Актуальность социогуманитарного подхода к исследованию конвергентных технологий в условиях современного информационно-коммуникативного пространства

The paper presents theoretical and methodological dimensions of convergent technologies and risks connected with them. These risks stipulate for the adequate socio-humanistic analysis of the practical applications of these technologies

Massless particles on supergroups and AdS3 x S3 supergravity

Firstly, we study the state space of a massless particle on a supergroup with a reparameterization invariant action. After gauge fixing the reparameterization invariance, we compute the physical state space through the BRST cohomology and show that the quadratic Casimir Hamiltonian becomes diagonalizable in cohomology. We illustrate the general mechanism in detail in the example of a supergroup target GL(1|1). The space of physical states remains an indecomposable infinite dimensional representation of the space-time supersymmetry algebra. Secondly, we show how the full string BRST cohomology in the particle limit of string theory on AdS3 x S3 renders the quadratic Casimir diagonalizable, and reduces the Hilbert space to finite dimensional representations of the space-time supersymmetry algebra (after analytic continuation). Our analysis provides an efficient way to calculate the Kaluza-Klein spectrum for supergravity on AdS3 x S3. It may also be a step towards the identification of an interesting and simpler subsector of logarithmic supergroup conformal field theories, relevant to string theory.Comment: 16 pages, 10 figure

Regional-Scale Simulations of Fungal Spore Aerosols Using an Emission Parameterization Adapted to Local Measurements of Fluorescent Biological Aerosol Particles

Fungal spores as a prominent type of primary biological aerosol particles (PBAP) have been incorporated into the COSMO-ART (Consortium for Small-scale Modelling- Aerosols and Reactive Trace gases) regional atmospheric model. Two literature-based emission rates for fungal spores derived from fungal spore colony counts and chemical tracer measurements were used as a parameterization baseline for this study. A third, new emission parameterization for fluorescent biological aerosol particles (FBAP) was adapted to field measurements from four locations across Europe. FBAP concentrations can be regarded as a lower estimate of total PBAP concentrations. Size distributions of FBAP often show a distinct mode at approx. 3 μm, corresponding to a diameter range characteristic for many fungal spores. Previous studies for several locations have suggested that FBAP are in many cases dominated by fungal spores. Thus, we suggest that simulated FBAP and fungal spore concentrations obtained from the three different emission parameterizations can be compared to FBAP measurements. The comparison reveals that simulated fungal spore concentrations based on literature emission parameterizations are lower than measured FBAP concentrations. In agreement with the measurements, the model results show a diurnal cycle in simulated fungal spore concentrations, which may develop partially as a consequence of a varying boundary layer height between day and night. Temperature and specific humidity, together with leaf area index (LAI), were chosen to drive the new emission parameterization which is fitted to the FBAP observations. The new parameterization results in similar root mean square errors (RMSEs) and correlation coefficients compared to the FBAP observations as the previously existing fungal spore emission parameterizations, with some improvements in the bias. Using the new emission parameterization on a model domain covering western Europe, FBAP in the lowest model layer comprise a fraction of 15% of the total aerosol mass over land and reach average number concentrations of 26 L�1. The results confirm that fungal spores and biological particles may account for a major fraction of supermicron aerosol particle number and mass concentration over vegetated continental regions and should thus be explicitly considered in air quality and climate studies

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume.

Cranial growth and development is a complex process which affects the closely related traits of head circumference (HC) and intracranial volume (ICV). The underlying genetic influences shaping these traits during the transition from childhood to adulthood are little understood, but might include both age-specific genetic factors and low-frequency genetic variation. Here, we model the developmental genetic architecture of HC, showing this is genetically stable and correlated with genetic determinants of ICV. Investigating up to 46,000 children and adults of European descent, we identify association with final HC and/or final ICV + HC at 9 novel common and low-frequency loci, illustrating that genetic variation from a wide allele frequency spectrum contributes to cranial growth. The largest effects are reported for low-frequency variants within TP53, with 0.5 cm wider heads in increaser-allele carriers versus non-carriers during mid-childhood, suggesting a previously unrecognized role of TP53 transcripts in human cranial development