Investigations of electron helicity in optically active molecules using polarized beams of electrons and positrons

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43345/1/11084_2004_Article_BF00927996.pd

Cortical thickness and resting-state cardiac function across the lifespan: a cross-sectional pooled mega analysis

Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega-analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12-87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS – or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between cortical thickness and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research

Über Kumulene VIII*); Reduktion von Acetylen‐, Diacetylen‐ und Triacetylen‐glykolen mit Zinn‐(II)‐chlorid; Kumulene mit nur zwei aromatischen Substituenten

Durch Zinn (II)‐chlorid lassen sich aus Acetylen‐, Diacetylen‐ und Triacetylen‐glykolen die Oxygruppen entfernen. Es wurden Ausbeuten bis zu 94.5% d. Th. an reinem Kumulen erhalten. Diese Methode hat es ermöglicht, 2 Hexapentaene in Lösung zu gewinnen, die nur 2 aromatische Substituenten tragen (1.6‐Diphenyl‐hexapentaen und 1.6‐Dimethyl‐1.6‐diphenyl‐hexapentaen, die im Gemisch mit Polyinen erhalten wurden) und ein nur disubstituiertes Butatrien (1.4‐Distyryl‐butatrien, Schmp. 309—311°), frei von Diin, kristallisiert zu erhalten