Evaluasi Kinerja Pegawai di Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu Kabupaten Minahasa

This research is aimed at identifying, describing and analyzing the performance evaluation of officers in the Capital Plantation and Integrated Services Department of One Door Minahasa Cabinet. This research uses qualitative descriptive methods. Data is collected through observation techniques, interviews and interviews, documentation. The results of this study, showing the quality of the work of the staff in the license area, is still less related to the standards of work applied by the office not fully implemented by the existing staff, such as operating computers or mastering IT. The still poor work culture also greatly affects the performance of the existing staff. And there are barriers that affect the quality of the performance of officials, that is, the limitation of resources and supplies that are still lacking and the minimum budget of the licensing field

FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN HIPERTENSI PADA GURU SEKOLAH DASAR DI KECAMATAN TOMBARIRI TIMUR

Hipertensi atau tekanan darah tinggi merupakan salah satu masalah kesehatan masyarakat yang menjadi penyebab penting kematian dini di seluruh dunia. Hampir satu miliar orang di dunia terkena hipertensi dan dua dari tiga kasus terjadi di negara berkembang. Hampir satu miliar orang di dunia terkena hipertensi dan dua dari tiga kasus terjadi di negara berkembang. Hipertensi merupakan faktor risiko utama kematian 1,5 juta jiwa setiap tahun di wilayah asia tenggara dan timur. Tujuan penelitian ini yaitu untuk mengetahui faktor-faktor yang berhubungan dengan kejadian hipertensi pada guru di Sekolah Dasar yang ada di Kecamatan Tombariri Timur. Metode penelitian menggunakan pendekatan cross sectional dengan jumlah populasi sebanyak 80 responden. Instrument penelitian ini menggunakan kuesioner GPAQ, PSS dan HARS. Analisis dalam penelitian ini menggunakan uji t-test ditemukan hubungan antara umur dengan kejadian hipertensi (p=0,000) dan uji chi-square ditemukan hubungan antara riwayat keluarga (p=0,000) dan kecemasan (p=0,000) dan tidak ditemukan hubungan antara jenis kelamin (p=1,000), Aktivitas fisik (p=0.141) dan Stres (p=0.866). Kata Kunci: Hipertensi, Umur, Jenis Kelamin, Riwayat Keluarga, Aktivitas Fisik, Stres, Kecemasan ABSRACTHypertension or high blood pressure is one of the public health problems that is an important cause of premature death worldwide. Nearly one billion people worldwide suffer from hypertension and two out of three cases occur in developing countries. Nearly one billion people worldwide suffer from hypertension and two out of three cases occur in developing countries. Hypertension is a major risk factor for death of 1.5 million people each year in the Southeast and East Asia region. The purpose of this study was to determine the factors associated with the incidence of hypertension in teachers in elementary schools in East Tombariri District. The research method uses a cross sectional approach with a population of 80 respondents. The research instrument used the GPAQ, PSS and HARS questionnaires. The analysis in this study using the t-test found a relationship between age and the incidence of hypertension (p = 0,000) and the chi-square test found an association between family history (p = 0,000) and anxiety (p = 0,000) and no relationship was found between sexes (p = 1,000), physical activity (p = 0.141) and stress (p = 0.866). Keywords: Hypertension, Age, Gender, Family History, Physical Activity, Stress, Anxiet

PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE EXAMPLES NON EXAMPLES UNTUK MENINGKATKAN AKTIVITAS DAN KEMAMPUAN BERPIKIR KRITIS PESERTA DIDIK SMP NEGERI 3 BATANGHARI

This study aims to determine the increase in learning activities and students' critical thinking abilities in circle material through the application of cooperative learning types Examples and Non Examples in Eight Grade Students of SMP Negeri 3 Batanghari. The research method is classroom action research which consists of four stages including: planning, implementation, observation, and reflection. The subjects of this study were students of class Eight Grade Students of SMP Negeri 3 Batanghari. Data collection uses instruments in the form of learning activity observation sheets and critical thinking ability test sheets consisting of 5 questions. The results of the study indicate the existence of: 1) Increased learning activities in the learning process. This can be seen from the increase in each indicator, the average percentage of learning activities per indicator, namely: a) focus of material presentation from teacher in the pre-survey is 78%. It decreases to 69.23% in the first cycle, then increasing to 82% in second cycle. b) Asking questions, in pre-survey at 9%, increased to 46.17% in first cycle, then increased to 62.8% in second cycle. c) Answering questions, in pre-survey by 4%, increasing to 42.33% in first cycle, and then increasing to 61.57% in second cycle. d) The activity in group discussions, in pre-survey by 57%, increasing to 55.1% in the first cycle, and then increasing to 65.37% in cycle II. e) Presenting group assignments, in pre-survey by 22%, increasing to 42.27% in first cycle, and then increasing to 62.8% in second cycle. 2) Increasing the percentage of learning outcomes of students' critical thinking skills from pre-survey by 30.33%, increasing to 30.76% in cycle I, and then increasing to 65.38% in cycle II. The conclusion of this study is that the application of the cooperative learning model type Examples Non Examples can: 1) Increase the learning activities of Eight Grades students of SMP Negeri 3 Batanghari 2018/2019 Academic Year. 2) Learning outcomes that refer to the critical thinking skills of Eight Grade Students of SMP Negeri 3 Batanghari ware improve

Combinations of β-lactam or aminoglycoside antibiotics with plectasin are synergistic against methicillin-sensitive and methicillin-resistant Staphylococcus aureus.

Bacterial infections remain the leading killer worldwide which is worsened by the continuous emergence of antibiotic resistance. In particular, methicillin-sensitive (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) are prevalent and the latter can be difficult to treat. The traditional strategy of novel therapeutic drug development inevitably leads to emergence of resistant strains, rendering the new drugs ineffective. Therefore, rejuvenating the therapeutic potentials of existing antibiotics offers an attractive novel strategy. Plectasin, a defensin antimicrobial peptide, potentiates the activities of other antibiotics such as β-lactams, aminoglycosides and glycopeptides against MSSA and MRSA. We performed in vitro and in vivo investigations to test against genetically diverse clinical isolates of MSSA (n = 101) and MRSA (n = 115). Minimum inhibitory concentrations (MIC) were determined by the broth microdilution method. The effects of combining plectasin with β-lactams, aminoglycosides and glycopeptides were examined using the chequerboard method and time kill curves. A murine neutropenic thigh model and a murine peritoneal infection model were used to test the effect of combination in vivo. Determined by factional inhibitory concentration index (FICI), plectasin in combination with aminoglycosides (gentamicin, neomycin or amikacin) displayed synergistic effects in 76-78% of MSSA and MRSA. A similar synergistic response was observed when plectasin was combined with β-lactams (penicillin, amoxicillin or flucloxacillin) in 87-89% of MSSA and MRSA. Interestingly, no such interaction was observed when plectasin was paired with vancomycin. Time kill analysis also demonstrated significant synergistic activities when plectasin was combined with amoxicillin, gentamicin or neomycin. In the murine models, plectasin at doses as low as 8 mg/kg augmented the activities of amoxicillin and gentamicin in successful treatment of MSSA and MRSA infections. We demonstrated that plectasin strongly rejuvenates the therapeutic potencies of existing antibiotics in vitro and in vivo. This is a novel strategy that can have major clinical implications in our fight against bacterial infections

Analisis Sifat Fisika dan Derajat Keasaman terhadap Kualitas Air Minum Isi Ulang 20 Rumah RW 01 di Kampung Cilember Desa Jogjogan Kecamatan Cisarua Kabupaten Bogor

Air merupakan sumber daya alam yang berperan penting dalam kehidupan setelah udara, salah satu peran terpentingnya adalah untuk dikonsumsi. Namun, permasalahan yang sering terjadi adalah kurangnya pengetahuan masyarakat tentang kualitas air minum khususnya isi ulang yang dikonsumsi. Tujuan dari penelitian ini adalah untuk menganalisis kualitas air minum isi ulang beberapa Rumah di RW 01 Kampung Cilember Desa Jogjogan Kecamatan Cisarua Kabupaten Bogor terhadap hasil uji sifat fisika dan derajat keasamannya. Metode penelitian yang dilakukan dalam pengambilan sampel air minum adalah metode sampel gabungan tempat atau integrated sampel, terdapat 20 rumah warga dilakukan pengambilan sampel air untuk diukur kualitas secara fisika (warna, bau, rasa, TDS dan suhu) dan secara kimia (pH atau derajat keasaman). Berdasarkan hasil pengujian, terdapat 5 rumah yang memenuhi standar kualitas air minum isi ulang dari 20 rumah warga yang diuji. Hal tersebut dapat dilihat dari parameter standar yang berlaku dengan kisaran pH antara 6,5-8,5, TDS rata-rata 600-900 ppm, suhu ±3oC suhu udara, serta tidak memiliki bau, rasa, dan warna

European fitness landscape for children and adolescents: updated reference values, fitness maps and country rankings based on nearly 8 million test results from 34 countries gathered by the FitBack network

OBJECTIVES (1) To develop reference values for health-related fitness in European children and adolescents aged 6-18 years that are the foundation for the web-based, open-access and multilanguage fitness platform (FitBack); (2) to provide comparisons across European countries. METHODS This study builds on a previous large fitness reference study in European youth by (1) widening the age demographic, (2) identifying the most recent and representative country-level data and (3) including national data from existing fitness surveillance and monitoring systems. We used the Assessing Levels of PHysical Activity and fitness at population level (ALPHA) test battery as it comprises tests with the highest test-retest reliability, criterion/construct validity and health-related predictive validity: the 20 m shuttle run (cardiorespiratory fitness); handgrip strength and standing long jump (muscular strength); and body height, body mass, body mass index and waist circumference (anthropometry). Percentile values were obtained using the generalised additive models for location, scale and shape method. RESULTS A total of 7 966 693 test results from 34 countries (106 datasets) were used to develop sex-specific and age-specific percentile values. In addition, country-level rankings based on mean percentiles are provided for each fitness test, as well as an overall fitness ranking. Finally, an interactive fitness platform, including individual and group reporting and European fitness maps, is provided and freely available online (www.fitbackeurope.eu). CONCLUSION This study discusses the major implications of fitness assessment in youth from health, educational and sport perspectives, and how the FitBack reference values and interactive web-based platform contribute to it. Fitness testing can be conducted in school and/or sport settings, and the interpreted results be integrated in the healthcare systems across Europe

European fitness landscape for children and adolescents: updated reference values, fitness maps and country rankings based on nearly 8 million test results from 34 countries gathered by the FitBack network

Objectives (1) To develop reference values for health-related fitness in European children and adolescents aged 6–18 years that are the foundation for the web-based, open-access and multilanguage fitness platform (FitBack); (2) to provide comparisons across European countries. Methods This study builds on a previous large fitness reference study in European youth by (1) widening the age demographic, (2) identifying the most recent and representative country-level data and (3) including national data from existing fitness surveillance and monitoring systems. We used the Assessing Levels of PHysical Activity and fitness at population level (ALPHA) test battery as it comprises tests with the highest test–retest reliability, criterion/construct validity and health-related predictive validity: the 20 m shuttle run (cardiorespiratory fitness); handgrip strength and standing long jump (muscular strength); and body height, body mass, body mass index and waist circumference (anthropometry). Percentile values were obtained using the generalised additive models for location, scale and shape method. Results A total of 7 966 693 test results from 34 countries (106 datasets) were used to develop sex-specific and age-specific percentile values. In addition, country-level rankings based on mean percentiles are provided for each fitness test, as well as an overall fitness ranking. Finally, an interactive fitness platform, including individual and group reporting and European fitness maps, is provided and freely available online (www.fitbackeurope.eu). Conclusion This study discusses the major implications of fitness assessment in youth from health, educational and sport perspectives, and how the FitBack reference values and interactive web-based platform contribute to it. Fitness testing can be conducted in school and/or sport settings, and the interpreted results be integrated in the healthcare systems across Europe