DUP

Cloning transformations in spin networks without external control

In this paper we present an approach to quantum cloning with unmodulated spin networks. The cloner is realized by a proper design of the network and a choice of the coupling between the qubits. We show that in the case of phase covariant cloner the XY coupling gives the best results. In the 1->2 cloning we find that the value for the fidelity of the optimal cloner is achieved, and values comparable to the optimal ones in the general N->M case can be attained. If a suitable set of network symmetries are satisfied, the output fidelity of the clones does not depend on the specific choice of the graph. We show that spin network cloning is robust against the presence of static imperfections. Moreover, in the presence of noise, it outperforms the conventional approach. In this case the fidelity exceeds the corresponding value obtained by quantum gates even for a very small amount of noise. Furthermore we show how to use this method to clone qutrits and qudits. By means of the Heisenberg coupling it is also possible to implement the universal cloner although in this case the fidelity is 10% off that of the optimal cloner.Comment: 12 pages, 13 figures, published versio

Spin Star as Switch for Quantum Networks

Quantum state transfer is an important task in quantum information processing. It is known that one can engineer the couplings of a one-dimensional spin chain to achieve the goal of perfect state transfer. To leverage the value of these spin chains, a spin star is potentially useful for connecting different parts of a quantum network. In this work, we extend the spin-chain engineering problem to the problems with a topology of a star network. We show that a permanently coupled spin star can function as a network switch for transferring quantum states selectively from one node to another by varying the local potentials only. Together with one-dimensional chains, this result allows applications of quantum state transfer be applied to more general quantum networks.Comment: 10 pages, 2 figur

In search of phylogenetic congruence between molecular and morphological data in bryozoans with extreme adult skeletal heteromorphy

peerreview_statement: The publishing and review policy for this title is described in its Aims & Scope. aims_and_scope_url: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=tsab20© Crown Copyright 2015. This document is the author's final accepted/submitted version of the journal article. You are advised to consult the publisher's version if you wish to cite from it

Determination of earthquake energy release and M_L using TERRAscope

We estimated the energy radiated by earthquakes in southern California using on-scale very broadband recordings from TERRAscope. The method we used involves time integration of the squared ground-motion velocity and empirical determination of the distance attenuation function and the station corrections. The time integral is typically taken over a duration of 2 min after the P-wave arrival. The attenuation curve for the energy integral we obtained is given by q(r) = cr^(−n)exp(−kr)(r^2 = Δ^2 + h_(ref)^2) with c = 0.49710, n = 1.0322, k = 0.0035 km^(−1), and h_(ref) = 8 km, where Δ is the epicentral distance. A similar method was used to determine M_L using TERRAscope data. The station corrections for M_L are determined such that the M_L values determined from TERRAscope agree with those from the traditional optical Wood-Anderson seismographs. For 1.5 6.5, M_L saturates. The ratio E_S/M_0 (M_0: seismic moment), a measure of the average stress drop, for six earthquakes, the 1989 Montebello earthquake (M_L = 4.6), the 1989 Pasadena earthquake (M_L = 4.9), the 1990 Upland earthquake (M_L = 5.2), the 1991 Sierra Madre earthquake (M_L = 5.8), the 1992 Joshua Tree earthquake (M_L = 6.1), and the 1992 Landers earthquake (M_w = 7.3), are about 10 times larger than those of the others that include the aftershocks of the 1987 Whittier Narrows earthquake, the Sierra Madre earthquake, the Joshua Tree earthquake, and the two earthquakes on the San Jacinto fault. The difference in the stress drop between the mainshock and their large aftershocks may be similar to that between earthquakes on a fault with long and short repeat times. The aftershocks, which occurred on the fault plane where the mainshock slippage occurred, had a very short time to heal, hence a low stress drop. The repeat time of the major earthquakes on the frontal fault systems in the Transverse Ranges in southern California is believed to be very long, a few thousand years. Hence, the events in the Transverse Ranges may have higher stress drops than those of the events occurring on faults with shorter repeat times, such as the San Andreas fault and the San Jacinto fault. The observation that very high stress-drop events occur in the Transverse Ranges and the Los Angeles Basin has important implications for the regional seismic potential. The occurrence of these high stress-drop events near the bottom of the seismogenic zone strongly suggests that these fault systems are capable of supporting high stress that will eventually be released in major seismic events. Characterization of earthquakes in terms of the E_S/M_0 ratio using broadband data will help delineate the spatial distribution of seismogenic stresses in the Los Angeles basin and the Transverse Ranges

Ethical issues in implementation research: a discussion of the problems in achieving informed consent

Background: Improved quality of care is a policy objective of health care systems around the world. Implementation research is the scientific study of methods to promote the systematic uptake of clinical research findings into routine clinical practice, and hence to reduce inappropriate care. It includes the study of influences on healthcare professionals' behaviour and methods to enable them to use research findings more effectively. Cluster randomized trials represent the optimal design for evaluating the effectiveness of implementation strategies. Various codes of medical ethics, such as the Nuremberg Code and the Declaration of Helsinki inform medical research, but their relevance to cluster randomised trials in implementation research is unclear. This paper discusses the applicability of various ethical codes to obtaining consent in cluster trials in implementation research. Discussion: The appropriate application of biomedical codes to implementation research is not obvious. Discussion of the nature and practice of informed consent in implementation research cluster trials must consider the levels at which consent can be sought, and for what purpose it can be sought. The level at which an intervention is delivered can render the idea of patient level consent meaningless. Careful consideration of the ownership of information, and rights of access to and exploitation of data is required. For health care professionals and organizations, there is a balance between clinical freedom and responsibility to participate in research. Summary: While ethical justification for clinical trials relies heavily on individual consent, for implementation research aspects of distributive justice, economics, and political philosophy underlie the debate. Societies may need to trade off decisions on the choice between individualized consent and valid implementation research. We suggest that social sciences codes could usefully inform the consideration of implementation research by members of Research Ethics Committees

The languages of peace during the French religious wars

The desirability of peace was a common topos in sixteenth-century political rhetoric, and the duty of the king to uphold the peace for the benefit of his subjects was also a long-established tradition. However, the peculiar circumstances of the French religious wars, and the preferred royal policy of pacification, galvanized impassioned debate among both those who supported and those who opposed confessional coexistence. This article looks at the diverse ways in which peace was viewed during the religious wars through an exploration of language and context. It draws not only on the pronouncements of the crown and its officials, and of poets and jurists, but also on those of local communities and confessional groups. Opinion was not just divided along religious lines; political imperatives, philosophical positions and local conditions all came into play in the arguments deployed. The variegated languages of peace provide a social and cultural dimension for the contested nature of sixteenth-century French politics. However, they could not restore harmony to a war-torn and divided kingdom

Thorium Energy Futures

The potential for thorium as an alternative or supplement to uranium in fission power generation has long been recognised, and several reactors, of various types, have already operated using thorium-based fuels. Accelerator Driven Subcritical (ADS) systems have benefits and drawbacks when compared to conventional critical thorium reactors, for both solid and molten salt fuels. None of the four options – liquid or solid, with or without an accelerator – can yet be rated as better or worse than the other three, given today's knowledge. We outline the research that will be necessary to lead to an informed choice

The Landlab v1.0 OverlandFlow component: a Python tool for computing shallow-water flow across watersheds

Representation of flowing water in landscape evolution models (LEMs) is often simplified compared to hydrodynamic models, as LEMs make assumptions reducing physical complexity in favor of computational efficiency. The Landlab modeling framework can be used to bridge the divide between complex runoff models and more traditional LEMs, creating a new type of framework not commonly used in the geomorphology or hydrology communities. Landlab is a Python-language library that includes tools and process components that can be used to create models of Earth-surface dynamics over a range of temporal and spatial scales. The Landlab OverlandFlow component is based on a simplified inertial approximation of the shallow water equations, following the solution of de Almeida et al. (2012). This explicit two-dimensional hydrodynamic algorithm simulates a flood wave across a model domain, where water discharge and flow depth are calculated at all locations within a structured (raster) grid. Here we illustrate how the OverlandFlow component contained within Landlab can be applied as a simplified event-based runoff model and how to couple the runoff model with an incision model operating on decadal timescales. Examples of flow routing on both real and synthetic landscapes are shown. Hydrographs from a single storm at multiple locations in the Spring Creek watershed, Colorado, USA, are illustrated, along with a map of shear stress applied on the land surface by flowing water. The OverlandFlow component can also be coupled with the Landlab DetachmentLtdErosion component to illustrate how the nonsteady flow routing regime impacts incision across a watershed. The hydrograph and incision results are compared to simulations driven by steady-state runoff. Results from the coupled runoff and incision model indicate that runoff dynamics can impact landscape relief and channel concavity, suggesting that on landscape evolution timescales, the OverlandFlow model may lead to differences in simulated topography in comparison with traditional methods. The exploratory test cases described within demonstrate how the OverlandFlow component can be used in both hydrologic and geomorphic applications