Cystatin C, a marker for successful aging and glomerular filtration rate, is not influenced by inflammation

Abstract Background. The plasma level of cystatin C is a better marker than plasma creatinine for successful aging. It has been assumed that the advantage of cystatin C is not only due to it being a better marker for glomerular filtration rate (GFR) than creatinine, but also because an inflammatory state of a patient induces a raised cystatin C level. However, the observations of an association between cystatin C level and inflammation stem from large cohort studies. The present work concerns the cystatin C levels and degree of inflammation in longitudinal studies of individual subjects without inflammation, who undergo elective surgery. Methods. Cystatin C, creatinine, and the inflammatory markers CRP, serum amyloid A (SAA), haptoglobin and orosomucoid were measured in plasma samples from 35 patients the day before elective surgery and subsequently during seven consecutive days. Results. Twenty patients had CRP-levels below 1 mg/L before surgery and low levels of the additional inflammatory markers. Surgery caused marked inflammation with high peak values of CRP and SAA on the second day after the operation. The cystatin C level did not change significantly during the observation period and did not correlate significantly with the level of any of the four inflammatory markers. The creatinine level was significantly reduced on the first postoperative day but reached the preoperative level towards the end of the observation period. Conclusion. The inflammatory status of a patient does not influence the role of cystatin C as a marker of successful aging, nor of GFR

Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey

Background: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods: This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure. Results: Nine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout. There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management. Conclusions: There was a significant burnout among trainees. Almost all aspects of clinical and research activities were affected with a significant reduction in the volume of research, outpatient clinic visits, surgical procedures, on-call hours, and emergency cases hindering the training. Trial registration: The study was registered on clicaltrials.gov "NCT04433286" on 16/06/2020

Case study: legal requirements for the use of social login features for online reputation updates

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Study of the influence of annealing on the properties of CBS-CdS thin films

International audienc

Recent studies on In2S3 containing oxygen thin films

International audienc

Horizontal and Vertical Geotechnical Variations of Soils According to USCS Classification for the City of An-Najaf, Iraq Using GIS

The unified soil classification system (USCS) first proposed by Casagrande and subsequently developed by the Army Corps of Engineers. It widely used in many building codes and books. An-Najaf city is the most important city in Iraq due to its religious and spiritual value in the Muslim world, so it is fast expanding and continuous developing city in Iraq. The data from 464 boreholes in the study area for depths of 0–26 m have been used. 13 Soil samples were collected from each borehole with 13 depths level (0–26) m with 2 m intervals. The USCS was applied to the soil samples from 13 depth levels borehole. This research aims to create a geodatabase for soil properties for An-Najaf. The ArcGIS 10.5 software was used to interpolate the spatial data to produce 33 geotechnical maps for fine soil, coarse soil and USCS for 13 depth levels. For numerical soil data, Ordinary Kriging has been used for interpolation mapping of Fine and Coarse percentage data for each depth. For non-numerical (nominal) soil data (USCS class), the Indicator Kriging method is used. The results show that the coarse soil occupied 85–95% for depth 0–16 m and consist of (SP, SP-SM, SM) while fine soil occupied 5–15% consisting of (OL, CH, ML) subsequently, this soil when compacted has a permeability of pervious to semi impervious, good shearing strength, low to very low compressibility and acceptable workability as a construction material. The results also show that after 16 m depths until 26 m, the fine soil percentage increased to 40% with a coarse soil percentage of 60%, indicating changes in soil characteristics as the permeability became semi-pervious to impervious, fair shearing strength, medium compressibility and fair workability as a construction material. The study results will provide help and saving time, efforts and money in preliminary engineering designs.Validerad;2020;Nivå 2;2020-03-13 (johcin)</p