Memahami Kebudayaan Lokal Papua : suatu Pendekatan Pembangunan yang Manusiawi di Tanah Papua

Tulisan bertujuan untuk memberi pemahaman kepada pemerintah agar dalam membangun orang Papua haruslah menggunakan pendekatan budaya dari pada menggunakan pendekatan keamanan yang tidak akan menyelesaikan masalah sosialnya. Orang Papua terdiri dari 254 suku bangsa yang mendiami 4 zona ekologis, yaitu : (1) zona rawa, pantai dan sepanjang aliran sungai; (2) zona dataran tinggi; (3) zona kaki gunung dan lembah-lembah kecil; dan (4) zona dataran rendah, pesisir dan kepulauan. Orang Papua tersebar mendiami 4 zona tersbut, sehingga untuk membangun mereka tidak bisa menyamaratakan mereka karena karekteristikan budaya mereka berbeda sesuai dengan zona yang mereka diami. Dikemukakan pula beberapa kasus pembangunan yang gagal akibat dari pembangunan yang sifatnya top down sehingga bertentangan dengan karakteristik budaya mereka yang telah dibangun sejak nenek moyang mereka. Melalui tulisan ini, pendekatan budaya disarankan harus digunakan sebagai media pembangunan paling penting untuk suatu Perubahan

MEMAHAMI KEBUDAYAAN LOKAL PAPUA : SUATU PENDEKATAN PEMBANGUNAN YANG MANUSIAWI DI TANAH PAPUA

Abstrak: Tulisan bertujuan untuk memberi pemahaman kepada pemerintah agar dalam membangun orang Papua haruslah menggunakan pendekatan budaya dari pada menggunakan pendekatan keamanan yang tidak akan menyelesaikan masalah sosialnya. Orang Papua terdiri dari 254 suku bangsa yang mendiami 4 zona ekologis, yaitu : (1) zona rawa, pantai dan sepanjang aliran sungai; (2) zona dataran tinggi; (3) zona kaki gunung dan lembah-lembah kecil; dan (4) zona dataran rendah, pesisir dan kepulauan. Orang Papua tersebar mendiami 4 zona tersbut, sehingga untuk membangun mereka tidak bisa menyamaratakan mereka karena karekteristikan budaya mereka berbeda sesuai dengan zona yang mereka diami. Dikemukakan pula beberapa kasus pembangunan yang gagal akibat dari pembangunan yang sifatnya top down sehingga bertentangan dengan karakteristik budaya mereka yang telah dibangun sejak nenek moyang mereka. Melalui tulisan ini, pendekatan budaya disarankan harus digunakan sebagai media pembangunan paling penting untuk suatu perubahan.Kata Kunci : Pendekatan Budaya, Orang Papu

Incidence and Outcome of Progressive Multifocal Leukoencephalopathy over 20 Years of the Swiss HIV Cohort Study

Background. We investigated the incidence and outcome of progressive multifocal leukoencephalopathy (PML) in human immunodeficiency virus (HIV)-infected individuals before and after the introduction of combination antiretroviral therapy (cART) in 1996. Methods. From 1988 through 2007, 226 cases of PML were reported to the Swiss HIV Cohort Study. By chart review, we confirmed 186 cases and recorded all-cause and PML-attributable mortality. For the survival analysis, 25 patients with postmortem diagnosis and 2 without CD4+ T cell counts were excluded, leaving a total of 159 patients (89 before 1996 and 70 during 1996-2007). Results. The incidence rate of PML decreased from 0.24 cases per 100 patient-years (PY; 95% confidence interval [CI], 0.20-0.29 cases per 100 PY) before 1996 to 0.06 cases per 100 PY (95% CI, 0.04-0.10 cases per 100 PY) from 1996 onward. Patients who received a diagnosis before 1996 had a higher frequency of prior acquired immunodeficiency syndrome-defining conditions (P=.007) but similar CD4+ T cell counts (60 vs. 71 cells/µL; P=.25), compared with patients who received a diagnosis during 1996 or thereafter. The median time to PML-attributable death was 71 days (interquartile range, 44-140 days), compared with 90 days (interquartile range, 54-313 days) for all-cause mortality. The PML-attributable 1-year mortality rate decreased from 82.3 cases per 100 PY (95% CI, 58.8-115.1 cases per 100 PY) during the pre-cART era to 37.6 cases per 100 PY (95% CI, 23.4.-60.5 cases per 100 PY) during the cART era. In multivariate models, cART was the only factor associated with lower PML-attributable mortality (hazard ratio, 0.18; 95% CI, 0.07-0.50; P<.001), whereas all-cause mortality was associated with baseline CD4+ T cell count (hazard ratio per increase of 100 cells/µL, 0.52; 95% CI, 0.32-0.85; P=.010) and cART use (hazard ratio, 0.37; 95% CI, 0.19-0.75; P=.006). Conclusions. cART reduced the incidence and PML-attributable 1-year mortality, regardless of baseline CD4+ T cell count, whereas overall mortality was dependant on cART use and baseline CD4+ T cell coun

Phytochemical Screening and Antioxidant Activity of Selekop (Lepisanthes Amoena) Fruit

Selekop (Lepisanthes amoena (Hassk.) Leenh.) plant leaves are used by the Dayak tribe of East Kalimantan as traditional cosmetics. Selekop fruit is also edible, but not well known. This study was conducted to obtain the phytochemical content and antioxidant assay in flesh, seed and pericarp extracts from the fruit of Selekop. Phytochemical analysis was conducted on ethanol extract for identification of flavonoid, alkaloid, tannin, saponin, triterpenoid and steroid. The antioxidant activity was done by DPPH assay with ascorbic acid as positive control. The flesh contained flavonoid, saponin, and tannin; the seed contained flavonoid, alkaloid, saponin, triterpenoid, and tannin; and the pericarp contained flavonoid, alkaloid, saponin, triterpenoid, and tannin. Analysis of antioxidant activity revealed the following Inhibitory Concentration (IC50 values): 122.51 ppm of flesh, 63.30 ppm of seed, 53.21 ppm of pericarp and 3.06 ppm of ascorbic acid. Based on these results, the ethanol extract of the seed and the flesh had a phytochemical content and antioxidant activity which was better than the flesh extract from Selekop fuit

The ultraluminous GRB 110918A

GRB 110918A is the brightest long GRB detected by Konus-WIND during its 19 years of continuous observations and the most luminous GRB ever observed since the beginning of the cosmological era in 1997. We report on the final IPN localization of this event and its detailed multiwavelength study with a number of space-based instruments. The prompt emission is characterized by a typical duration, a moderare $E_{peak}$ of the time-integrated spectrum, and strong hard-to-soft evolution. The high observed energy fluence yields, at z=0.984, a huge isotropic-equivalent energy release $E_{iso}=(2.1\pm0.1)\times10^{54}$ erg. The record-breaking energy flux observed at the peak of the short, bright, hard initial pulse results in an unprecedented isotropic-equivalent luminosity $L_{iso}=(4.7\pm0.2)\times10^{54}$erg s$^{-1}$. A tail of the soft gamma-ray emission was detected with temporal and spectral behavior typical of that predicted by the synchrotron forward-shock model. Swift/XRT and Swift/UVOT observed the bright afterglow from 1.2 to 48 days after the burst and revealed no evidence of a jet break. The post-break scenario for the afterglow is preferred from our analysis, with a hard underlying electron spectrum and ISM-like circumburst environment implied. We conclude that, among multiple reasons investigated, the tight collimation of the jet must have been a key ingredient to produce this unusually bright burst. The inferred jet opening angle of 1.7-3.4 deg results in reasonable values of the collimation-corrected radiated energy and the peak luminosity, which, however, are still at the top of their distributions for such tightly collimated events. We estimate a detection horizon for a similar ultraluminous GRB of $z\sim7.5$ for Konus-WIND, and $z\sim12$ for Swift/BAT, which stresses the importance of GRBs as probes of the early Universe.Comment: 22 pages, 20 figures, accepted for publication in Ap

Indian Affairs in Dakota. Memorial and Resolution of the Legislative Assembly of the Territory of Dakota Relative to Indian Affairs in Said Territory

This Memorial and Resolution of the legislature of the Territory of Dakota, referred to the United States (US) House of Representatives Committee on Indian Affairs and ordered to be printed January 28, 1868, states the position of the Legislative Assembly of Dakota Territory regarding several matters involving relations and bureaucratic arrangement between the US government and local tribes and Dakota Territory and those tribes, and argues for Dakota Territory playing a greater role in the management of the tribal affairs and the administration of US obligations, including procurement and transportation of Indian goods. Among changes argued for in the document are that the parts of the territory west of Nebraska and south of Montana be organized into a new territory, being almost wholly unconnected and having no interests in common with the other settled portion of the Territory, and that, If the system of small reservations is to be abandoned, and the Indians consolidated and given a territory in Dakota for their exclusive use and benefit, that territory should be located north of the forty-fifth parallel of north latitude. This section of country is capable of containing and supporting all the Indians in Dakota. The document also cites the abundance of timber, gold and other valuable resources south of the 45th parallel as grounds for protesting a proposed plan to include the Black Hills in the Indian territory to be created for the exclusive benefit and habitation of the Indians that portion of Dakota known as the Black Hills.https://commons.und.edu/indigenous-gov-docs/1014/thumbnail.jp

Overcoming the Challenges Associated with Image-based Mapping of Small Bodies in Preparation for the OSIRIS-REx Mission to (101955) Bennu

The OSIRIS-REx Asteroid Sample Return Mission is the third mission in NASA's New Frontiers Program and is the first U.S. mission to return samples from an asteroid to Earth. The most important decision ahead of the OSIRIS-REx team is the selection of a prime sample-site on the surface of asteroid (101955) Bennu. Mission success hinges on identifying a site that is safe and has regolith that can readily be ingested by the spacecraft's sampling mechanism. To inform this mission-critical decision, the surface of Bennu is mapped using the OSIRIS-REx Camera Suite and the images are used to develop several foundational data products. Acquiring the necessary inputs to these data products requires observational strategies that are defined specifically to overcome the challenges associated with mapping a small irregular body. We present these strategies in the context of assessing candidate sample-sites at Bennu according to a framework of decisions regarding the relative safety, sampleability, and scientific value across the asteroid's surface. To create data products that aid these assessments, we describe the best practices developed by the OSIRIS-REx team for image-based mapping of irregular small bodies. We emphasize the importance of using 3D shape models and the ability to work in body-fixed rectangular coordinates when dealing with planetary surfaces that cannot be uniquely addressed by body-fixed latitude and longitude.Comment: 31 pages, 10 figures, 2 table

A phylogeny-aware GWAS framework to correct for heritable pathogen effects on infectious disease traits.

Infectious diseases are particularly challenging for genome-wide association studies (GWAS) because genetic effects from two organisms (pathogen and host) can influence a trait. Traditional GWAS assume individual samples are independent observations. However, pathogen effects on a trait can be heritable from donor to recipient in transmission chains. Thus, residuals in GWAS association tests for host genetic effects may not be independent due to shared pathogen ancestry. We propose a new method to estimate and remove heritable pathogen effects on a trait based on the pathogen phylogeny prior to host GWAS, thus restoring independence of samples. In simulations, we show this additional step can increase GWAS power to detect truly associated host variants when pathogen effects are highly heritable, with strong phylogenetic correlations. We applied our framework to data from two different host-pathogen systems, HIV in humans and X. arboricola in A. thaliana. In both systems, the heritability and thus phylogenetic correlations turn out to be low enough such that qualitative results of GWAS do not change when accounting for the pathogen shared ancestry through a correction step. This means that previous GWAS results applied to these two systems should not be biased due to shared pathogen ancestry. In summary, our framework provides additional information on the evolutionary dynamics of traits in pathogen populations and may improve GWAS if pathogen effects are highly phylogenetically correlated amongst individuals in a cohort