Views on computer program documentation and automation

Various aspects of the problem of program documentation and description are discussed. Particular emphasis is placed on the problem of semantics. It is pointed out that the information produced by documentation of a program, if presented to several different groups, may mean entirely different things to these groups. Recognition of the fact that people look at problems differently is proposed as a more practical approach to the problem of documentation rather than extensive use of standards or strict formatting. The difficulties involved in searching for ways to provide a common ground for the transmission and use of information are discussed

On a criterion for vortex breakdown

A criterion for the onset of vortex breakdown is proposed. Based upon previous experimental, computational, and theoretical studies, an appropriately defined local Rossby number is used to delineate the region where breakdown occurs. In addition, new numerical results are presented which further validate this criterion. A number of previous theoretical studies concentrating on inviscid standing-wave analyses for trailing wing-tip vortices are reviewed and reinterpreted in terms of the Rossby number criterion. Consistent with previous studies, the physical basis for the onset of breakdown is identified as the ability of the flow to sustain such waves. Previous computational results are reviewed and re-evaluated in terms of the proposed breakdown criterion. As a result, the cause of breakdown occurring near the inflow computational boundary, common to several numerical studies, is identified. Finally, previous experimental studies of vortex breakdown for both leading edge and trailing wing-tip vortices are reviewed and quantified in terms of the Rossby number criterion

Feasibility study for a scanning celestial attitude determination system SCADS on the IMP spacecraft Final report

System design analysis to establish feasibility of using electro-optical celestial scanning sensor on IMP spacecraft for determination of spacecraft attitude by star measurement

Net Energy of Finishing Diets Containing Light or Normal Test Weight Corn

Net energy (NE) of diets containing 77.7% whole corn of either normal (53.8 Ib/bushel, NC) or light (40.8 Ib/bushel, LC) test weight was determined by total collection and indirect respiration calorimetry using six crossbred steers (avg wt 327 kg). Diet treatments were applied in a switchback design. The steers were initially adapted to ad libitum intake of either NC or LC diets for 32 days followed by 7 days total feces and urine collection. Gaseous exchange was subsequently measured for at least 48 hours. Intake was then reduced to an estimated 1.1 times maintenance for 6 days and collections were repeated. The steers were then switched between NC and LC diets and the entire process was repeated. As a percentage of gross energy consumed, fecal energy losses were 32% greater for the NC diet compared to LC (P\u3c .01). Urinary energy losses were unaffected by diet (P \u3e .20). Although energy lost as methane did not differ between diets at high intake, it was 27% greater for LC than NC at low intake (interaction P.20). Partial efficiencies of ME used for maintenance (k,) and gain (k,), as well as ME required for maintenance, also were not different (P\u3e.20). Diet NE for maintenance and gain was 13% greater for LC than NC. NE estimates calculated by difference for light and normal whole corn were 2.48, 1.65, 2.15 and 1.43 mcal/kg dry matter, respectively. These data demonstrate that corn of low test weight is not inherently lower in NE content than normal corn

Everolimus dosing recommendations for tuberous sclerosis complex–associated refractory seizures

ObjectiveThe present analysis examined the exposure-response relationship by means of the predose everolimus concentration (C-min) and the seizure response in patients with tuberous sclerosis complex-associated seizures in the EXIST-3 study. Recommendations have been made for the target C-min range of everolimus for therapeutic drug monitoring (TDM) and the doses necessary to achieve this target C-min

Increased risk of interstitial fibrosis and tubular atrophy in controlled donation after circulatory death kidney transplantation

Introduction: Comparable transplant outcomes between controlled donation after circulatory death (cDCD) and donation after brain death (DBD) kidney transplantation (KT) have been confirmed. However, few data describes the histology of cDCD-KT which is subjected to prolonged procurement warm ischemia. This study aimed to evaluate the rate of interstitial fibrosis (IF) and tubular atrophy (TA) on the surveillance biopsy performed in our unit between the 2 and 6 months post KT. Acute rejection was considered as secondary endpoint. Patients and Methods: 330 KT (226 DBD and 104 DCD) have been performed between 2008 and 2014. Surveillance or per-cause biopsy was performed in 272 recipients. Among them, the rate of adequate (≥8 glomeruli and ≥1 large-sized artery) was 76.8%. Results: IFTA was found in 11.5% and 25.7% of DBD and cDCD-KT, respectively (p = 0.004). Considering IF and TA separately, the corresponding rates were 20.4% vs 32% (p = 0.04) and 23% vs 36% (p = 0.03), respectively. If acute rejection before routine biopsy was excluded, either IF or TA rate was significantly higher in cDCD- than DBD-KT (12.6% vs 27.1%, p = 0.006; 17.6% vs 31.4%, p = 0.016; and 20.9% vs 35.7%, p = 0.015 in case of IF-TA, IF, and TA, respectively). A cDCD-KT compared to a DBD-KT was 3.11 (95%CI 1.51– 6.43, p = 0.002), 2.34 (95%CI 1.21–4.53, p = 0.011) and 2.29 (95%CI 1.23– 4.27, p = 0.009) times more likely to have IFTA, IF, and TA, respectively. Extended criteria donor (ECD) vs standard criteria donor (SCD) was also an independent risk factor for IFTA (OR = 3.11, 95%CI 1.51–6.43, p = 0.002), IF (OR = 4.86, 95%CI 1.96–12.05, p = 0.001), and TA (OR = 4.09, 95%CI 1.68– 9.93, p = 0.002). The rate of acute rejection diagnosed by SB was 7.1% and 8.9% in DBD and cDCD kidney grafts (p = ns), respectively.Conclusion: KT from cDCD increased the risk of IF-TA between 3 and 6 months post-transplant. Further studies are warranted to investigate the evolution of this phenomenon over time and its effect on graft function

The Savvidy ``ferromagnetic vacuum'' in three-dimensional lattice gauge theory

The vacuum effective potential of three-dimensional SU(2) lattice gauge theory in an applied color-magnetic field is computed over a wide range of field strengths. The background field is induced by an external current, as in continuum field theory. Scaling and finite volume effects are analyzed systematically. The first evidence from lattice simulations is obtained of the existence of a nontrivial minimum in the effective potential. This supports a ``ferromagnetic'' picture of gluon condensation, proposed by Savvidy on the basis of a one-loop calculation in (3+1)-dimensional QCD.Comment: 9pp (REVTEX manuscript). Postscript figures appende

Path integral solution for an angle-dependent anharmonic oscillator

We have given a straightforward method to solve the problem of noncentral anharmonic oscillator in three dimensions. The relative propagator is presented by means of path integrals in spherical coordinates. By making an adequate change of time we were able to separate the angular motion from the radial one. The relative propagator is then exactly calculated. The energy spectrum and the corresponding wave functions are obtained.Comment: Corrected typos and mistakes, To appear in Communications in Theoretical Physic