231 research outputs found
Integer spin-chain antiferromagnetism of the 4d oxide CaRuO3 with post-perovskite structure
A quasi-one dimensional magnetism was discovered in the post-perovskite
CaRuO3 (Ru4+: 4d4, Cmcm), which is iso-compositional with the perovskite CaRuO3
(Pbnm). An antiferromagnetic spin-chain function with -J/kB = 350 K well
reproduces the experimental curve of the magnetic susceptibility vs.
temperature, suggesting long-range antiferromagnetic correlations. The
anisotropic magnetism is probably owing to the dyz - 2p- dzx and dzx - 2p- dyz
superexchange bonds along a-axis. The Sommerfeld coefficient of the specific
heat is fairly small, 0.16(2) mJ mol-1 K-2, indicating that the magnetism
reflects localized nature of the 4d electrons. As far as we know, this is the
first observation of an integer (S = 1) spin-chain antiferromagnetism in the 4d
electron system.Comment: Accepted for publication in Phys. Rev.
Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment
Introduction: The mammary primordium forms during embryogenesis as a result of inductive interactions between its constitutive tissues, the mesenchyme and epithelium, and represents the earliest evidence of commitment to the mammary lineage. Previous studies of embryonic mouse mammary epithelium indicated that, by mid-gestation, these cells are determined to a mammary cell fate and that a stem cell population has been delimited. Mammary mesenchyme can induce mammary development from simple epithelium even across species and classes, and can partially restore features of differentiated tissue to mouse mammary tumours in co-culture experiments. Despite these exciting properties, the molecular identity of embryonic mammary cells remains to be fully characterised.
Methods: Here, we define the transcriptome of the mammary primordium and the two distinct cellular compartments that comprise it, the mammary primordial bud epithelium and mammary mesenchyme. Pathway and network analysis was performed and comparisons of embryonic mammary gene expression profiles to those of both postnatal mouse and human mammary epithelial cell sub-populations and stroma were made.
Results: Several of the genes we have detected in our embryonic mammary cell signatures were previously shown to regulate mammary cell fate and development, but we also identified a large number of novel candidates. Additionally, we determined genes that were expressed by both embryonic and postnatal mammary cells, which represent candidate regulators of mammary cell fate, differentiation and progenitor cell function that could signal from mammary lineage inception during embryogenesis through postnatal development. Comparison of embryonic mammary cell signatures with those of human breast cells identified potential regulators of mammary progenitor cell functions conserved across species.
Conclusions: These results provide new insights into genetic regulatory mechanisms of mammary development, particularly identification of novel potential regulators of mammary fate and mesenchymal-epithelial cross-talk. Since cancers may represent diseases of mesenchymal-epithelial communications, we anticipate these results will provide foundations for further studies into the fundamental links between developmental, stem cell and breast cancer biology
Yersinia pseudotuberculosis infection in Kawasaki disease and its clinical characteristics
The Magnetoelectric Effect in Transition Metal Oxides: Insights and the Rational Design of New Materials from First Principles
The search for materials displaying a large magnetoelectric effect has
occupied researchers for many decades. The rewards could include not only
advanced electronics technologies, but also fundamental insights concerning the
dielectric and magnetic properties of condensed matter. In this article, we
focus on the magnetoelectric effect in transition metal oxides and review the
manner in which first-principles calculations have helped guide the search for
(and increasingly, predicted) new materials and shed light on the microscopic
mechanisms responsible for magnetoelectric phenomena.Comment: 24 pages, 12 figure
Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration
Li1.5La1.5MO6 (M = W6+, Te6+) as a new series of lithium-rich double perovskites for all-solid-state lithium-ion batteries
Solid-state batteries are a proposed route to safely achieving high energy densities, yet this architecture faces challenges arising from interfacial issues between the electrode and solid electrolyte. Here we develop a novel family of double perovskites, Li1.5La1.5MO6 (M = W6+, Te6+), where an uncommon lithium-ion distribution enables macroscopic ion diffusion and tailored design of the composition allows us to switch functionality to either a negative electrode or a solid electrolyte. Introduction of tungsten allows reversible lithium-ion intercalation below 1 V, enabling application as an anode (initial specific capacity >200 mAh g-1 with remarkably low volume change of ∼0.2%). By contrast, substitution of tungsten with tellurium induces redox stability, directing the functionality of the perovskite towards a solid-state electrolyte with electrochemical stability up to 5 V and a low activation energy barrier (<0.2 eV) for microscopic lithium-ion diffusion. Characterisation across multiple length- and time-scales allows interrogation of the structure-property relationships in these materials and preliminary examination of a solid-state cell employing both compositions suggests lattice-matching avenues show promise for all-solid-state batteries
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